Theoretical study of catalytic efficiency of a diels-alderase catalytic antibody: An indirect effect produced during the maturation process

Chemistry - A European Journal

Volumn 14, Issue 2, 2008, Pages 596-602

  Martí, Sergio ^a   Andrés, Juan ^a   Moliner, Vicent ^a   Silla, Estanisiao ^b   Tuñón, Iñaki ^b   Bertrán, Juan ^c  

^a UNIVERSITAT JAUME I   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Antibodies; Diels Alder reactions; Energy calculations; Mutatgenesis; Quantum mechanics molecular mechanics

Indexed keywords

CATALYSIS; ENZYME ACTIVITY; MUTAGENESIS; REACTION KINETICS;

CATALYTIC RATE CONSTANT; DIELS-ALDER REACTION; ENERGY CALCULATIONS; THERAPEUTICS AGENTS;

ANTIBODIES;

CATALYTIC ANTIBODY;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; MUTATION; QUANTUM THEORY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ANTIBODIES, CATALYTIC; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; GERM-LINE MUTATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTUM THEORY;

EID: 38149051405     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200700290     Document Type: Article

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