Synthesis and evaluation of a focused library of pyridine dicarbonitriles against prion disease

European Journal of Medicinal Chemistry

Volumn 43, Issue 1, 2008, Pages 93-106

  Guo, Kai ^a   Mutter, Roger ^a   Heal, William ^a   Reddy, Tummala R K ^a   Cope, Hannah ^a   Pratt, Steven ^a   Thompson, Mark J ^a   Chen, Beining ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Microwave irradiation; Prion protein; Pyridine dicarbonitriles; SPR; TSE; vCJD

Indexed keywords

CYANIDE; ISOENZYME; PRION PROTEIN; PROTEINASE; PYRIDINE DERIVATIVE; PYRIDINE DICARBONITRILE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DRUG BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; MICROWAVE IRRADIATION; MOUSE; NONHUMAN; PRION DISEASE; SURFACE PLASMON RESONANCE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; MICE; NITRILES; PRION DISEASES; PRIONS; PYRIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 38349054600     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.02.018     Document Type: Article

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