Phenotypic analysis of Dlx5 overexpression in post-natal bone

Journal of Dental Research

Volumn 87, Issue 1, 2008, Pages 45-50

  Zhang, J ^a,b   Zhu, J ^a   Valverde, P ^a   Li, L ^a   Pageau, S ^a   Tu, Q ^a   Nishimura, R ^c   Yoneda, T ^c   Yang, P ^b   Zheng, W ^d   Ma, W ^e   Chen, J ^a  

^a TUFTS UNIVERSITY SCHOOL OF DENTAL MEDICINE   (United States)

^b SHANDONG UNIVERSITY   (China)

^c OSAKA UNIVERSITY   (Japan)

^d Southern China Genomics Research Center   (China)

^e SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

BSP TVA transgenic mice; Dlx5 (distal less related gene); Extracellular matrix proteins; Homeodomain; Mineralization

Indexed keywords

ARGININE; AVIAN PROTEIN; BONE SIALOPROTEIN; DLX5 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; OSTEOCALCIN; OSTEOPONTIN; SCLEROPROTEIN; SIALOGLYCOPROTEIN; TVA RECEPTOR; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

ANIMAL; ARTICLE; BONE; BONE DEVELOPMENT; BONE MINERALIZATION; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; METABOLISM; MOUSE; MUTATION; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; ARGININE; AVIAN PROTEINS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; GENETIC VECTORS; HOMEODOMAIN PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; OSTEOCALCIN; OSTEOGENESIS; OSTEOPONTIN; PHENOTYPE; RECEPTORS, VIRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIALOGLYCOPROTEINS;

EID: 38149114220     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910808700107     Document Type: Article

References (32)

1. Abe T, Nomura S, Nakagawa R, Fuj imoto M, Kawase I, Naka T (2006). Osteoblast differentiation is impaired in SOCS-1-deficient mice. J Bone Miner Metab 24:283-290.
2. Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, et al. (1999). Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development 126:3795-3809.
3. Chen J, Zhang Q, McCulloch CA, Sodek J (1991). Immunohistochemical localization of bone sialoprotein in foetal porcine bone tissues: comparisons with secreted phosphoprotein 1 (SPP-I, osteopontin) and SPARC (osteonectin). Histochem J 23:281-289.
4. Chen J, Shapiro HS, Sodek J (1992). Development expression of bone sialoprotein mRNA in rat mineralized connective tissues. J Bone Miner Res 7:987-997.
5. D'Elia AV, Tell G, Paron I, Pellizzari L, Lonigro R, Damante G (2001). Missense mutations of human homeoboxes: a review. Hum Mutat 18:361-374.
6. Depew MJ, Lufkin T, Rubenstein JL (2002). Specification of jaw subdivisions by Dlx genes. Science 298:381-385.
7. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, et al. (1996). Increased bone formation in osteocalcin-deficient mice. Nature 382:448-452.
8. Ecarot-Charrier B, Bouchard F, Delloye C (1989). Bone sialoprotein II synthesized by cultured osteoblasts contains tyrosine sulfate. J Biol Chem 264:20049-20053.
9. Federspiel MJ, Hughes SH (1997). Retroviral gene delivery. Methods Cell Biol 52:179-214.
10. Ferrari D, Kosher RA (2002). Dlx5 is a positive regulator of chondrocyte differentiation during endochondral ossification. Dev Biol 252:257-270.
11. Fisher LW, McBride OW, Termine JD, Young MF (1990). Human bone sialoprotein. Deduced protein sequence and chromosomal localization. J Biol Chem 265:2347-2351.
12. Ganss B, Kim RH, Sodek J (1999). Bone sialoprotein. Crit Rev Oral Biol Med 10:79-98.
13. Gehring WJ, Affolter M, Burglin T (1994). Homeodomain proteins. Annu RevBiochem 63:487-526.
14. Holland EC, Varmus HE (1998). Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc Natl Acad Sci USA 95:1218-1223.
15. Lekic P, Sodek J, McCulloch CA (1996). Osteopontin and bone sialoprotein expression in regenerating rat periodontal ligament and alveolar bone. Anat Rec 244:50-58.
16. Li L, Zhu J, Tu Q, Yamauchi M, Sodek J, Karsenty G, et al. (2005). An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter. J Bone Miner Res 20:1403-1413.
17. Mcintosh I, Dreyer SD, Clough MV, Dunston JA, Eyaid W, Roig CM, et al. (1998). Mutation analysis of LMX1B gene in nail-patella syndrome patients. Am J Hum Genet 63:1651-1658.
18. Meinel L, Fajardo R, Hofmann S, Langer R, Chen J, Snyder B, et al. (2005). Silk implants for the healing of critical size bone defects. Bone 37:688-698.
19. Merlo GR, Zerega B, Paleari L, Trombino S, Mantero S, Levi G (2000). Multiple functions of Dlx genes. Int J Dev Biol 44:619-626.
20. Murshed M, Harmey D, Millan JL, McKee MD, Karsenty G (2005). Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 19:1093-1104.
21. Paz J, Wade K, Kiyoshima T, Sodek J, Tang J, Yamauchi M, et al. (2005). Tissue- and bone cell-specific expression of bone sialoprotein is directed by a 9.0 kb promoter in transgenic mice. Matrix Biol 24:341-352.
22. Ryoo HM, Hoffmann HM, Beumer T, Frenkel B, Towler DA, Stein GS, et al. (1997). Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression, Mol Endocrinol 11:1681-1694.
23. Semina EV, Reiter R, Leysens NJ, Alward WL, Small KW, Datson NA, et al. (1996), Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet 14:392-399.
24. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, et al. (1994). Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci USA 91:2250-2254.
25. Sodek J, Ganss B, McKee MD (2000). Osteopontin, Crit Rev Oral Biol Med 11:279-303.
26. Tadic T, Dodig M, Erceg I, Marijanovic I, Mina M, Kalajzic Z, et al. (2002). Overexpression of Dlx5 in chicken calvarial cells accelerates osteoblastic differentiation. J Bone Miner Res 17:1008-1014.
27. Tu Q, Valverde P, Chen J (2006). Osterix enhances proliferation and osteogenic potential of bone marrow stromal cells. Biochem Biophys Res Commun 341:1257-1265.
28. Valverde P, Tu Q, Chen J (2005). BSP and RANKL induce osteoclastogenesis and bone resorption synergistically. J Bone Miner Res 20:1669-1679.
29. Vastardis H, Karimbux N, Guthua SW, Seidman JG, Seidman CE (1996). A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat Genet 13:417-421.
30. Volk SW, Diefenderfer DL, Christopher SA, Haskins ME, Leboy PS (2005). Effects of osteogenic inducers on cultures of canine mesenchymal stem cells. Am J Vet Res 66:1729-1737.
31. Wang J, Zhou HY, Salih E, Xu L, Wunderlich L, Gu X, et al. (2006). Sitespecific in vivo calcification and osteogenesis stimulated by bone sialoprotein. Calcif Tissue Int 79:179-189.
32. Wilkie AO, Tang Z, Elanko N, Walsh S, Twigg SR, Hurst JA, et al. (2000). Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification. Nat Genet 24:387-390.