Minus-End-Directed Motor Ncd Exhibits Processive Movement that Is Enhanced by Microtubule Bundling In Vitro

Current Biology

Volumn 18, Issue 2, 2008, Pages 152-157

  Furuta, Ken'ya ^a   Toyoshima, Yoko Yano ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

CELLBIO

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DROSOPHILA PROTEIN; GREEN FLUORESCENT PROTEIN; KINESIN; NCD PROTEIN, DROSOPHILA; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; DROSOPHILA; ELECTRICITY; METABOLISM; MICROTUBULE; PROTEIN QUATERNARY STRUCTURE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; ELECTROSTATICS; GREEN FLUORESCENT PROTEINS; KINESIN; MICROTUBULES; PROTEIN STRUCTURE, QUATERNARY;

EID: 38349076942     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2007.12.056     Document Type: Article

References (32)

1. Endow S.A., Henikoff S., and Soler-Niedziela L. Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. Nature 345 (1990) 81-83
2. McDonald H.B., Stewart R.J., and Goldstein L.S. The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor. Cell 63 (1990) 1159-1165
3. Hatsumi M., and Endow S.A. The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells. J. Cell Sci. 103 (1992) 1013-1020
4. Matthies H.J., McDonald H.B., Goldstein L.S., and Theurkauf W.E. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein. J. Cell Biol. 134 (1996) 455-464
5. Endow S.A., and Komma D.J. Spindle dynamics during meiosis in Drosophila oocytes. J. Cell Biol. 137 (1997) 1321-1336
6. Endow S.A., and Waligora K.W. Determinants of kinesin motor polarity. Science 281 (1998) 1200-1202
7. Foster K.A., Mackey A.T., and Gilbert S.P. A mechanistic model for Ncd directionality. J. Biol. Chem. 276 (2001) 19259-19266
8. Chandra R., Salmon E.D., Erickson H.P., Lockhart A., and Endow S.A. Structural and functional domains of the Drosophila ncd microtubule motor protein. J. Biol. Chem. 268 (1993) 9005-9013
9. Karabay A., and Walker R.A. Identification of microtubule binding sites in the Ncd tail domain. Biochemistry 38 (1999) 1838-1849
10. Goshima G., Nedelec F., and Vale R.D. Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. J. Cell Biol. 171 (2005) 229-240
11. Tao L., Mogilner A., Civelekoglu-Scholey G., Wollman R., Evans J., Stahlberg H., and Scholey J.M. A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays. Curr. Biol. 16 (2006) 2293-2302
12. Oladipo A., Cowan A., and Rodionov V. Microtubule motor Ncd induces sliding of microtubules in vivo. Mol. Biol. Cell 18 (2007) 3601-3606
13. Case R.B., Pierce D.W., Hom-Booher N., Hart C.L., and Vale R.D. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell 90 (1997) 959-966
14. Crevel I.M., Lockhart A., and Cross R.A. Kinetic evidence for low chemical processivity in ncd and Eg5. J. Mol. Biol. 273 (1997) 160-170
15. Stewart R.J., Semerjian J., and Schmidt C.F. Highly processive motility is not a general feature of the kinesins. Eur. Biophys. J. 27 (1998) 353-360
16. deCastro M.J., Ho C.H., and Stewart R.J. Motility of dimeric ncd on a metal-chelating surfactant: evidence that ncd is not processive. Biochemistry 38 (1999) 5076-5081
17. Inoue Y., Iwane A.H., Miyai T., Muto E., and Yanagida T. Motility of single one-headed kinesin molecules along microtubules. Biophys. J. 81 (2001) 2838-2850
18. Okada Y., and Hirokawa N. A processive single-headed motor: Kinesin superfamily protein KIF1A. Science 283 (1999) 1152-1157
19. Svoboda K., Mitra P.P., and Block S.M. Fluctuation analysis of motor protein movement and single enzyme kinetics. Proc. Natl. Acad. Sci. USA 91 (1994) 11782-11786
20. Kwok B.H., Kapitein L.C., Kim J.H., Peterman E.J., Schmidt C.F., and Kapoor T.M. Allosteric inhibition of kinesin-5 modulates its processive directional motility. Nat. Chem. Biol. 2 (2006) 480-485
21. Thorn K.S., Ubersax J.A., and Vale R.D. Engineering the processive run length of the kinesin motor. J. Cell Biol. 151 (2000) 1093-1100
22. Skiniotis G., Cochran J.C., Muller J., Mandelkow E., Gilbert S.P., and Hoenger A. Modulation of kinesin binding by the C-termini of tubulin. EMBO J. 23 (2004) 989-999
23. Lakamper S., and Meyhofer E. The E-hook of tubulin interacts with kinesin's head to increase processivity and speed. Biophys. J. 89 (2005) 3223-3234
24. Ito M., Morii H., Shimizu T., and Tanokura M. Coiled coil in the stalk region of ncd motor protein is nonlocally sustained. Biochemistry 45 (2006) 3315-3324
25. Makino T., Morii H., Shimizu T., Arisaka F., Kato Y., Nagata K., and Tanokura M. Reversible and irreversible coiled coils in the stalk domain of ncd motor protein. Biochemistry 46 (2007) 9523-9532
26. Pechatnikova E., and Taylor E.W. Kinetic mechanism of monomeric non-claret disjunctional protein (Ncd) ATPase. J. Biol. Chem. 272 (1997) 30735-30740
27. Pechatnikova E., and Taylor E.W. Kinetics processivity and the direction of motion of Ncd. Biophys. J. 77 (1999) 1003-1016
28. Nedelec F.J., Surrey T., Maggs A.C., and Leibler S. Self-organization of microtubules and motors. Nature 389 (1997) 305-308
29. Surrey T., Nedelec F., Leibler S., and Karsenti E. Physical properties determining self-organization of motors and microtubules. Science 292 (2001) 1167-1171
30. deCastro M.J., Fondecave R.M., Clarke L.A., Schmidt C.F., and Stewart R.J. Working strokes by single molecules of the kinesin-related microtubule motor ncd. Nat. Cell Biol. 2 (2000) 724-729
31. Badoual M., Julicher F., and Prost J. Bidirectional cooperative motion of molecular motors. Proc. Natl. Acad. Sci. USA 99 (2002) 6696-6701
32. Sciambi C.J., Komma D.J., Skold H.N., Hirose K., and Endow S.A. A bidirectional kinesin motor in live Drosophila embryos. Traffic 6 (2005) 1036-1046