Optimisation of halogenase enzyme activity by application of a genetic algorithm

Journal of Biotechnology

Volumn 127, Issue 3, 2007, Pages 425-433

  Muffler, Kai ^a   Retzlaff, Marco ^a   van Pée, Karl Heinz ^b   Ulber, Roland ^a  

^a University of Koblenz Landau   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Bromination; Enzymatic halogenation; Genetic algorithm; Halogenase; Optimisation

Indexed keywords

BIOASSAY; COMPOSITION; GENETIC ALGORITHMS; GENETIC ENGINEERING; HALOGENATION; OPTIMIZATION; STATISTICAL METHODS;

BROMINATION; ENZYMATIC HALOGENATION; HALOGENASE; SEROTONIN PRECURSORS;

ENZYMES;

ISOENZYME; TRYPTOPHAN; TRYPTOPHAN 5 HALOGENASE;

ALGORITHM; ARTICLE; BROMINATION; ENZYME ACTIVITY; ENZYME ASSAY; HALOGENATION; ISOENZYME ANALYSIS; PRIORITY JOURNAL; STOCHASTIC MODEL;

ALGORITHMS; DIRECTED MOLECULAR EVOLUTION; MODELS, CHEMICAL; MODELS, GENETIC; OXIDOREDUCTASES; SEROTONIN; SUBSTRATE SPECIFICITY; TRYPTOPHAN;

EID: 37849185258     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2006.07.008     Document Type: Article

References (27)

1. Adinarayana K., Ellaiah P., Srinivasulu B., Bhavani Devi R., and Adinarayana G. Response surface methodological approach to optimize the nutritional parameters for neomycin production by Streptomyces marinensis under solid-state fermentation. Process. Biochem. 38 (2003) 1565-1572
2. Azadivar F., and Talavage J.J. Optimization of stochastic simulation models. Math. Comput. Simulat. 22 (1980) 231-241
3. Bandi S., Kim Y.J., Sa S.O., and Chang Y.K. Statistical approach to development of culture medium for ansamitocin P-3 production with Actinosynnema pretiosum ATCC 31565. J. Microbiol. Biotechnol. 15 (2005) 930-937
4. Bosma R., van Spronsen W.A., Tramper J., and Wijffels R.H. Ultrasound, a new separation technique to harvest microalgae. J. Appl. Phycol. 15 (2003) 143-153
5. Cooper J.D.H., Odgen G., McIntosh J., and Turnell D.C. The stability of o-phthalaldehyd/2-mercaptoethanol derivates of amino acids: an investigation using high-pressure liquid chromatography with a precolumn derivatisation technique. Anal. Biochem. 142 (1984) 98-102
6. Dong C., Flecks S., Unversucht S., Haupt C., van Pée K.-H., and Naismith J.H. Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Science 309 (2005) 2216-2219
7. Fontecave M., Eliasson R., and Reichard P. NAD(P)H: flavin oxidoreductase of Escherichia coli. A ferric iron reductase participating in the generation of the free radical of ribonucleotide reductase. J. Biol. Chem. 262 (1987) 12325-12331
8. Freyer S., Weuster-Botz D., and Wandrey C. Nährmedienoptimierung mit Genetischen Algorithmen. Bioengineering 8 (1992) 16-25
9. Goldberg D.E. Genetic Algorithms (1989), Addison Wesley, New York
10. Gribble G.W. Amazing organohalogens. Am. Sci. 92 (2004) 342-349
11. Hammer P.E., Hill D.S., Lam S.T., van Pée K.-H., and Ligon J.M. Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin. Appl. Environ. Microbiol. 63 (1997) 2147-2154
12. Hasegawa M., Yamada K., Nagahama Y., and Somei M. The chemistry of indoles. Part 94. A novel methodology for preparing 5-chloro- and 5-bromotryptamines and tryptophans, and its application to the synthesis of (+/-)-bromochelonin B. Heterocycles 51 (1999) 2815-2821
13. Kadiyala V., and Spain J.C. A two-component monooxygenase catalyzes both the hydroxylation of p-nitrophenol and the oxidative release of nitrite from 4-nitrocatechol. Appl. Environ. Microbiol. 64 (1998) 2479-2484
14. Keller S., Wage T., Hohaus K., Hölzer M., Eichhorn E., and van Pée K.-H. Purification and partial characterization of tryptophan 7-halogenase (PrnA) from Pseudomonas fluorescens. Angew Chem. Int. Ed. 39 (2000) 2300-2302
15. Lee S.L., and Chen W.C. Optimization of medium composition for the production of glucosyltransferase by Aspergillus niger with response surface methodology. Enzyme Microb. Tech. 21 (1997) 436-440
16. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
17. Muffler K., and Ulber R. Application of different algorithms for growth optimization of marine bacterium (Halomonas marina). Mar. Biotechnol. 6 (2004) S262-S267
18. Rucka M., Lamer-Zarawska E., Maliszewska I., and Turkiewics B. Optimization of growth and hydrolytic enzyme production by Fusarium culmorum using response surface method. Bioprocess. Eng. 19 (1998) 229-232
19. Spyrou G., Haggard-Ljungquist E., Krook M., Jornvall H., Nilsson E., and Reichard P. Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme. J. Bacteriol. 173 (1991) 3673-3679
20. Ulber R., Protsch C., Solle D., Hitzmann B., Wilke B., Faurie R., and Scheper T. Use of bioanalytical systems for the improvement of industrial tryptophan production. Chem. Ing. Technol. 24 (2001) 15-17
21. Ulber R., 2002. Biotechnologische Methoden zur effizienteren Rohstoffnutzung, Professorial Dissertation, Hanover, Germany.
22. van Pée K.-H., and Patallo E.P. Flavin-dependent halogenases involved in secondary metabolism in bacteria. Appl. Microbiol. Biotechnol. 70 (2006) 631-641
23. Vankeerberghen P., Smeyers-Verbeke R., Leardi R., Karr C.L., and Massart D.L. Robust regression and outlier detection for non-linear models using genetic algorithms. Chemometr. Intell. Lab. 28 (1995) 73-87
24. Weuster-Botz D., and Wandrey C. Medium optimization by genetic algorithm for continuous production of formate dehydrogenase. Process. Biochem. 30 (1995) 563-571
25. Weuster-Botz D., Pramatarova V., Spassov G., and Wandrey C. Use of a genetic algorithm in the development of a synthetic growth medium for Arthrobacter simplex with high hydrocortisone Δ1-dehydrogenase activity. J. Chem. Technol. Biotechnol. 64 (1995) 386-392
26. Weuster-Botz D. Experimental design for fermentation media development: statistical design or global random search?. J. Biosci. Bioeng. 90 (2000) 473-483
27. Zehner S., Kotzsch A., Bister B., Sussmuth R.D., Méndez C., Salas J.A., and van Pée K.-H. A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. Chem. Biol. 12 (2005) 1-8