Unexpected Clobetasol Propionate Profile in Human Stratum Corneum after Topical Application in Vitro

Pharmaceutical Research

Volumn 20, Issue 11, 2003, Pages 1835-1837

  Mueller, Beat ^a   Anissimov, Yuri G ^a   Roberts, Michael S ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Clobetasol propionate; Drug profile; Maximal flux; Stratum corneum

Indexed keywords

CLOBETASOL;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; EPIDERMIS; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; IN VITRO STUDY; MICRODIALYSIS; PRIORITY JOURNAL; SAMPLING; SKIN; STEADY STATE; STRATUM CORNEUM; VALIDATION PROCESS;

ADMINISTRATION, TOPICAL; ADULT; CLOBETASOL; DIFFUSION CHAMBERS, CULTURE; EPIDERMIS; FEMALE; HUMANS; MIDDLE AGED; PERMEABILITY;

EID: 0345377426     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000003382.20030.54     Document Type: Article

References (12)

1. C. S. Leopold and H. I. Maibach. Effect of lipophilic vehicles on in vivo skin penetration of methyl nicotinate in different races. Int. J. Pharm. 139:161-167 (1996).
2. M. Bach and B. C. Lippold. Percutaneous penetration enhancement and its quantification. Eu. J. Pharm. Biopharm. 46:1-13 (1998).
3. Code of Federal Regulations. US Government Printing Office, Washington DC, 1999.
4. Guidance. Topical Dermatologic Corticosteroids: in Vivo Bioequivalence, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Rockville, MD, USA, 1995.
5. F. Pirot, Y. N. Kalia, A. L. Stinchcomb, G. Keating, A. Bunge, and R. H. Guy. Characterization of the permeability barrier of human skin in vivo. Proc. Natl. Acad. Sci. USA. 94:1562-1567 (1997).
6. G. J. Singh, W. P. Adams, L. J. Lesko, V. P. Shah, J. A. Molzon, R. L. Williams, and L. K. Pershing. Development of in vivo bioequivalence methodology for dermatologic corticosteroids based on pharmacodynamic modeling. Clin. Pharmacol. Ther. 66:346-357 (1999).
7. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall. Protein measurement with the Folin Phenol reagent. J. Biol. Chem. 193:265-275 (1951).
8. F. Dreher, A. Arens, J. J. Hostynek, S. Mudumba, J. Ademola, and H. I. Maibach. Colorimetric method for quantifying human Stratum corneum removed by adhesive-tape stripping. Acta Derm. Venereol. 78:186-189 (1998).
9. H. E. Bodde, M. A. M. Kruithof, J. Brussee, and H. K. Koerten. Visualization of normal and enhanced mercuric chloride transport through human skin in vitro. Int. J. Pharm. 53:13-24 (1989).
10. A. Weerheim and M. Ponec. Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography. Arch. Dermatol. Res. 293:191-199 (2001).
11. M. Simon, D. Bernard, A. M. Minondo, C. Camus, F. Fiat, P. Corcuff, R. Schmidt, and G. Serre. Persistence of both peripheral and non-peripheral corneodesmosomes in the upper stratum corneum of winter xerosis skin versus only peripheral in normal skin. J. Invest. Dermatol. 116:23-30 (2001).
12. B. Querleux, S. Richard, J. Bittoun, O. Jolivet, P. I. Idy, R. Bazin, and J. L. Leveque. In vivo hydration profile in skin layers by high-resolution magnetic resonance imaging. Skin Pharmacol. 7: 210-216 (1994).