Screening a library of potential prion therapeutics against cellular prion proteins and insights into their mode of biological activities by surface plasmon resonance

Journal of Pharmaceutical and Biomedical Analysis

Volumn 40, Issue 4, 2006, Pages 822-832

  Touil, Faiza ^a   Pratt, Steven ^a   Mutter, Roger ^a   Chen, Beining ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Carboxymethylated dextran; CJD; Conformational change; Immobilization; Library screening; Prion protein; SPR; TSE

Indexed keywords

1,N6 ETHENOADENOSINE 5C MONOPHOSPHATE DISODIUM; 2 AMINO 6 [(2 AMINOPHENYL)THIO] 4 (2 FURYL)PYRIDINE 3,5 DICARBONITRILE; 2 AMINO 6 [(4 CHLOROPHENYL)THIO] 4 (2 FURYL)PYRIDINE 3,5 DICARBONITRILE; 2 AMINO 6 [(4 CHLOROPHENYL)THIO] 4 (2 THIENYL)PYRIDINE 3,5 DICARBONITRILE; 2 AMINO 6 [(4 CHLOROPHENYL)THIO] 4 PHENYLPYRIDINE 3,5 DICARBONITRILE; 2',3' DI O ACETYLADENOSINE; ADENOSINE 2',3' CYCLIC MONOPHOSPHATE SODIUM; ADENYLYL(3',5')CYTIDINE; BUTIROSIN; CARBAMAZEPINE; CHLORPROMAZINE; CLOZAPINE; COPPER PHTHALOCYANINE TETRASULFONIC ACID TETRASODIUM; HALOPERIDOL; HEPARIN; IMIPRAMINE; LIGAND; MEPACRINE; NITRILE; NUCLEIC ACID; PRION PROTEIN; PROMAZINE; PROMETHAZINE; RIBOSTAMYCIN; SISOMICIN; STREPTOMYCIN SULFATE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UROCANIC ACID; VALPROIC ACID;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONFORMATIONAL TRANSITION; DRUG IDENTIFICATION; DRUG SCREENING; HUMAN; IMMOBILIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SENSOR; SURFACE PLASMON RESONANCE;

BIOSENSING TECHNIQUES; CENTRAL NERVOUS SYSTEM AGENTS; CONGO RED; DRUG DESIGN; KINETICS; LIGANDS; PHENOTHIAZINES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PRPC PROTEINS; PRPSC PROTEINS; QUINACRINE; SURFACE PLASMON RESONANCE;

EID: 32944472715     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.08.011     Document Type: Article

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