Novel bisindolylmaleimide derivative inhibits mitochondrial permeability transition pore and protects the heart from reperfusion injury

Canadian Journal of Physiology and Pharmacology

Volumn 85, Issue 10, 2007, Pages 979-985

  Katare, Rajesh Gopalrao ^a   Zhitian, Zou ^a   Sodeoka, Mikiko ^b   Sasaguri, Shiro ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

Apoptosis; Bisindolylmaleimide; Ischemia reperfusion; Mitochondria; PTP

Indexed keywords

(2 [1 (3 AMINOPROPYL)INDOL 3 YL] 3 (INDOL 3 YL) N METHYLMALEIMIDE; ATRACTYLOSIDE; BISINDOLYLMALEIMIDE; CASPASE 3; CYTOCHROME C; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE COURSE; DRUG ACTIVITY; DRUG EFFECT; ELECTROCARDIOGRAM; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART INFARCTION; HEART INFARCTION SIZE; HEART PERFUSION; HEART PROTECTION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; MONOTHERAPY; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; REPERFUSION INJURY;

ACUTE DISEASE; ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CASPASE 3; CYTOCHROMES C; DISEASE MODELS, ANIMAL; INDOLES; INFUSIONS, INTRAVENOUS; MALE; MALEIMIDES; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, WISTAR;

EID: 38049011757     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y07-071     Document Type: Article

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