Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3- trifluoromethylindole as potential HIV-1 reverse transcriptase inhibitors

Medicinal Chemistry Research

Volumn 15, Issue 9, 2007, Pages 492-510

  Boechat, Núbia ^a   Kover, Warner B ^b   Bastos, Mônica M ^a,b   Romeiro, Nelilma C ^a   Silva, Alessa S C ^a   Santos, Fernanda C ^a   Valverde, Alessandra L ^a   Azevedo, Maria L G ^a   Wollinger, Wagner ^a   Souza, Thiago M L ^b   De Souza, Silmara Lúcia Oliveira ^c   De Frugulhetti, Izabel Christina P P ^c  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL 3 HYDROXY 2 OXO 3 TRIFLUOROMETHYLINDOLE; 1 ACETYL 3 HYDROXY 5 METHYL 2 OXO 3 TRIFLUOROMETHYLINDOLE; 1 ACETYL 5 BROMO 3 HYDROXY 2 OXO 3 TRIFLUOROMETHYLINDOLE; 1 ACETYL 5 CHLORO 3 HYDROXY 2 OXO 3 TRIFLUOROMETHYLINDOLE; 1,5 DIMETHYL 3 HYDROXY 2 OXO 3 TRIFLUOROMETHYLINDOLE; 3 HYDROXY 1 METHYL 2 OXO 3 TRIFLUOROMETHYLINDOLE; 3 HYDROXY 2 OXO 3 TRIFLUOROMETHYLINDOLE; 3 HYDROXY 5 METHYL 2 OXO 3 TRIFLUOROMETHYLINDOLE; 5 BROMO 3 HYDROXY 1 METHYL 2 OXO 3 TRIFLUOROMETHYLINDOLE; 5 BROMO 3 HYDROXY 2 OXO 3 TRIFLUOROMETHYLINDOLE; 5 CHLORO 3 HYDROXY 1 METHYL 2 OXO 3 TRIFLUOROMETHYLINDOLE; 5 CHLORO 3 HYDROXY 2 OXO 3 TRIFLUOROMETHYLINDOLE; EFAVIRENZ; INDOLE DERIVATIVE; ISATIN DERIVATIVE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCULATION; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE;

EID: 38149080648     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-007-9004-0     Document Type: Article

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