Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders

Arthritis and Rheumatism

Volumn 58, Issue 1, 2008, Pages 172-183

  Yamakawa, Kiyofumi ^a   Kamekura, Satoru ^a   Kawamura, Naohiro ^a   Saegusa, Masatomo ^a   Kamei, Daisuke ^b   Murakami, Makoto ^c   Kudo, Ichiro ^b   Uematsu, Satoshi ^d   Akira, Shizuo ^d   Chung, Ung Il ^a   Nakamura, Kozo ^a   Kawaguchi, Hiroshi ^a,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b SHOWA UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSOME ENZYME; PROSTAGLANDIN E SYNTHASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DISEASE; BONE METABOLISM; BONE REMODELING; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; FRACTURE NONUNION; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; OSTEOLYSIS; PHENOTYPE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RIB CARTILAGE;

ANIMALS; BONE DISEASES, METABOLIC; CHONDROCYTES; DISEASE MODELS, ANIMAL; FRACTURE HEALING; FRACTURES, BONE; INTRAMOLECULAR OXIDOREDUCTASES; JOINT INSTABILITY; MICE; MICE, MUTANT STRAINS; MICROSOMES; OSTEOARTHRITIS; OVARIECTOMY; PHENOTYPE; PROSTAGLANDINS; WEIGHT-BEARING;

EID: 38149133229     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23158     Document Type: Article

References (46)

1. Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG. The role of prostaglandins in the regulation of bone metabolism. Clin Orthop Relat Res 1995;313:36-46.
2. Kobayashi T, Narumiya S. Function of prostanoid receptors: studies on knockout mice. Prostaglandins Other Lipid Mediat 2002;68-69:557-73.
3. 2-biosynthetic pathway. Prog Lipid Res 2004;43:3-35.
4. 2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem 2000;275: 32783-92.
5. Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A 1999;96:7220-5.
6. Kamei D, Murakami M, Nakatani Y, Ishikawa Y, Ishii T, Kudo I. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J Biol Chem 2003;278:19396-405.
7. Naraba H, Yokoyama C, Tago N, Murakami M, Kudo I, Fueki M, et al. Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene: essential role of the transcription factor Egr-1. J Biol Chem 2002;277:28601-8.
8. Tanikawa N, Ohmiya Y, Ohkubo H, Hashimoto K, Kanagawa K, Kojima M, et al. Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem Biophys Res Commun 2002;291:884-9.
9. 2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J Biol Chem 2003;278:37937-47.
10. 2 synthase to bone resorption. J Cell Physiol 2003;197: 348-56.
11. 2 biosynthesis. J Biol Chem 2000;275:32775-82.
12. 2 synthase by 90-kDa heat shock protein. Biochem Biophys Res Commun 2003;303:1018-23.
13. 2 synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol 2002; 168:5811-6.
14. Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A 2003;100:9044-9.
15. Kamei D, Yamakawa K, Takegoshi Y, Mikami-Nakanishi M, Nakatani Y, Oh-ishi S, et al. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1. J Biol Chem 2004;279:33684-95.
16. Okada Y, Lorenzo JA, Freeman AM, Tomita M, Morham SG, Raisz LG, et al. Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture. J Clin Invest 2000;105:823-32.
17. 2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J Immunol 2006;177:1879-85.
18. 2 agonist induces bone healing. Proc Natl Acad Sci U S A 2003;100: 6736-40.
19. Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair [published erratum appears in J Clin Invest 2002;110:1211]. J Clin Invest 2002;109:1405-15.
20. Simon AM, Manigrasso MB, O'Connor JP. Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 2002;17:963-76.
21. Goldring MB, Berenbaum F. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin Orthop Relat Res 2004:S37-46.
22. Laufer S. Role of eicosanoids in structural degradation in osteoarthritis. Curr Opin Rheumatol 2003;15:623-7.
23. 2 modulates cartilage proteoglycan degradation in human osteoarthritis expiants. Arthritis Rheum 2002;46:1789-803.
24. 2 through cAMP-dependent pathway. Osteoarthritis Cartilage 2000;8:17-24.
25. 2 receptors in the pathogenesis of rheumatoid arthritis. J Clin Invest 2002;110:651-8.
26. Jacques C, Sautet A, Moldovan M, Thomas B, Humbert L, Berenbaum F. Cyclooxygenase activity in chondrocytes from osteoarthritic and healthy cartilage. Rev Rhum Engl Ed 1999;66: 701-4.
27. Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S. Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res Ther 2004;6:R355-65.
28. Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, et al. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004;113:846-55.
29. Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 2005;13:632-41.
30. Yamada T, Kawano H, Koshizuka Y, Fukuda T, Yoshimura K, Kamekura S, et al. Carminerin contributes to chondrocyte calcification during endochondral ossification. Nat Med 2006;12:665-70.
31. Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006;54:2462-70.
32. Shimoaka T, Kamekura S, Chikuda H, Hoshi K, Chung UI, Akune T, et al. Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem 2004;279:15314-22.
33. Van Griensven M, Lobenhoffer P, Barke A, Tschernig T, Lindenmaier W, Krettek C, et al. Adenoviral gene transfer in a rat fracture model. Lab Anim 2002;36:455-61.
34. Barnes GL, Kostenuik PJ, Gerstenfeld LC, Einhorn TA. Growth factor regulation of fracture repair. J Bone Miner Res 1999;14: 1805-15.
35. Xu M, Choudhary S, Goltzman D, Ledgard F, Adams D, Gronowicz G, et al. Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism? Endocrinology 2005;146:1843-53.
36. Myers LK, Bhattacharya SD, Herring PA, Xing Z, Goorha S, Smith RA, et al. The isozyme-specific effects of cyclooxygenase-deficiency on bone in mice. Bone 2006;39:1048-52.
37. Kosaki N, Takaishi H, Kamekura S, Kimura T, Okada Y, Minqi L, et al. Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun 2007;354: 846-51.
38. 2 receptors in growth plate chondrocytes in vitro and in situ: prostaglandin E2 dependent proliferation of growth plate chondrocytes. Arthritis Res Ther 2006;8:R78.
39. Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, et al. Bone morphogenetic protein 2 induces cyclooxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. J Bone Miner Res 2002;17:1430-40.
40. Masuko-Hongo K, Berenbaum F, Humbert L, Salvat C, Goldring MB, Thirion S. Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum 2004;50: 2829-38.
41. Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis: the influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br 2000;82:655-8.
42. Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Cullinane DM, Krall EA, Fitch JL, et al. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing: reversibility of effects after short-term treatment. J Bone Joint Surg Am 2007;89: 114-25.
43. Dieppe PA, Ebrahim S, Martin RM, Juni P. Lessons from the withdrawal of rofecoxib. BMJ 2004;329:867-8.
44. Cheng Y, Wang M, Yu Y, Lawson J, Funk CD, Fitzgerald GA. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest 2006;116:1391-9.
45. Langenbach R, Loftin C, Lee C, Tiano H. Cyclooxygenase knockout mice: models for elucidating isoform-specific functions. Biochem Pharmacol 1999;58:1237-46.
46. 2 synthase (mPGES-1) derived from MK-886. Bioorg Med Chem Lett 2005;15:3352-5.