Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor α agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 710-715

  Faucher, Nicolas ^a   Martres, Paul ^a   Laroze, Alain ^a   Pineau, Olivier ^a   Potvain, Florent ^a   Grillot, Didier ^a  

^a GLAXOSMITHKLINE   (France)

Author keywords

Fibrate; Peroxisome proliferator activated receptors; Trifluoromethane sulfonamide

Indexed keywords

APOLIPOPROTEIN A1; BEZAFIBRATE; CIPROFIBRATE; CLOFIBRATE; FENOFIBRATE; GW 590735; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; ROSIGLITAZONE; SULFONAMIDE; TRIFLUOROMETHANE SULFONAMIDE DERIVATIVE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DYSLIPIDEMIA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTRIGLYCERIDEMIA; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM;

ANIMALS; CELL LINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; PPAR ALPHA; SULFONAMIDES;

EID: 38149137301     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.053     Document Type: Article

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