메뉴 건너뛰기




Volumn 86, Issue 5, 2007, Pages 422-428

Prognostic significance of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia in an unselected patient population

Author keywords

Acute myeloid leukemia; FLT3 ITD; NPM1 mutation; Prognostic factor; Single institution study

Indexed keywords

CD135 ANTIGEN; NUCLEOPHOSMIN;

EID: 38349053114     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.07116     Document Type: Article
Times cited : (8)

References (24)
  • 1
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
    • Mrózek K, Marcucci G, Paschka P, Whitman SP, Bloomfield CD. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood. 2007;109:431-448.
    • (2007) Blood , vol.109 , pp. 431-448
    • Mrózek, K.1    Marcucci, G.2    Paschka, P.3    Whitman, S.P.4    Bloomfield, C.D.5
  • 2
    • 33744455709 scopus 로고    scopus 로고
    • Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation
    • Kiyoi H, Naoe T. Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation. Int J Hematol. 2006;83:301-308.
    • (2006) Int J Hematol , vol.83 , pp. 301-308
    • Kiyoi, H.1    Naoe, T.2
  • 3
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • for the GIMEMA Acute Leukemia Working Party
    • Falini B, Mecucci C, Tiacci E, et al, for the GIMEMA Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352:254-266.
    • (2005) N Engl J Med , vol.352 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 4
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12:1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3
  • 5
    • 23744444913 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis
    • Yanada M, Matsuo K, Suzuki T, Kiyoi H, Naoe T. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. Leukemia. 2005;19:1345-1349.
    • (2005) Leukemia , vol.19 , pp. 1345-1349
    • Yanada, M.1    Matsuo, K.2    Suzuki, T.3    Kiyoi, H.4    Naoe, T.5
  • 6
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 7
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 8
    • 0024966024 scopus 로고
    • Major nucleolar proteins shuttle between nucleus and cytoplasm
    • Borer RA, Lehner CF, Eppenberger HM, Nigg EA. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell. 1989;56:379-390.
    • (1989) Cell , vol.56 , pp. 379-390
    • Borer, R.A.1    Lehner, C.F.2    Eppenberger, H.M.3    Nigg, E.A.4
  • 9
    • 0024305925 scopus 로고
    • Interaction of nucleolar phosphoprotein B23 with nucleic acids
    • Dumbar TS, Gentry GA, Olson MO. Interaction of nucleolar phosphoprotein B23 with nucleic acids. Biochemistry. 1989;28:9495-9501.
    • (1989) Biochemistry , vol.28 , pp. 9495-9501
    • Dumbar, T.S.1    Gentry, G.A.2    Olson, M.O.3
  • 10
    • 0036052920 scopus 로고    scopus 로고
    • A mammalian in vitro centriole duplication system: Evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication
    • Tarapore P, Okuda M, Fukasawa K. A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication. Cell Cycle. 2002;1:75-81.
    • (2002) Cell Cycle , vol.1 , pp. 75-81
    • Tarapore, P.1    Okuda, M.2    Fukasawa, K.3
  • 11
    • 0025880226 scopus 로고
    • Nucleolin promotes secondary structure in ribosomal RNA
    • Sipos K, Olson MO. Nucleolin promotes secondary structure in ribosomal RNA. Biochem Biophys Res Commun. 1991;177:673-678.
    • (1991) Biochem Biophys Res Commun , vol.177 , pp. 673-678
    • Sipos, K.1    Olson, M.O.2
  • 12
    • 24144494881 scopus 로고    scopus 로고
    • Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
    • Suzuki T, Kiyoi H, Ozeki K, et al. Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. Blood. 2005;106:2854-2861.
    • (2005) Blood , vol.106 , pp. 2854-2861
    • Suzuki, T.1    Kiyoi, H.2    Ozeki, K.3
  • 13
    • 27744502042 scopus 로고    scopus 로고
    • Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype
    • for the Acute Leukemia French Association ALFA
    • Boissel N, Renneville A, Biggio V, et al, for the Acute Leukemia French Association (ALFA). Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype. Blood. 2005;106:3618-3620.
    • (2005) Blood , vol.106 , pp. 3618-3620
    • Boissel, N.1    Renneville, A.2    Biggio, V.3
  • 14
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger S, Schoch C, Kern W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood. 2005;106:3733-3739.
    • (2005) Blood , vol.106 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 15
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • for the AML Study Group AMLSG
    • Döhner K, Schlenk RF, Habdank M, et al, for the AML Study Group (AMLSG). Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005;106:3740-3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Döhner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 16
    • 28444446313 scopus 로고    scopus 로고
    • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    • Verhaak RG, Goudswaard CS, van Putten W, et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood. 2005;106:3747-3754.
    • (2005) Blood , vol.106 , pp. 3747-3754
    • Verhaak, R.G.1    Goudswaard, C.S.2    van Putten, W.3
  • 17
    • 33646557337 scopus 로고    scopus 로고
    • Thiede C, Koch S, Creutzig E, et al, for the Deutsche Studieninitiative Leukämie (DSIL). Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood. 2006;107:4011-4020.
    • Thiede C, Koch S, Creutzig E, et al, for the Deutsche Studieninitiative Leukämie (DSIL). Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood. 2006;107:4011-4020.
  • 18
    • 29144468876 scopus 로고    scopus 로고
    • A randomized, postremission comparison of four courses of standard-dose consolidation therapy without maintenance therapy versus three courses of standard-dose consolidation with maintenance therapy in adults with acute myeloid leukemia: The Japan Adult Leukemia Study Group AML 97 Study
    • and the Japan Adult Leukemia Study Group
    • Miyawaki S, Sakamaki H, Ohtake S, et al, and the Japan Adult Leukemia Study Group. A randomized, postremission comparison of four courses of standard-dose consolidation therapy without maintenance therapy versus three courses of standard-dose consolidation with maintenance therapy in adults with acute myeloid leukemia: the Japan Adult Leukemia Study Group AML 97 Study. Cancer. 2005;104:2726-2734.
    • (2005) Cancer , vol.104 , pp. 2726-2734
    • Miyawaki, S.1    Sakamaki, H.2    Ohtake, S.3
  • 19
    • 34347386848 scopus 로고    scopus 로고
    • A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RARα transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study
    • for the Japan Adult Leukemia Study Group
    • Asou N, Kishimoto Y, Kiyoi H, et al, for the Japan Adult Leukemia Study Group. A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RARα transcript after consolidation therapy: the Japan Adult Leukemia Study Group (JALSG) APL97 study. Blood. 2007;110:59-66.
    • (2007) Blood , vol.110 , pp. 59-66
    • Asou, N.1    Kishimoto, Y.2    Kiyoi, H.3
  • 20
    • 0032188805 scopus 로고    scopus 로고
    • on behalf of the Medical Research Council Adult and Children's Leukaemia Working Parties. The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial
    • Grimwade D, Walker H, Oliver F, et al, on behalf of the Medical Research Council Adult and Children's Leukaemia Working Parties. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood. 1998;92:2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 21
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H, Naoe T, Nakano Y, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074-3080.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3
  • 22
    • 27744451026 scopus 로고    scopus 로고
    • No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): An analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials
    • Gale RE, Hills R, Kottaridis PD, et al. No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials. Blood. 2005;106:3658-3665.
    • (2005) Blood , vol.106 , pp. 3658-3665
    • Gale, R.E.1    Hills, R.2    Kottaridis, P.D.3
  • 23
    • 33847417644 scopus 로고    scopus 로고
    • Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML
    • and the AML SHG 96 Study Group
    • Bornhäuser M, Illmer T, Schaich M, Soucek S, Ehninger G, Thiede C, and the AML SHG 96 Study Group. Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML. Blood. 2007;109:2264-2265.
    • (2007) Blood , vol.109 , pp. 2264-2265
    • Bornhäuser, M.1    Illmer, T.2    Schaich, M.3    Soucek, S.4    Ehninger, G.5    Thiede, C.6
  • 24
    • 33645501151 scopus 로고    scopus 로고
    • Nucleophosmin mutations in de novo acute myeloid leukemia: The age-dependent incidences and the stability during disease evolution
    • Chou WC, Tang JL, Lin LI, et al. Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution. Cancer Res. 2006;66:3310-3316.
    • (2006) Cancer Res , vol.66 , pp. 3310-3316
    • Chou, W.C.1    Tang, J.L.2    Lin, L.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.