Autoimmunity since the 1957 clonal selection theory: A little acorn to a large oak

Immunology and Cell Biology

Volumn 86, Issue 1, 2008, Pages 67-71

  Mackay, Ian R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Autoepitope; Autoimmunity; Burnet; Clonal selection theory; Immune tolerance; Mutagenesis

Indexed keywords

AUTOANTIGEN; EPITOPE; GLUTAMATE DECARBOXYLASE 65;

ANTIGEN PRESENTING CELL; APOPTOSIS; AUTOIMMUNITY; CELL CLONE; CELL SELECTION; COXIELLA BURNETII; DIABETES MELLITUS; HOMEOSTASIS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LYMPHOCYTE; MOLECULAR EVOLUTION; MUTAGENESIS; NONHUMAN; OAK; PATHOGENESIS; PHENOTYPE; REVIEW; SOMATIC MUTATION; TISSUE INJURY;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CLONAL DELETION; DIABETES MELLITUS, TYPE 1; EPITOPE MAPPING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GLUTAMATE DECARBOXYLASE; HOMEOSTASIS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; IMMUNITY, NATURAL; MICE; PEPTIDE FRAGMENTS;

EID: 37849040942     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/sj.icb.7100135     Document Type: Review

References (48)

1. Burnet FM. A modification of Jerne's theory of antibody production using the concept of clonal selection. Aust J Sci 1957; 20: 67-69.
2. The Walter and Eliza Hall Institute of Medical Research. Annual Review 1978-79. A Lifetime of Creativity. Burnet at Eighty 1979, pp 6-80.
3. Burnet FM, Fenner F. The Production of Antibodies, 2nd edn. Monograph of the Walter and Eliza Hall Institute of Research in Pathology and Medicine. Macmillan: Melbourne, 1949.
4. Jerne NK. The natural selection theory of antibody formation. Proc Nat Acad Sci (USA) 1955; 41: 849-857.
5. Jerne NK. The complete solution of immunology. Aust Ann Med 1969; 18: 345-348.
6. Burnet FM. Autoimmune disease. Med J Aust 1962; 1: 1-6.
7. Burnet FM. Biological Aspects of Infectious Diseases. Cambridge University Press: London, 1940, pp 29.
8. Burnet FM. The theories of antibody production. In: Najjar VA (ed). Immunity and Virus Infection. Wiley: New York, 1959, pp 1-17.
9. Podulsky SH, Tauber AI. The Generation of Diversity: Clonal Selection Theory and the Rise of Molecular Immunology. Harvard University Press: Cambridge MA, 1997, pp 19-57.
10. Burnet FM. The Clonal Selection Theory of Acquired Immunity. Cambridge University Press: London, 1959.
11. Burnet FM. The basis of allergic disease. Med J Aust 1948; 1: 57-63.
12. Mackay IR, Gajdusek DC. An autoimmune reaction against human tissue antigens in certain acute and chronic diseases. II. Clinical correlations. Arch Intern Med 1958; 101: 30-46.
13. Cowling DC, Mackay IR, Taft LI. Lupoid hepatitis. Lancet 1956; 271: 1323-1326.
14. Mackay IR, Burnet FM. Autoimmune Disease: Pathogenesis, Chemistry and Therapy. Charles C Thomas: Springfield IL, 1963.
15. Dameshek W, Witebsky E, Milgram F. Autoimmunity - Experimental and clinical aspects. Ann NY Acad Sci 1965; 124: 1-978.
16. Burnet FM. Autoimmunity and Autoimmune Disease. Medical and Technical Publishing Co. Ltd: Lancaster, UK, 1972.
17. Burch PR, Rowell NR. Systemic lupus erythematosus: etiological aspects. Am J Med 1965; 38: 793-801.
18. Burch PR. Dupuytren's contracture: an auto-immune disease? J Bone Joint Surg Br 1966; 48: 312-319.
19. Burch PR. An Enquiry Concerning Growth, Disease and Ageing. Oliver and Boyd: Edinburgh UK, 1968.
20. Rose NR, Mackay IR. The Autoimmune Diseases. Academic Press: Orlando, FL, 1985.
21. Rose NR, Mackay IR. The Autoimmune Diseases, 4th edn. Elsevier Science: San Diego, CA, 2006.
22. Rose NR, Bona C. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 1993; 14: 426-430.
23. Scadding JG. Essentialism and nominalism in medicine: logic of diagnosis in disease terminology. Lancet 1996; 348: 594-596.
24. Mackay IR. Hepatic disease and systemic lupus erythematosus. Coincidence or convergence. In: Lahita RG (ed). Systemic Lupus Erythematosus. Elsevier Science: San Diego, CA, 2004, pp 993-1017.
25. Yan ZQ, Hansson GK. Innate immunity, macrophage activation, and atherosclerosis. Immunol Rev 2007; 219: 187-203.
26. Lalor PF, Faint J, Aarbodem Y, Hubscher SG, Adams DH. The role of cytokines and chemokines in the development of steatohepatitis. Semin Liver Dis 2007; 27: 173-193.
27. Paulson JC. Innate immune response triggers lupus-like autoimmune disease. Cell 2007; 130: 589-591.
28. Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997; 84: 223-243.
29. Eaton WW, Rose NR, Kalaydjian A, Pedersen MG, Mortensen PB. Epidemiology of autoimmune diseases in Denmark. J Autoimmun 2007; 29: 1-9.
30. Mackay IR. The etiopathogenesis of autoimmunity. Semin Liver Dis 2005; 25: 239-250.
31. Rose NR, Mackay IR. Molecular mimicry: a critical look at exemplary instances in human diseases. Cell Mol Life Sci 2000; 57: 542-551.
32. Medawar PB. Immunological tolerance. Science 1961; 133: 303-306.
33. Goodnow CC. Multistep pathogenesis of autoimmune disease. Cell 2007; 130: 25-35.
34. Di Lorenzo TP, Peakman M, Roep BO. Translational mini-review series on type 1 diabetes: systematic analysis of T-cell epitopes in autoimmune diabetes. Clin Exp Immunol 2007; 148: 1-16.
35. Gershwin ME, Mackay IR. The causes of primary biliary cirrhosis: Convenient and inconvenient truths. Hepatology 2007; in press.
36. Groom JR, Fletcher CA, Walters SN, Grey ST, Watt SV, Sweet MJ et al. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med 2007; 204: 1959-1971.
37. Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ et al. GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol 2007; 14: 280-286.
38. Fenalti G, Hampe CS, Arafat Y, Law RHP, Banga JP, Mackay IR et al. Clustering of autoantibody and T cell determinants on the structure of the 65kDa isoform of glutarmic acid decarboxylase (GAD65) gives an insight into the molecular basis of autoreactivity. 2007; submitted.
39. Plotz PH. The autoantibody repertoire: searching for order. Nat Rev Immunol 2003; 3: 73-78.
40. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G et al. Association of the T-cell regulatory gene CTLA-4 with susceptibility to autoimmune disease. Nature 2003; 423: 506-511.
41. Lee YH, Rho PA, Choi SJ, Song GG, Nath SK, Harley JB. The PTPN22 C1858T polymorphism and autoimmune disease - a meta-analysis. Rheumatology 2007; 46: 49-56.
42. Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC et al. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med 2007; 356: 1216-1225.
43. Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007; 357: 851-862.
44. Chistiakov DA, Chistiakov AP. Is FCRL3 a new general autoimmunity gene? Hum Immunol 2007; 68: 375-383.
45. Remmers EF, Plenge RM, Lee AT, Graham RG, Hom G, Behrens TW et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. New Engl J Med 2007; 357: 977-986.
46. Chen M, Huang L, Wang J. Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. Blood 2007; 109: 4360-4367.
47. Gasda LS, Gilchrist KA, Lafferty KL. Autoimmunity in diabetes: caught in the causality trap? Immunol Cell Biol 1995; 73: 549-551.
48. Burnet FM. Intrinsic Mutagenesis: A Genetic Approach to Ageing. Medical and Technical Publishing Co. Limited: Lancaster UK, 1974.