Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity

Journal of Medicinal Chemistry

Volumn 39, Issue 11, 1996, Pages 2232-2244

  Ornstein, Paul L ^a   Arnold, M Brian ^a   Allen, Nancy K ^a   Bleisch, Thomas ^a   Borromeo, Peter S ^a   Lugar, Charles W ^a   Leander, J David ^a   Lodge, David ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; 6 [2 (1 TETRAZOL 5 YL)ETHYL] 1,2,3,4,4A,5,6,7,8,8A DECAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 6 [2 (1H TETRAZOL 5 YL)ETHYL] 1,2,3,4,4A,5,6,7,8,8A DECAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; CARBOXYLIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; DRUG POTENCY; IN VIVO STUDY; LIGAND BINDING; MEMBRANE DEPOLARIZATION; NONHUMAN; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CARBOXYLIC ACIDS; CEREBRAL CORTEX; ELECTROSHOCK; ISOQUINOLINES; KAINIC ACID; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPECOLIC ACIDS; RATS; RECEPTORS, AMPA; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029946631     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950913h     Document Type: Article

References (23)

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