LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1α/CXCR4-mediated ERK1/2 and Akt signaling pathways

Journal of Cellular Biochemistry

Volumn 103, Issue 1, 2008, Pages 245-255

  Wu, Minghua ^a,b   Chen, Qiong ^a   Li, Dan ^a   Li, Xiaoling ^a   Li, Xiayu ^a   Huang, Chen ^a   Tang, Yunlian ^a   Zhou, Yanhong ^a   Wang, Di ^a   Tang, Ke ^a   Cao, Li ^a   Shen, Shourong ^b   Li, Guiyuan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Central South University   (China)

Author keywords

Chemotaxis; ERK Akt; Glioblastoma; Invasion; LRRC4; MMP 2; SDF 1 CXCR4

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; ENZYME PRECURSOR; G PROTEIN COUPLED RECEPTOR; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROMATRIX METALLOPROTEINASE 2; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; GLIOBLASTOMA; HUMAN; HUMAN CELL; LRRC4 GENE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

CELL PROLIFERATION; CHEMOKINE CXCL12; CHEMOTAXIS; ENZYME ACTIVATION; ENZYME PRECURSORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GELATINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR4; TUMOR CELLS, CULTURED;

EID: 38149098378     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21400     Document Type: Article

References (34)

1. Bajetto A, Bonavia R, Barbero S, Florio T, Schettini G. 2001. Chemokines and their receptors in the central nervous system. Front Neuroendocrinol 22:147-184.
2. Barbero S, Bajetto A, Bonavia R, Porcile C, Piccioli P, Pirani P, Ravetti JL, Zona G, Spaziante R, Florio T, Schettini G. 2002. Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro. Ann N Y Acad Sci 973:60-69.
3. Barbero S, Bonavia R, Bajetto A, Porcile C, Pirani P, Ravetti JL, Zona GL, Spaziante R, Florio T, Schettini G. 2003. Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res 63:1969-1974.
4. Bonavia R, Bajetto A, Barbero S, Pirani P, Florio T, Schettini G. 2003. Chemokines and their receptors in the CNS: Expression of CXCL12/SDF-1 and CXCR4 and their role in astrocyte proliferation. Toxicol Lett 139:181-189.
5. Chen Y, Stamatoyannopoulos G, Song CZ. 2003. Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res 63:4801-4804.
6. Chintala SK, Tonn JC, Rao JS. 1999. Trix metalloproteinases and their biological function in human gliomas. Int J Dev Neurosci 17:495-502.
7. Ganju RK, Brubaker SA, Meyer J, Dutt P, Yang Y, Qin S, Newman W, Groopman JE. 1998. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem 273:23169-23175.
8. Guleng B, Tateishi K, Ohta M, Kanai F, Jazag A, Ijichi H, Tanaka Y, Washida M, Morikane K, Fukushima Y, Yamori T, Tsuruo T, Kawabe T, Miyagishi M, Taira K, Sata M, Omata M. 2005. Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 65:5864-5871.
9. Hong X, Jiang F, Kalkanis SN, Zhang ZG, Zhang XP, DeCarvalho AC, Katakowski M, Bobbitt K, Mikkelsen T, Chopp M. 2006. SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. Cancer Lett 236:39-45.
10. Jiang Q, Zhou C, Bi Z, Wan Y. 2006. EGF-induced cell migration is mediated by ERK and PI3K/AKT pathways in cultured human lens epithelial cells. J Ocul Pharmacol Ther 22:93-102.
11. Kim MS, Park MJ, Kim SJ, Lee CH, Yoo H, Shin SH, Song ES, Lee SH. 2005. Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. Int J Oncol 27:839-846.
12. Kleihues P, Burger PC, Scheithauer BW. 1993. The new WHO classification of brain tumours. Brain Pathol 3:255-268.
13. Koshiba T, Hosotani R, Wada M, Fujimoto K, Lee JU, Doi R, Arii S, Imamura M. 1997. Detection of matrix metalloproteinase activity in human pancreatic cancer. Surg Today 27:302-304.
14. Kunapuli P, Kasyapa CS, Hawthorn L, Cowell JK. 2004. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway. J Biol Chem 279:23151-23157.
15. Libura J, Drukala J, Majka M, Tomescu O, Navenot JM, Kucia M, Marquez L, Peiper SC, Barr FG, Janowska-Wieczorek A, Ratajczak MZ. 2002. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Blood 100:2597-2606.
16. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. 2001. Malignant glioma: Genetics and biology of a grave matter. Genes 15:1311-1333.
17. Nakada M, Okada Y, Yamashita J. 2003. The role of matrix metalloproteinases in glioma invasion. Front Biosci 8:e261-269.
18. Park BK, Zeng X, Glazer RI. 2001. Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res 61:7647-7653.
19. Porcile C, Bajetto A, Barbieri F, Barbero S, Bonavia R, Biglieri M, Pirani P, Florio T, Schettini G. 2005. Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation. Exp Cell Res 308:241-253.
20. Redjal N, Chan JA, Segal RA, Kung AL. 2006. CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas. Clin Cancer Res 12:6765-6771.
21. Rempel SA, Dudas S, Ge S, Gutierrez JA. 2000. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 6:102-111.
22. Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA. 2003. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci USA 100:13513-13518.
23. Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G. 2006. Human melanoma metastases express functional CX CR4. Clin Cancer Res 12:2427-2433.
24. Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR. 2002. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 62:5930-5938.
25. Taichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS, McCauley LK. 2002. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 62:1832-1837.
26. Wang JR, Qian J, Dong L, Li XL, Tan C, Li J, Zhang BC, Zhou J, Li GY. 2002. Identification of LRRC4, a novel member of leucine-rich repeat (LRR) superfamily, and its expression analysis in brain tumor. Prog Biochem Biophys 29:233-239.
27. Wang L, Zhang ZG, Zhang RL, Gregg SR, Hozeska-Solgot A, LeTourneau Y, Wang Y, Chopp M. 2006. Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci 26:5996-6003.
28. Wehler T, Wolfert F, Schimanski CC, Gockel I, Herr W, Biesterfeld S, Seifert JK, Adwan H, Berger MR, Junginger T, Galle PR, Moehler M. 2006. Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease. Oncol Rep 16:1159-1164.
29. Wu M, Huang C, Gan K, Huang H, Chen Q, Ouyang J, Tang Y, Li X, Yang Y, Zhou H, Zhou Y, Zeng Z, Xiao L, Li D, Tang K, Shen S, Li G. 2006a. LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinaseB/nuclear factor-κB pathway. Mol Biol Cell 17:3534-3542.
30. Wu M, Gan K, Huang C, Tang Y, Chen Q, Tang K, Li X, Shen S, Li G. 2006b. LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression. J Neurooncol 80:133-142.
31. Zhang D, Bar-Eli M, Meloche S, Brodt P. 2004. Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: The phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. J Biol Chem 279:19683-19690.
32. Zhang Q, Wang J, Fan S, Wang L, Cao L, Tang K, Peng C, Li Z, Li W, Gan K, Liu Z, Li X, Shen S, Li G. 2005a. Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. FEBS Lett 579:3674-3682.
33. Zhang J, Sarkar S, Yong VW. 2005b. The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase. Carcinogenesis 26:2069-2077.
34. Zhou Y, Larsen PH, Hao C, Yong VW. 2002. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 277:49481-49487.