Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure

Pharmacogenetics

Volumn 11, Issue 5, 2001, Pages 437-445

  Piirila P ^a   Wikman, H ^a   Luukkonen, R ^a   Kaaria K ^a   Rosenberg, C ^a   Nordman, H ^a   Norppa, H ^a   Vainio, H ^a   Hirvonen, A ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

Allergic responses; Diisocyanates; GSTs; Individual susceptibility; Occupational asthma; Specific IgE

Indexed keywords

ALLERGEN; ANTIBODY; CYANIC ACID DERIVATIVE; GENE PRODUCT; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M3; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; IMMUNOGLOBULIN E; TOLUENE DIISOCYANATE; UNCLASSIFIED DRUG;

ADULT; ALLERGY; ARTICLE; CONJUGATION; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL ASTHMA; OCCUPATIONAL EXPOSURE; POPULATION RESEARCH; PRIORITY JOURNAL; PROVOCATION TEST; RISK;

ADULT; ASTHMA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; ISOCYANATES; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE;

EID: 0034948080     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200107000-00007     Document Type: Article

References (35)

1. Glutathione: A vehicle for the transport of chemically reactive metabolites in vivo
2. Association between toluene diisocyanate-induced asthma and DQB1 markers: A possible role for aspartic acid at position 57
3. Reactive oxygen species and airway inflammation
4. Immunologic cross-reactivity between different albumin-bound isocyanates
5. Respiratory and other hazards of isocyanates
6. T-cell receptor Vb gene segment expression in diisocyanate-induced occupational asthma
7. HLA class II alleles in isocyanate-induced asthma
8. Longitudinal study of workers employed in the manufacture of toluene-di-isocyanate
9. Radioallergosorbent testing of toluene diisocyanate-reactive individuals using p-tolyl isocyanate antigen
10. Specific serum antibodies against isocyanates: Association with occupational asthma
11. Occupational asthma
12. Formation, solvolysis, and transcarbamoylation reactions of his (S-glutathionyl) adducts of 2,4- and 2,6-diisocyanatotoluene
13. Polymorphism at the glutathione S-transferase GSTP1 locus: A new marker for bronchial hyperresponsiveness and asthma
14. Molecular structure of 1.8 Å of mouse liver class pi glutathione S-transferase complex with s-(p-nitrobenzyl) glutathione and other inhibitors
15. Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress
16. Polymorphism of xenobiotic-metabolizing enzymes and susceptibility to cancer
17. Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: Evidence for linkage with GSTM1* A
18. Skin testing for immediate hypersensitivity in occupational allergology
19. Experiences of specific IgE in asthma due to diisocyanates
20. Occupational asthma due to isocyanates
21. Association of polymorphism in the glutathione S-transferase, GSTM1, GSTM3, GSTP1 and GSTT1 loci with susceptibility and outcome in rheumatoid arthritis
22. Inhalation challenge testing
23. Association of homozygosity for glutathione Stransferase, GSTM1 null alleles is associated with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus
24. Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)-cysteine, two electrophilic S-linked conjugates of methyl isocyanate
25. Specific IgE antibodies in 28 workers with di-isocyanate induced bronchial asthma
26. Long-term follow-up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma
27. Combined effect of polymorphic GST genes on individual susceptibility to lung cancer
28. Airway mucosal inflammation in occupational asthma induced by toluene diisocyanate
29. Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities
30. The glutathione S-transferases: Influence of polymorphism on susceptibility to non familial cancers
31. Specific IgE to isocyanates: A useful diagnostic role in occupational asthma
32. Immunologic specificity of isocyanate-induced IgE antibodies in serum from 10 sensitized workers
33. Issues in phenotype assessment
34. Polymorphism at the glutathione-S transferase locus GSTM3: Interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma
35. Naturally occurring human glutathione S-transferase GSTP1 isoforms with isoleucine and valine at position 104 differ in enzymatic properties