Modeling and active site refinement for G protein-coupled receptors: Application to the β-2 adrenergic receptor

Journal of Computer-Aided Molecular Design

Volumn 20, Issue 7-8, 2006, Pages 463-470

  Krystek, Stanley R ^a   Kimura, S Roy ^a   Tebben, Andrew J ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Comparative modeling; GPCR; GPCR structure; Protein modeling

Indexed keywords

BINDING ENERGY; BIOLOGICAL MEMBRANES; CRYSTAL STRUCTURE;

ACTIVE SITE; ADRENERGIC RECEPTORS; BOVINE RHODOPSIN; COMPARATIVE MODELING; DRUG DISCOVERY; G PROTEIN COUPLED RECEPTORS; GPCR; GPCR STRUCTURE; PROTEIN MODELS; X RAY CRYSTAL STRUCTURES;

PROTEINS;

ASPARTIC ACID; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR; GLUTAMINE; LEUCINE; MEMBRANE PROTEIN; PROLINE; RHODOPSIN; SERINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG RESEARCH; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROCESS MODEL; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY;

EID: 37849188778     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/s10822-006-9065-z     Document Type: Article

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