Chemical interplay in the mechanism of partial agonist activation in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

Biochemistry

Volumn 47, Issue 1, 2008, Pages 398-404

  Mankiewicz, Kimberly A ^a   Rambhadran, Anu ^a   Wathen, Lisa ^a   Jayaraman, Vasanthi ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE; LIGANDS; MOLECULAR INTERACTIONS; NEUROLOGY; PROTEINS;

FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); LIGAND-PROTEIN INTERACTIONS;

AMINO ACIDS;

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; GLUTAMIC ACID; IONOTROPIC RECEPTOR; KAINIC ACID; LIGAND; RECEPTOR SUBTYPE; WILLARDIINE;

ARTICLE; CENTRAL NERVOUS SYSTEM; CONFORMATIONAL TRANSITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ALANINE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; CELL LINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PYRIMIDINONES; RECEPTORS, AMPA; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; URACIL;

MAMMALIA;

EID: 37849027018     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702004b     Document Type: Article

References (26)

1. Oswald, R. E. (2004) Ionotropic glutamate receptor recognition and activation, Adv. Protein Chem. 68, 313-349.
2. McFeeters, R. L., and Oswald, R. E. (2004) Emerging structural explanations of ionotropic glutamate receptor function, FASEB J. 18, 428-438.
3. Madden, D. R. (2002) The structure and function of glutamate receptor ion channels, Nat. Rev. Neurosci. 3, 91-101.
4. Palmer, C. L., Cotton, L., and Henley, J. M. (2005) The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptors, Pharmacol. Rev. 57, 253-277.
5. Mankiewicz, K. A., Rambhadran, A., Du, M., Ramanoudjame, G., and Jayaraman, V. (2007) Role of the chemical interactions of the agonist in controlling α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation, Biochemistry 46, 1343-1349.
6. Cheng, Q., and Jayaraman, V. (2004) Chemistry and conformation of the ligand-binding domain of GluR2 subtype of glutamate receptors, J. Biol. Chem. 279, 26346-26350.
7. Cheng, Q., Du, M., Ramanoudjame, G., and Jayaraman, V. (2005) Evolution of glutamate interactions during binding to a glutamate receptor, Nat. Chem. Biol. 1, 329-332.
8. Mankiewicz, K. A., and Jayaraman, V. (2007) Glutamate receptors as seen by light: Spectroscopic studies of structure-function relationships, Braz. J. Med. Biol. Res. 40, 1419-1427.
9. Ramanoudjame, G., Du, M., Mankiewicz, K. A., and Jayaraman, V. (2006) Allosteric mechanism in AMPA receptors: A FRET-based investigation of conformational changes, Proc. Natl. Acad. Sci. U.S.A. 103, 10473-10478.
10. Wong, L. A., Mayer, M. L., Jane, D. E., and Watkins, J. C. (1994) Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons, J. Neurosci. 14, 3881-3897.
11. Patneau, D. K., Mayer, M. L., Jane, D. E., and Watkins, J. C. (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine, J. Neurosci. 12, 595-606.
12. Jin, R., Banke, T. G., Mayer, M. L., Traynelis, S. F., and Gouaux, E. (2003) Structural basis for partial agonist action at ionotropic glutamate receptors, Nat. Neurosci. 6, 803-810.
13. Jin, R., and Gouaux, E. (2003) Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: Studies of 5-substituted willardiines and GluR2 S1S2 in the crystal, Biochemistry 42, 5201-5213.
14. Armstrong, N. A., and Gouaux, E. (2000) Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core, Neuron 28, 165-181.
15. Armstrong, N., Mayer, M., and Gouaux, E. (2003) Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes, Proc. Natl. Acad. Sci. U.S.A. 100, 5736-5741.
16. Armstrong, N., Jasti, J., Beich-Frandsen, M., and Gouaux, E. (2006) Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor, Cell 127, 85-97.
17. Furukawa, H., and Gouaux, E. (2003) Mechanisms of activation, inhibition and specificity: Crystal stmctures of the NMDA receptor NR1 ligand-binding core, EMBO J. 22, 2873-2885.
18. Du, M., Reid, S. A., and Jayaraman, V. (2005) Conformational changes in the ligand-binding domain of a functional ionotropic glutamate receptor, J. Biol. Chem. 280, 8633-6.
19. Jayaraman, V., Keesey, R., and Madden, D. R. (2000) Ligand - protein interactions in the glutamate receptor, Biochemistry 39, 8693-8697.
20. Jayaraman, V. (2004) Spectroscopic and kinetic methods for ligand-protein interactions of glutamate receptor. Methods Enzymol. 380, 170-187.
21. Chen, G.-Q., and Gouaux, E. (1997) Overexpression of a glutamate receptor (GluR2) ligand binding domain in Escherichia coli: Application of a novel protein folding screen, Proc. Natl. Acad. Sci. U.S.A. 94, 13431-13436.
22. Cheng, Q., Thiran, S., Yernool, D., Gouaux, E., and Jayaraman, V. (2002) A vibrational spectroscopic investigation of interactions of agonists with GluR0, a prokaryotic glutamate receptor, Biochemistry 41, 1602-1608.
23. Chapman, D., Jackson, M., and Haris, P. I. (1989) Investigation of membrane-protein structure using Fourier-transform infrared-spectroscopy, Biochem. Soc. Trans. 17, 617-619.
24. Ahmed, A. H., Loh, A. P., Jane, D. E., and Oswald, R. E. (2007) Dynamics of the S1S2 glutamate binding domain of GluR2 measured using 19F NMR spectroscopy, J. Biol. Chem. 282, 12773-12784.
25. McFeeters, R. L., and Oswald, R. E. (2002) Structural mobility of the extracellular ligand-binding core of an ionotropic glutamate receptor. Analysis of NMR relaxation dynamics, Biochemistry 41, 10472-10481.
26. Koshland, D. E., Jr., Nemethy, G., and Filmer, D. (1966) Comparison of experimental binding data and theoretical models in proteins containing subunits, Biochemistry 5, 365-385.