Characterization of a novel bifunctional mutant of staphylokinase with platelet-targeted thrombolysis and antiplatelet aggregation activities

BMC Molecular Biology

Volumn 8, Issue , 2007, Pages

  Chen, Hongshan ^a,b   Mo, Wei ^a   Su, Huabo ^a   Zhang, Yanling ^a   Song, Houyan ^a  

^a FUDAN UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; MUTANT PROTEIN; STAPHYLOKINASE; ANTITHROMBOCYTIC AGENT; ARGININE; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; AUR PROTEIN, STAPHYLOCOCCUS AUREUS; FIBRINOLYTIC AGENT; METALLOPROTEINASE; OLIGOPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA SEQUENCE; ESCHERICHIA COLI; FIBRINOLYSIS; GENE OVEREXPRESSION; HUMAN; IN VITRO STUDY; MOLECULAR CLONING; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PURIFICATION; PROTEIN TARGETING; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; THROMBOCYTE AGGREGATION INHIBITION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BIOREACTOR; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; FIBRINOLYTIC THERAPY; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; METHODOLOGY; MICROBIOLOGY; MOLECULAR WEIGHT; MOUSE; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE; THROMBOCYTE; THROMBOCYTE AGGREGATION; TIME;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BIOREACTORS; BLOOD PLATELETS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FIBRINOLYSIS; FIBRINOLYTIC AGENTS; HUMANS; KINETICS; METALLOENDOPEPTIDASES; MICE; MOLECULAR WEIGHT; OLIGOPEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ANALYSIS, DNA; THROMBOLYTIC THERAPY; TIME FACTORS;

EID: 38049177399     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-8-88     Document Type: Article

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