Thrombin peptide TP508 prevents nitric oxide mediated apoptosis in chondrocytes in the endochondral developmental pathway

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 1, 2008, Pages 12-22

  Zhong, M ^a   Wike, L J ^a   Ryaby, J T ^b   Carney, D H ^c   Boyan, B D ^a   Schwartz, Z ^a,d,e  

^a Emory University   (United States)

^b OrthoLogic Corporation   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Apoptosis; Chondrocytes; Endochondral ossification; Growth plate; Thrombin peptide; TP508

Indexed keywords

ASCORBIC ACID; CASPASE 3; CHELERYTHRINE; DNA FRAGMENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PEPTIDE; PHOSPHATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C; TAMOXIFEN; THROMBIN PEPTIDE 508; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL VIABILITY; CONTROLLED STUDY; EAR CARTILAGE; ENCHONDRAL OSSIFICATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; FEMALE; GROWTH PLATE; MALE; NICK END LABELING; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CHONDROCYTES; GENE EXPRESSION REGULATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEPTIDE FRAGMENTS; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; THROMBIN;

RATTUS;

EID: 38049022200     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2007.10.009     Document Type: Article

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