Characterization of a subset of antigen-specific human central memory CD4+ T lymphocytes producing effector cytokines

European Journal of Immunology

Volumn 38, Issue 1, 2008, Pages 273-282

  Stubbe, Muriel ^a   Vanderheyde, Nathalie ^a   Pircher, Hanspeter ^b   Goldman, Michel ^a   Marchant, Arnaud ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Helper T cells; Memory cells; Vaccination

Indexed keywords

ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; KILLER CELL LECTIN LIKE RECEPTOR G1; LECTIN RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOSTIMULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROLOGY; STAINING; VACCINATION;

ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL DIFFERENTIATION; CYTOKINES; CYTOMEGALOVIRUS; FLOW CYTOMETRY; HEPATITIS B VIRUS; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; PHENOTYPE; RECEPTORS, CCR7; RECEPTORS, KIR; T-LYMPHOCYTE SUBSETS; TETANUS TOXOID;

EID: 38349051324     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737611     Document Type: Article

References (43)

1. Ahmed, R. and Gray, D., Immunological memory and protective immunity: Understanding their relation. Science 1996. 272: 54-60.
2. Zinkernagel, R. M., On natural and artificial vaccinations. Annu. Rev. Immunol. 2003. 21: 515-546.
3. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
4. Bouneaud, C., Garcia, Z., Kourilsky, P. and Pannetier, C., Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo. J. Exp. Med. 2005. 201: 579-590.
5. Wherry, E. J., Teichgraber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H. and Ahmed, R., Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 2003. 4: 225-234.
6. Zaph, C., Uzonna, J., Beverley, S.M. and Scott, P., Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites. Nat. Med. 2004. 10: 1104-1110.
7. Wu, C. Y., Kirman, J. R., Rotte, M. J., Davey, D. F., Perfetto, S. P., Rhee, E. G., Freidag, B. L. et al., Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo. Nat. Immunol. 2002. 3: 852-858.
8. + central memory T cells and survival in vaccinated SIV-challenged monkeys. Science 2006. 312: 1530-1533.
9. + central memory T cells. J. Exp. Med. 2007. 204: 79-91.
10. Zanetti, M. and Franchini, G., T cell memory and protective immunity by vaccination: Is more better? Trends Immunol. 2006. 27: 511-517.
11. + central memory T cells. J. Exp. Med. 2004. 200: 725-735.
12. Debes, G. F., Hopken, U. E. and Hamann, A., In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7. J. Immunol. 2002. 168: 5441-5447.
13. + T cells depends on antigen specificity and tissue localization during influenza A virus infection. J. Virol. 2004. 78: 7528-7535.
14. - memory T cells do not differ in immediate effector cell function. J Immunol. 2002. 169: 638-641.
15. + T lymphocytes produce multiple cytokines and proliferate in vivo in humans. J. Immunol. 2006. 177: 8185-8190.
16. Intlekofer, A. M., John, W. E. and Reiner, S. L., Not-so-great expectations: Re-assessing the essence of T-cell memory. Immunol. Rev. 2006. 211: 203-213.
17. + T cell response to Epstein-Barr virus during primary and persistent infection. J. Exp. Med. 2003. 198: 903-911.
18. + T cells are predominantly distributed among six phenotypically and functionally distinct subsets. J. Immunol. 2005. 175: 5765-5773.
19. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002. 8: 379-385.
20. Kondrack, R. M., Harbertson, J., Tan, J. T., McBreen, M. E., Surh, C. D. and Bradley, L. M., Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 2003. 198: 1797-1806.
21. +T cell memory. Proc. Natl. Acad. Sci. USA 2004. 101: 9357-9362.
22. Li, J., Huston, G. and Swain, S. L., IL-7 promotes the transition of CD4 effectors to persistent memory cells. J. Exp. Med. 2003. 198: 1807-1815.
23. Seddon, B., Tomlinson, P. and Zamoyska, R., Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 2003.4: 680-686.
24. Cellerai, C., Harari, A., Vallelian, F., Boyman, O. and Pantaleo, G., Functional and phenotypic characterization of tetanus toxoid-specific human CD4(+) T cells following re-immunization. Eur. J. Immunol. 2007. 37: 1129-1138.
25. + T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J. Virol. 2007. 81: 945-953.
26. Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D. and Ahmed, R., Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 2003. 4: 1191-1198.
27. + T lymphocytes during active, latent, and resolved infection and its relation with CD57. J. Immunol. 2005. 174: 6088-6094.
28. Thimme, R., Appay, V., Koschella, M., Panther, E., Roth, E., Hislop, A. D., Rickinson, A. B. et al., Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J. Virol. 2005. 79: 12112-12116.
29. + T cells with diverse cytokine profiles. Nat. Med. 2005. 11: 1113-1117.
30. + T cells specific for defined antigens according to CD154 expression. Nat. Med. 2005. 11: 1118-1124.
31. + T lymphocytes with cellular maturation. J. Exp. Med. 2006. 203: 2865-2877.
32. Fritsch, R. D., Shen, X., Sims, G. P., Hathcock, K. S., Hodes, R. J. and Lipsky, P. E., Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J. Immunol. 2005. 175: 6489-6497.
33. + T cells in blood determines proliferative response. J. Clin. Invest. 2005. 115: 2886-2893.
34. Kim, C. H., Rott, L., Kunkel, E. J., Genovese, M. C., Andrew, D. P., Wu, L. and Butcher, E. C., Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Invest. 2001. 108: 1331-1339.
35. Bingaman, A. W., Patke, D. S., Mane, V. R., Alunadzadeh, M., Ndejembi, M., Bartlett, S. T. and Farber, D. L., Novel phenotypes and migratory properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue. Eur. J. Immunol. 2005. 35: 3173-3186.
36. Surh, C. D., Boyman, O., Purton, J. F. and Sprent, J., Homeostasis of memory T cells. Immunol. Rev. 2006. 211: 154-163.
37. Divekar, A. A., Zaiss, D. M., Lee, F. E., Liu, D., Topham, D. J., Sijts, A. J. and Mosmann, T. R., Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells. J. Immunol. 2006. 176: 1465-1473.
38. Voehringer, D., Blaser, C., Brawand, P., Raulet, D. H., Hanke, T. and Pitcher, H., Viral infections induce abundant numbers of senescent CD8 T cells. J. Imnumol. 2001. 167: 4838-4843.
39. Grundemann, C., Bauer, M., Schweier, O., von Oppen, N., Lassing, U., Saudan, P., Becker, K. F. et al., Cutting edge: Identification of E-cadherin as a ligand for the routine killer cell lectin-like receptor G1. J. Immunol. 2006. 176: 1311-1315.
40. Ito, M., Maruyama, T., Saito, N., Koganei, S., Yamamoto, K. and Matsumoto, N., Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J. Exp. Med. 2006. 203: 289-295.
41. Schwartzkopff, S., Gründemann, C., Schweier, O., Rosshart, S., Karjalainen, K. E., Becker, K.-F. and Pircher, H., Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 (KLRG1) in humans. J. Immunol. 2007. 179: 1022-1029.
42. Robbins, S. H., Terrizzi, S. C., Sydora, B. C., Mikayama, T. and Brossay, L., Differential regulation of killer cell lectin-like receptor G1 expression on T cells. J. Immunol. 2003. 170: 5876-5885.
43. Voehringer, D., Koschella, M. and Pitcher, H., Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectin-like receptor G1 (KLRG1). Blood 2002. 100: 3698-3702.