Alternative mRNA splicing of SAP30L regulates its transcriptional repression activity

FEBS Letters

Volumn 582, Issue 2, 2008, Pages 379-384

  Korkeamäki, Hanna ^a   Viiri, Keijo ^a   Kukkonen, Mari K ^b   Mäki, Markku ^a   Lohi, Olli ^a  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^b FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

Histone; Repression; SAP30L; Splicing; Transcription

Indexed keywords

HISTONE DEACETYLASE; SIN3A ASSOCIATED PROTEIN 30L; TRANSCRIPTION FACTOR SIN3A; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; RNA SPLICING; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; BASE SEQUENCE; CELL LINE; DNA PRIMERS; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; NUCLEAR PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 38049080088     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.11.084     Document Type: Article

References (10)

1. Strahl B.D., and Allis C.D. The language of covalent histone modifications. Nature 403 (2000) 41-45
2. Shiio Y., and Eisenman R.N. Histone sumoylation is associated with transcriptional repression. Proc. Natl. Acad. Sci. USA 100 (2003) 13225-13230
3. Berger S.L. Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12 (2002) 142-148
4. Kuo M.H., and Allis C.D. Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 20 (1998) 615-626
5. Ferreira R., Naguibneva I., Mathieu M., Ait-Si-Ali S., Robin P., Pritchard L.L., and Harel-Bellan A. Cell cycle-dependent recruitment of HDAC-1 correlates with deacetylation of histone H4 on an Rb-E2F target promoter. EMBO Rep. 2 (2001) 794-799
6. Silverstein R.A., and Ekwall K. Sin3: a flexible regulator of global gene expression and genome stability. Curr. Genet. 47 (2005) 1-17
7. Zhang Y., Sun Z.W., Iratni R., Erdjument-Bromage H., Tempst P., Hampsey M., and Reinberg D. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol. Cell 1 (1998) 1021-1031
8. Laherty C.D., Billin A.N., Lavinsky R.M., Yochum G.S., Bush A.C., Sun J.M., Mullen T.M., Davie J.R., Rose D.W., Glass C.K., Rosenfeld M.G., Ayer D.E., and Eisenman R.N. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol. Cell 2 (1998) 33-42
9. Lindfors K., Viiri K.M., Niittynen M., Heinonen T.Y., Maki M., and Kainulainen H. TGF-beta induces the expression of SAP30L, a novel nuclear protein. BMC Genomics 4 (2003) 53
10. Viiri K.M., Korkeamaki H., Kukkonen M.K., Nieminen L.K., Lindfors K., Peterson P., Maki M., Kainulainen H., and Lohi O. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucl. Acids Res. 34 (2006) 3288-3298