Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder

Journal of Medicinal Chemistry

Volumn 50, Issue 24, 2007, Pages 6265-6273

  Perez Medrano, Arturo ^a   Brune, Michael E ^a   Buckner, Steven A ^a   Coghlan, Michael J ^a   Fey, Thomas A ^a   Gopalakrishnan, Murali ^a   Gregg, Robert J ^a   Kort, Michael E ^a   Scott, Victoria E ^a   Sullivan, James P ^a   Whiteaker, Kristi L ^a   Carroll, William A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO N [2,2 DICHLORO 1 [N' (6 CHLOROPYRIDIN 3 YL) N'' CYANOGUANIDINO]PROPYL]BENZAMIDE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BENZAMIDE DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; DYE; GLIBENCLAMIDE; GUANIDINE DERIVATIVE; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; N [2,2 DICHLORO 1 [N' (6 CHLOROPYRIDIN 3 YL) N'' CYANOGUANIDINO]PROPYL] 3,5 DIMETHOXYBENZAMIDE; NITRILE; POTASSIUM CHANNEL AFFECTING AGENT; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTROSTIMULATION; HYPERPOLARIZATION; IN VITRO STUDY; MEMBRANE POTENTIAL; NONHUMAN; OVERACTIVE BLADDER; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SWINE;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DOGS; ELECTRIC STIMULATION; FEMALE; GUANIDINES; HUMANS; ION CHANNEL GATING; KATP CHANNELS; MUSCLE RELAXATION; MUSCLE, SMOOTH; POTASSIUM CHANNELS, INWARDLY RECTIFYING; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URODYNAMICS;

EID: 37849005391     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7010194     Document Type: Article

References (31)

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