New advances in pancreatic cell physiology and pathophysiology

Best Practice and Research in Clinical Gastroenterology

Volumn 22, Issue 1, 2008, Pages 3-15

  Weiss, Frank Ulrich ^a   Halangk, Walter ^b   Lerch, Markus M ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

acinar cell; apoptosis; Ca2+; cathepsin B; chymotrypsin C; exocytosis; necrosis; protease activation; SPINK1; trypsinogen

Indexed keywords

CALCIUM ION; CATHEPSIN B; CHOLECYSTOKININ; CHYMOTRYPSIN; CHYMOTRYPSIN C; ENZYME PRECURSOR; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 2; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR KAZAL TYPE 1; TRYPSIN; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ALCOHOL CONSUMPTION; AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CELL DEATH; CELL FUNCTION; CHRONIC PANCREATITIS; CYTOSKELETON; DISEASE COURSE; ENZYME ACTIVATION; EXOCYTOSIS; GENETIC SUSCEPTIBILITY; HUMAN; NONHUMAN; PANCREAS CELL; PANCREAS FUNCTION; PANCREAS SECRETION; PANCREATITIS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CALCIUM SIGNALING; CARRIER PROTEINS; CELL DEATH; CHOLECYSTOKININ; CHYMOTRYPSIN; ENZYME ACTIVATION; ENZYME PRECURSORS; ETHANOL; EXOCYTOSIS; HUMANS; MUTATION; PANCREAS, EXOCRINE; PANCREATITIS; TRYPSIN;

EID: 38149058901     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpg.2007.10.017     Document Type: Article

References (60)

1. Wang B.J., and Cui Z.J. How does cholecystokinin stimulate exocrine pancreatic secretion? From birds, rodents, to humans. Am J Physiol Regul Integr Comp Physiol 292 2 (2007 Feb) R666-R678
2. Gautam D., Han S.J., Heard T.S., et al. Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice. J Pharmacol Exp Therap 313 3 (2005 Jun) 995-1002
3. Sankaran H., Goldfine I.D., Bailey A., et al. Relationship of cholecystokinin receptor binding to regulation of biological functions in pancreatic acini. Am J Physiol 242 3 (1982 Mar) G250-G257
4. Sarri E., Ramos B., Salido G.M., et al. The cholecystokinin analogues JMV-180 and CCK-8 stimulate phospholipase C through the same binding site of CCK(A) receptor in rat pancreatic acini. Br J Pharmacol 133 8 (2001 Aug) 1227-1234
5. Ji B., Bi Y., Simeone D., et al. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology 121 6 (2001 Dec) 1380-1390
6. Ji B., Bi Y., Simeone D., et al. Human pancreatic acinar cells do not respond to cholecystokinin. Pharmacol Toxicol 91 6 (2002 Dec) 327-332
7. Galindo J., Jones N., Powell G.L., et al. Advanced qRT-PCR technology allows detection of the cholecystokinin 1 receptor (CCK1R) expression in human pancreas. Pancreas 31 4 (2005 Nov) 325-331
8. Owyang C., and Logsdon C.D. New insights into neurohormonal regulation of pancreatic secretion. Gastroenterology 127 3 (2004 Sep) 957-969
9. Kawabata A., Kuroda R., Nishida M., et al. Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Life Sci 71 20 (2002 Oct 4) 2435-2446
10. Nguyen T.D., Moody M.W., Steinhoff M., et al. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 103 2 (1999 Jan) 261-269
11. Sharma A., Tao X., Gopal A., et al. Protection against acute pancreatitis by activation of protease-activated receptor-2. Am J Physiol 288 2 (2005 Feb) G388-G395
12. Singh V.P., Bhagat L., Navina S., et al. Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion. Gut 56 7 (2007 Jul) 958-964
13. Sharma A., Tao X., Gopal A., et al. Calcium dependence of proteinase-activated receptor 2 and cholecystokinin-mediated amylase secretion from pancreatic acini. Am J Physiol 289 4 (2005 Oct) G686-G695
14. Gerasimenko O.V., Gerasimenko J.V., Rizzuto R.R., et al. The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium 32 5-6 (2002 Nov-Dec) 261-268
15. Gerasimenko J.V., Sherwood M., Tepikin A.V., et al. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci 119 Pt 2 (2006 Jan 15) 226-238
16. Pickett J.A., Thorn P., and Edwardson J.M. The plasma membrane Q-SNARE syntaxin 2 enters the zymogen granule membrane during exocytosis in the pancreatic acinar cell. J Biol Chem 280 2 (2005 Jan 14) 1506-1511
17. Wang C.C., Ng C.P., Lu L., et al. A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. Dev Cell 7 3 (2004 Sep) 359-371
18. Thorn P., and Parker I. Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents. J Physiol 563 Pt 2 (2005 Mar 1) 433-442
19. Muallem S., Kwiatkowska K., Xu X., et al. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells. J Cell Biol 128 4 (1995 Feb) 589-598
20. Bi Y., Page S.L., and Williams J.A. Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion. Am J Physiol 289 3 (2005 Sep) G561-G570
21. Bi Y., and Williams J.A. A role for Rho and Rac in secretagogue-induced amylase release by pancreatic acini. Am J Physiol Cell Physiol 289 1 (2005 Jul) C22-C32
22. Torgerson R.R., and McNiven M.A. The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing. J Cell Sci 111 Pt 19 (1998 Oct) 2911-2922
23. Lee M., Chung S., Uhm D.Y., et al. Regulation of zymogen granule exocytosis by Ca2+, cAMP, and PKC in pancreatic acinar cells. Biochem Biophys Res Commun 334 4 (2005 Sep 9) 1241-1247
24. Kruger B., Albrecht E., and Lerch M.M. The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. Am J Pathol 157 1 (2000 Jul) 43-50
25. Mooren F., Hlouschek V., Finkes T., et al. Early changes in pancreatic acinar cell calcium signaling after pancreatic duct obstruction. J Biol Chem 278 11 (2003 Mar 14) 9361-9369
26. Mooren F.C., Turi S., Gunzel D., et al. Calcium-magnesium interactions in pancreatic acinar cells. Faseb J 15 3 (2001 Mar) 659-672
27. Husain S.Z., Prasad P., Grant W.M., et al. The ryanodine receptor mediates early zymogen activation in pancreatitis. Proceed Natl Acad Sci U S A 102 40 (2005 Oct 4) 14386-14391
28. Chaudhuri A., Kolodecik T.R., and Gorelick F.S. Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell. Am J Physiol 288 2 (2005 Feb) G235-G243
29. Hofbauer B., Saluja A.K., Lerch M.M., et al. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol 275 2 Pt 1 (1998 Aug) G352-G362
30. Kruger B., Lerch M.M., and Tessenow W. Direct detection of premature protease activation in living pancreatic acinar cells. Lab Invest J Tech Methods Pathol 78 6 (1998 Jun) 763-764
31. Steer M.L., and Meldolesi J. The cell biology of experimental pancreatitis. New Engl J Med 316 3 (1987 Jan 15) 144-150
32. Kukor Z., Mayerle J., Kruger B., et al. Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis. J Biol Chem 277 24 (2002 Jun 14) 21389-21396
33. Halangk W., Lerch M.M., Brandt-Nedelev B., et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 106 6 (2000 Sep) 773-781
34. Mahurkar S., Idris M.M., Reddy D.N., et al. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut 55 9 (2006 Sep) 1270-1275
35. Weiss F.U., Behn C.O., Simon P., et al. Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in Western patients. Gut 56 9 (2007)
36. Lerch M.M., and Halangk W. Human pancreatitis and the role of cathepsin B. Gut 55 9 (2006 Sep) 1228-1230
37. Kuwata K., Hirota M., Shimizu H., et al. Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution. J Gastroenterol 37 11 (2002) 928-934
38. Masamune A., Kume K., Takagi Y., et al. N34S mutation in the SPINK1 gene is not associated with alternative splicing. Pancreas 34 4 (2007 May) 423-428
39. Ohmuraya M., Hirota M., Araki M., et al. Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology 129 2 (2005 Aug) 696-705
40. Ohmuraya M., Hirota M., Araki K., et al. Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3. Pancreas 33 1 (2006 Jul) 104-106
41. Kiraly O., Wartmann T., and Sahin-Toth M. Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. Gut (2007 May 24)
42. Boulling A., Le Marechal C., Trouve P., et al. Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. Eur J Hum Genet 15 9 (2007 Sep) 936-942
43. Kiraly O., Boulling A., Witt H., et al. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat 28 5 (2007 May) 469-476
44. Weiss F.U., Simon P., Witt H., et al. SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. J Med Genet 40 4 (2003 Apr) e40
45. Archer H., Jura N., Keller J., et al. A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology 131 6 (2006 Dec) 1844-1855
46. Selig L., Sack U., Gaiser S., et al. Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen. BMC Gastroenterol 6 (2006) 30
47. Simon P., Weiss F.U., Sahin-Toth M., et al. Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 → Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem 277 7 (2002 Feb 15) 5404-5410
48. Teich N., Le Marechal C., Kukor Z., et al. Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2). Hum Mutat 23 1 (2004 Jan) 22-31
49. Halangk W., Kruger B., Ruthenburger M., et al. Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation. Am J Physiol 282 2 (2002 Feb) G367-G374
50. Rinderknecht H., Adham N.F., Renner I.G., et al. A possible zymogen self-destruct mechanism preventing pancreatic autodigestion. Int J Pancreatol 3 1 (1988 Jan-Feb) 33-44
51. Whitcomb D.C., Gorry M.C., Preston R.A., et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 14 2 (1996 Oct) 141-145
52. Kukor Z., Toth M., and Sahin-Toth M. Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem/FEBS 270 9 (2003 May) 2047-2058
53. Sahin-Toth M., and Toth M. Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen. Biochem Biophys Res Commun 278 2 (2000 Nov 19) 286-289
54. Szmola R., and Sahin-Toth M. Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y. Proceed Natl Acad Sci U S A 104 27 (2007 Jul 3) 11227-11232
55. Sherwood M.W., Prior I.A., Voronina S.G., et al. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci U S A 104 13 (2007 Mar 27) 5674-5679
56. Mareninova O.A., Sung K.F., Hong P., et al. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem 281 6 (2006 Feb 10) 3370-3381
57. Wang Y.L., Hu R., Lugea A., et al. Ethanol feeding alters death signaling in the pancreas. Pancreas 32 4 (2006 May) 351-359
58. Bhatia M., Wallig M.A., Hofbauer B., et al. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis. Biochem Biophys Res Commun 246 2 (1998 May 19) 476-483
59. Cao Y., Adhikari S., Ang A.D., et al. Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. Am J Physiol 291 1 (2006 Jul) G95-G101
60. Cao Y., Adhikari S., Clement M.V., et al. Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. Am J Pathol 170 5 (2007 May) 1521-1534