Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate

International Archives of Occupational and Environmental Health

Volumn 81, Issue 4, 2008, Pages 429-441

  Littorin, Margareta ^a   Hou, Saimei ^b   Broberg, Karin ^a   Björk, Jonas ^a   Fät, Susanne ^b   Abdoulaye, Galbani ^b   Kalemba, Malgorzata ^a   Ryk, Charlotta ^b   Skerfving, Staffan ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Airways; Biomarkers; Genes; Isocyanates; Polymorphism

Indexed keywords

ALANINE; ARYLAMINE ACETYLTRANSFERASE; BIOLOGICAL MARKER; DIPHENYLMETHANE 4,4' DIISOCYANATE; DNA; GLUE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M3; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; ISOLEUCINE; POLYURETHAN;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MODIFICATION; EYE DISEASE; FEMALE; GAS CHROMATOGRAPHY; GENE INTERACTION; GENETIC TRAIT; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN EXPERIMENT; INDUSTRIAL WORKER; INTERVIEW; LUNG FUNCTION TEST; MALE; MASS SPECTROMETRY; NOSE DISEASE; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; QUESTIONNAIRE; RESPIRATORY TRACT DISEASE; RISK ASSESSMENT; SPIROMETRY; URINALYSIS;

ADULT; AGE FACTORS; ARYLAMINE N-ACETYLTRANSFERASE; BIOTRANSFORMATION; FEMALE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOGLOBULIN G; ISOCYANATES; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYURETHANES; RESPIRATORY FUNCTION TESTS; RESPIRATORY TRACT DISEASES; TIME FACTORS;

EID: 38049187887     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-007-0232-x     Document Type: Article

References (59)

1. American Thoracic Society (1987) Standardisation of spirometry: 1987 update. Am Rev Respir Dis 136:1285-1298
2. Anttila S, Hirvonen A, Vainio H, Husgafvel-Pursiainen K, Hayes JD, Ketterer B (1993) Immunohistochemical localization of glutathione S-transferases in human lung. Cancer Res 53:5643-5648
3. Barnes PJ (1990) Reactive oxygen species and airway inflammation. Free Radic Biol Med 9:235-243
4. Baur X, Marek W, Ammon J, Czuppon AB, Marczynski B, Raulf-Heimsoth M, Roemmelt H, Fruhmann G (1994) Respiratory and other hazards of isocyanates. Int Arch Occup Environ Health 66:141-152
5. Beghe B, Padoan M, Moss CT, Barton SJ, Holloway JW, Holgate ST, Howell WM, Mapp CE (2004) Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma. Allergy 59:61-64
6. Berglund E, Birath G, Bjure J, Grimby G, Kjellmer I, Sandqvist L, Söderholm B (1963) Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand 173:185-191
7. Berode M, Jost M, Ruegger M, Savolainen H (2005) Host factors in occupational diisocyanate asthma: A Swiss longitudinal study. Int Arch Occup Environ Health 78:158-163
8. Bolognesi C, Baur X, Marczynski B, Norppa H, Sepai O, Sabbioni G (2001) Carcinogenic risk of toluene diisocyanate and 4,4′-methylenediphenyl diisocyanate: Epidemiological and experimental evidence. Crit Rev Toxicol 31:737-772
9. Brown WE, Wold F (1971) Alkyl isocyanates as active site-specific inhibitors of chymotrypsin and elastase. Science 174:608-610
10. Cascorbi I, Brockmöller J, Mrozikiewicz PM, Müller A, Roots I (1999) Arylamine N-acetyltransferase activity in man. Drug Met Rev 31:489-502
11. Culp SJ, Roberts DW, Talaska G, Lang NP, Fu PP, Lay JO Jr, Teitel CH, Snawder JE, Von Tungeln LS, Kadlubar FF (1997) Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation. Mutat Res 378:97-112
12. Dalene M, Jakobsson K, Rannug A, Skarping G, Hagmar L (1996) MDA in plasma as a biomarker of exposure to pyrolysed MDI-based polyurethane: correlations with estimated cumulative dose and genotype for N-acetylation. Int Arch Occup Environ Health 68:165-169
13. Dalene M, Skarping G, Lind P (1997) Workers exposed to thermal degradation products of TDI and MDI based polyurethane: Biomonitoring of 2,4-TDA, 2,6-TDA, and 4,4′-MDA in hydrolysed urine and plasma. Am Ind Hyg Assoc J 58:587-591
14. Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA (2000) Polymorphism at the glutathione s-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med 161:1437-1442
15. Garte S (2001) Metabolic susceptibility genes as cancer risk factors: time for a reassessment? Cancer Epidemiol Biomarkers Prev 10:1233-1237
16. Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Benthamou S, Boffetta P, Bouchardy C, Breskvar K, Brockmoller J, Cascorbi I, Clapper ML, Coutelle C, Daly A, Dell-Omo M, Dolzan V, Dresler CM, Fryer A, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh LL, Ingelman-Sundberg M, Kalina I, Kang D, Kihara M, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, van Lieshout EM, London S, Manni JJ, Maugard CM, Morita S, Nazar-Stewart V, Noda K, Oda Y, Parl FF, Pastorelli R, Persson I, Peters WH, Rannug A, Rebbeck T, Risch A, Roelandt L, Romkes M, Ryberg D, Salagovic J, Schoket B, Seidegard J, Shields PG, Sim E, Sinnet D, Strange RC, Stucker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Taioli E (2001) Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev 2001 10:1239-1248
17. Gauderman WJ (2002) Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 155:478-484
18. Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L (2002) Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. Am J Respir Crit Care Med 166:710-716
19. Gledhill A, Wake A, Hext P, Leibold E, Shiotsuka R (2005) Absorption, distribution, metabolism and excretion of an inhalation dose of [14C] 4,4′-methylenediphenyl diisocyanate in the male rat. Xenobiotica 35:273-292
20. Grant DM, Blum M, Meyer UA (1992) Polymorphisms of N-acetyltransferase genes. Xenobiotica 22:1073-1081
21. Hayes JD, Strange RC (1995) Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radic Res 22:193-207
22. He JQ, Connett JE, Anthonisen NR, Pare PD, Sandford AJ (2004) Glutathione S-transferase variants and their interaction with smoking on lung function. Am J Respir Crit Care Med 170:388-394
23. Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xiao GH, Devanaboyina US, Nangju NA, Feng Y (2000) Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomarkers Prev 9:29-41
24. Hou S-M, Lambert B, Hemminki K (1995) Relationship between hprt mutant frequency, aromatic DNA adducts and genotypes for GSM1 and NAT2 in bus maintenance workers. Carcinogenesis 16:1913-1917
25. Jakobsson K, Rannug A, Alexandrie A-K, Rylander L, Hagmar L (1997) Airway symptoms and lung function in pipe-layers exposed to MDI-based polyurethane pyrolysis products and welding fumes do not relate to host polymorphism for CYP1A1, GSTM1 and NAT2. Biomarkers 2:57-62
26. Johannesson G, SennbroCJ, Willix P, Lindh CH, Jonsson BA (2004a) Identification and characterisation of adducts between serum albumin and 4,4′-methylenediphenyl diisocyanate (MDI) in human plasma. Arch Toxicol 78:378-383
27. Johannesson G, Lindh C, Nielsen J, Bjork B, Rosqvist S, Jonsson BA (2004b) In vivo conjugation of nasal lavage proteins by hexahydrophthalic anhydride. Toxicol Appl Pharmacol 194:69-78
28. Kadlubar FF (1994) Biochemical individuality and its implications for drug and carcinogen metabolism: Recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans. Drug Metab Rev 26:37-46
29. Kautiainen A, Wachtmeister CA, Ehrenberg L (1998) Characterization of hemoglobin adducts from a 4,4′-methylenedianiline metabolite evidently produced by peroxidative oxidation in vivo. Chem Res Toxicol 11:614-621
30. Kelly FJ (2003) Oxidative stress: Its role in air pollution and adverse health effects. Occup Environ Med 60:612-616
31. Kim SH, Oh HB, Lee KW, Shin ES, Kim CW, Hong CS, Nahm DH, Park HS (2006) HLA DRB1*15-DPB1*05 haplotype: A susceptible gene marker for isocyanate-induced occupational asthma? Allergy 61:891-894
32. Kleeberger SR, Peden D (2005) Gene-environment interactions in asthma and other respiratory diseases. Annu Rev Med 56:383-400
33. Lange RW, Day BW, Lemus R, Tyurin VA, Kagan VE, Karol MH (1999) Intracellular S-glutathionyl adducts in murine lung and human bronchoepithelial cells after exposure to diisocyanatotoluene. Chem Res Toxicol 12:931-936
34. Lantz RC, Lemus R, Lange RW, Karol MH (2001) Rapid reduction of intracellular glutathione in human bronchial epithelial cells exposed to occupational levels of toluene diisocyanate. Toxicol Sci 60:348-355
35. Lind P, Dalene M, Tinnerberg H, Skarping G (1997) Biomarkers in hydrolysed urine, plasma and erythrocytes among workers exposed to thermal degradation products from toluene diisocyanate foam. Analyst 122:51-56
36. Littorin M, Rylander L, Skarping G, Dalene M, Welinder H, Strömberg U, Skerfving S (2000) Exposure biomarkers and risk at gluing and heating of polyurethane - a cross-sectional study of respiratory symptoms. Occup Environ Med 57:396-405
37. Littorin M, Welinder H, Skarping G, Dalene M, Skerfving S (2002) Exposure and nasal inflammation in workers heating polyurethane. Int Arch Occup Environ Health 75:468-474
38. Liu Q, Wisnewski AV (2003) Recent developments in diisocyanate asthma. Ann Allergy Asthma Immunol 90(Suppl):35-41
39. Mapp CE, Beghe B, Balboni A, Zamorani G, Padoan M, Jovine L, Baricordi OR, Fabbri LM (2000) Association between HLA genes and susceptibility to toluene diisocyanate-induced asthma. Clin Exp Allergy 16:570-572
40. Mapp CE, Fryer AA, De Marzo N, Pozzato V, Padoan M, Boschetto P, Strange RC, Hemmingsen A, Spiteri MA (2002) Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates. J Allergy Clin Immunol 109:867-872
41. Mapp CE, Boschetto P, Miotto D, De Rosa E (2005) Asthma induced by isocyanates: A model of IgE-independent asthma. Acta Biomed Ateneo Parmense 76(Suppl 2):15-9
42. Park HS, Lee SK, Kim HY, Nahm DH, Kim SS (2002) Specific immunoglobulin E and immunoglobulin G antibodies to toluene diisocyanate-human serum albumin conjugate: Useful markers for predicting long-term prognosis in toluene diisocyanate-induced asthma. Clin Exp Allergy 32:551-555
43. Pelkonen O, Raunio H, Rautio A, Lang M. Chapter 8 (1999) Xenobiotic-metabolizing enzymes and cancer risk: Correspondence between genotype and phenotype. In: Vineis P, Malats N, Lang M, d'Erricio A, Caporaso N, Cuzick J, Boffetta P (eds) Metabolic polymorphisms and susceptibility to cancer. Lyon: International Agency for Research on Cancer (IARC); p 77-88. IARC scientific publications, no 148
44. Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB (1994) Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300:271-276
45. Piirilä P, Wikman H, Luukkonen R, Kääriä K, Rosenberg C, Nordman H, Norppa H, Vainio H, Hirvonen A (2001) Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure. Pharmacogenetics 437-445
46. Raulf-Heimsoth M, Baur X (1998) Pathomechanisms and pathophysiology of isocyanate-induced diseases-summary of present knowledge. Am J Ind Med 34:137-143
47. Rihs HP, Barbalho-Krölls T, Huber H, Baur X (1997) No evidence for the influence of HLA Class II in alleles in isocyanate-induced asthma. Am J Ind Med 32:522-527
48. Savolainen H (1999) New mechanistic model for organic diisocyanate-induced respiratory disease. Schweiz Med Wochenschr 129:465-467
49. Schutze D, Sepai O, Lewalter J, Miksche L, Henschler D, Sabbioni G (1995) Biomonitoring of workers exposed to 4,4′-methylenedianiline or 4,4′-methylenediphenyl diisocyanate. Carcinogenesis 16:573-582
50. Schwartzbaum JA, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, Christensen HC, Henriksson R, Johansen C, Lindholm C, Malmer B, Salminen T, Schoemaker MJ, Swerdlow AJ, Feychting M (2007) An international case-control study of glutathione transferase, functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev 16(3):559-565
51. Sepai O, Henschler D, Sabbioni G (1995) Albumin adducts, hemoglobin adducts and urinary metabolites in workers exposed to 4,4′-methylene diisocyanate. Carcinogenesis 16:2583-2587
52. Sipes IG, Gandolfi AJ (1991) Biotransformation of toxicants. In: Amdur MO, Doull J, Klaassen CD (eds) Casarett and Doull's Toxicology. Pergamon Press, New York, pp 88-126
53. Skarping G, Dalene M, Littorin M (1995) 4,4′-methylenedianiline in hydrolysed serum and urine from a worker exposed to thermal degradation products of methylene diphenyl diisocyanate elastomers. Int Arch Occup Environ Health 67:73-77
54. Skarping G, Dalene M, Svensson B-G, Littorin M, Åkesson B, Welinder H, Skerfving S (1996) Biomarkers of exposure, antibodies, and respiratory symptoms in workers heating polyurethane glue. Occup Environ Med 53:180-187
55. Tamer L, Calikoglu M, Ates NA, Yildirim H, Ercan B, Saritas E, Unlu A, Atik U (2004) Glutathione-S-transferase gene polymorphisms (GSTT1, GSTM1, GSTP1) as increased risk factors for asthma. Respirology 9:493-498
56. Vineis P, Malats N, Lang M, d'Erricio A, Caporaso N, Cuzick J, Boffetta P (eds) (1999) Metabolic polymorphisms and susceptibility to cancer.Lyon: International Agency for Research on Cancer (IARC). IARC scientific publications no 148
57. Wikman H, Piirilä P, Rosenberg C, Luukkonen R, Kääriä K, Nordman H, Norppa H, Vainio H, Hirvonen A (2002) N-acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk. Pharmacogenetics 12:227-233
58. Windmill KF, Gaedigk A, Hall PM, Samaratunga H, Grant DM, McManus ME (2005) Localization of N-acetyltransferases NAT1 and NAT2 in human tissues. Toxicol Sci 54:19-29
59. Wisnewski AV, Liu Q, Liu J, Redlich CA (2005) Glutathione protects human airway proteins and epithelial cells from isocyanates. Clin Exp Allergy 35:352-357