A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 682-687

  Feng, Dong Mei ^a   DiPardo, Robert M ^a   Wai, Jenny M ^a   Chang, Ronald K ^a   Di Marco, Christina N ^a   Murphy, Kathy L ^a   Ransom, Richard W ^a   Reiss, Duane R ^a   Tang, Cuyue ^a   Prueksaritanont, Thomayant ^a   Pettibone, Douglas J ^a   Bock, Mark G ^a   Kuduk, Scott D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bradykinin; GPCR; P glycoprotein; Pain; PXR

Indexed keywords

BRADYKININ B1 RECEPTOR ANTAGONIST; CYTOCHROME P450; DIFLUOROETHYL ETHER; ETHER DERIVATIVE; ISOXAZOLE DERIVATIVE; ISOXAZOLECARBOXAMIDE; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INDUCTION; EX VIVO STUDY; NONHUMAN; RAT; RECEPTOR OCCUPANCY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; HUMANS; ISOXAZOLES; MACACA MULATTA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B1; RECEPTORS, STEROID;

EID: 38149014699     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.057     Document Type: Article

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