In-silico model of skin penetration based on experimentally determined input parameters. Part I: Experimental determination of partition and diffusion coefficients

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 68, Issue 2, 2008, Pages 352-367

  Hansen, Steffi ^a   Henning, Andreas ^a   Naegel, Arne ^b   Heisig, Michael ^b   Wittum, Gabriel ^b   Neumann, Dirk ^a   Kostka, Karl Heinz ^c   Zbytovska, Jarmila ^d   Lehr, Claus Michael ^a   Schaefer, Ulrich F ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Caritas Hospital   (Germany)

^d Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Caffeine; Diffusion coefficient; Flufenamic acid; Modeling skin penetration; Partition coefficient; Tape stripping

Indexed keywords

CAFFEINE; FLUFENAMIC ACID; SKIN LIPID;

ARTICLE; CONTROLLED STUDY; DERMIS; DIFFUSION COEFFICIENT; DRUG DIFFUSION; DRUG PENETRATION; DRUG TRANSPORT; EPIDERMIS; FEMALE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; MATHEMATICAL MODEL; PARAMETER; PARTITION COEFFICIENT; SKIN ABSORPTION; SKIN CELL; SKIN PENETRATION; STRATUM CORNEUM;

DIFFUSION; FEMALE; FLUFENAMIC ACID; HUMANS; MODELS, BIOLOGICAL; SKIN ABSORPTION;

EID: 37849002776     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.05.012     Document Type: Article

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