Biomarkers of exposure, antibodies, and respiratory symptoms in workers heating polyurethane glue

Occupational and Environmental Medicine

Volumn 53, Issue 3, 1996, Pages 180-187

  Skarping, G ^a   Dalene, M ^a   Svensson, B G ^a   Littorin, M ^a   Akesson B ^a   Welinder, H ^a   Skerfving, S ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Biomarkers; Polyurethane glue

Indexed keywords

BIOCHEMICAL MARKER; GLUE; ISOCYANATE; POLYURETHAN;

ADULT; AIR ANALYSIS; ANTIBODY DETECTION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL LUNG DISEASE; PRIORITY JOURNAL; RISK ASSESSMENT; SERUM; SWEDEN; SYMPTOM;

EID: 0029947350     PISSN: 13510711     EISSN: None     Source Type: Journal    
DOI: 10.1136/oem.53.3.180     Document Type: Article

References (33)

1. Hagmar L, Nielsen J, Skerfving S. Clinical features and epidemiology of occupational obstructive disease caused by small molecular weight organic chemicals. Monogr Allergy 1987;21:42-58.
2. Kennedy AL, Brown WE. Isocyanates and lung disease: experimental approaches to molecular mechanisms. Occupational medicine: state of the art review. Philadelphia: Hanley and Belfus, 1992;7:301.
3. Vandenplas O, Malo J-L, Saetta M, Mapp CE, Fabbri LM. Occupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives. Br J Ind Med 1993;50:213-28.
4. Littorin M, Truedsson L, Welinder H, Skarping G, Mårtensson U, Sjöholm AG. Acute respiratory disorder, rhinoconjunctivitis, and fever associated with pyrolysis of polyurethane derived from MDI. Scand J Work Environ Health 1994;20:216-22.
5. Skarping G, Renman L, Sangö C, Mathiasson L, Dalene M. Capillary gas chromatographic method for the determination of complex mixture of isocyanates and amines. J Chromatogr 1985;346:191-204.
6. Renman L, Sangö C, Skarping G. Determination of isocyanate and aromatic amine emissions from thermally degraded polyurethane's in foundries. Am Ind Hyg Assoc J 1986;47:621-8.
7. Rosenberg C, Savolainen H. Mass fragmentographic determination of urinary amine metabolites in rats exposed to degradation products from heated rigid polyurethane. J Chromatogr 1986;358:385-91.
8. Dalene M, Mathiasson L, Skarping G, Sangö C, Sandström JF. Trace analysis of airborne aromatic isocyanates and related aminoisocyanates and diamines using high-performance liquid chomatography with ultraviolet and electrochemical detection. J Chromatogr 1988;435:469-81.
9. Dalene M, Skarping G, Brorson T. Chromatographic determination of amines in biological fluids with special reference to the biological monitoring of isocyanates and amines. IV. Determination of 1,6-hexamethylene diamine (HDA) in humane urine using capillary gas chromatography and selective ion monitoring. J Chromatogr 1990;516:405-13.
10. Sandström J, Skarping G, Dalene M. Chromatographic determination of amines in biological fluids with special reference to The biological monitoring of isocyanates and amines. II. Determination of 2,4- and 2,6-toluenediamine (TDA) using glass capillary gas chromatography and selected ion monitoring (SIM). J Chromatogr 1989; 479:135-43.
11. Skarping G, Dalene M, Persson P. Biological monitoring of 2,4- and 2,6-toluenediisocyanate using capillary gas chromatography and selected ion monitoring. J Chromatogr 1994;663:199-200.
12. Kopelman H, Robertsson MH, Sanders PG, Ash I. The Epping jaundice. BMJ 1966;1:514-6.
13. Skarping G, Dalene M. Determination of 4,4′-methylenedianiline (MDA) and identification of isomers in technical-grade MDA in hydrolysed plasma and urine from workers exposed to methylene diphenyldiisocyanate by gas chromatography-mass spectrometry. J Cromatogr 1995;663:209-16.
14. Nielsen J, Welinder H, Schütz A, Skerfving S. Specific serum antibodies against phthalic anhydride in occupationally exposed subjects. J Allergy Clin Immunol 1988; 82:126-33.
15. Sangö C, Zimerson E. A new reagent for determination of isocyanates in working atmospheres by HPLC using UV or fluorescence detection. Journal of Liquid Chromatography 1990;2:971-90.
16. Welinder H, Nielsen J, Bensryd I, Skerfving S. IgG antibodies polyisocyanates in car painters. Clin Allergy 1988; 18:85-93.
17. Welinder H, Nielsen J. Immunologic tests of specific antibodies to organic acid anhydrides. Allergy 1991;46: 601-9.
18. Aas K, Belin L. Standardization of diagnostic work in allergy. Int Arch Allergy 1973;45:57-60.
19. National Swedish Occupational Safety and Health Administration (Abetarskyddsstyrelsen). Occupational permissible exposure limits (Hygieniska gränsvärden). Stockholm: AFS 1993;9:86.
20. Skarping G, Dalene M, Mathiasson M. Trace analysis of airborne 1,6-hexamethylene diisocyanate and the related aminoisocyanate and diamine by glass capillary gas chromatography. J Chromatogr 1988;435:453-68.
21. Skarping G, Dalene M, Brunmark P. Liquid chromatography and mass spectrometry determination of aromatic amines in hydrolysed urine from workers exposed to thermal degradation products of polyurethane. Cromatographia 1994;39:619-23.
22. Brorson T, Skarping G, Sangö C. Biological monitoring of isocyanates and related amines. FV: 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluenediisocyanate. Int Arch Occup Environ Health 1991;63:253-9.
23. Skarping G, Brorson T, Sangö C. Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate (TDI). Int Arch Occup Environ Health 1991;63:83-8.
24. Persson P, Dalene M, Skarping G, Adamsson M, Hagmar L. Determination of occupational exposure to toluenediisocyanate by biological monitoring in urine and plasma by gas chromatography-mass spectrometry. Br J Ind Med 1993;50:1111-8.
25. Seldén AI, Belin L, Wass U. Isocyanate exposure and hypersensitivity pneumonitis- report of a probable case and prevalence of specific immunoglobulin G antibodies among exposed individuals. Scand J Work Environ Health 1989;15:234-344.
26. Brunmark P, Bruze M, Skerfving S, Skarping G. Biomonitoring of 4,4′-methylene dianiline by measurement in hydrolysed urine and plasma after epicutaneous exposure in humans. Int Arch Occup Environ Health 1995; 67:73-7.
27. Baur X, Marek W, Ammon J, Czuppon AB, Marcynski B, Raul-Heimsoth M, et al. Respiratory and other hazards of isocyanates. Int Arch Occup Environ Health 1994;66: 141-52.
28. Grammer LC, Eggum P, Silverstein M, Shaughnessy MA, Liotta JL, Patterson R. Prospective immunologic and clinical study of a population exposed to hexamethylene diisocyanate. J Allergy Clin Immunol 1988;82:627-33.
29. Baur X, Dewair M, Fruhmann G. detection of immunologically sensitised isocyanate workers by RAST and intracutaneous skin tests. J Allergy Clin Immunol 1984;73: 610-8.
30. Cartier A, Grammer L, Malo JL, Lagier F, Ghezzo H, Harris K, Patterson R. Specific serum antibodies against isocyanates: association with occupational asthma. J Allergy Clin Immunol 1989;84:507-14.
31. Welinder H, Nielsen J, Gustavsson C, Bensryd I, Skerfving S. Specific antibodies to methyltetrahydrophthalic anhydride in exposed workers. Clin Allergy 1990;20:639-45.
32. Welinder HE, Jönsson BAG, Nielsen J, Ottosson HE, Gustavsson CA. Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers. Scand J Work Environ Health 1994;20:459-65.
33. Salvaggio JE. Recent advances in pathogenesis of allergic alveolitis. Clin Exp Allergy 1990;20:137-44.