High altitude induced anorexia: Effect of changes in leptin and oxidative stress levels

Nutritional Neuroscience

Volumn 10, Issue 5-6, 2007, Pages 243-249

  Vats, Praveen ^a   Singh, Vijay Kumar ^a   Singh, Som Nath ^a   Singh, Shashi Bala ^a  

^a DEFENCE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES   (India)

Author keywords

Anorexia; High altitude; Leptin; N acetyl cysteine; Neuropeptide Y; Vitamin E; Weight loss

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; GLUCONATE CALCIUM; LEPTIN; MALONALDEHYDE; PLACEBO;

ADULT; ALTITUDE DISEASE; ANOREXIA; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; WEIGHT REDUCTION;

ACETYLCYSTEINE; ADULT; ALTITUDE; ANOREXIA; ANTIOXIDANTS; BODY MASS INDEX; ENERGY INTAKE; HUMANS; LEPTIN; MALE; MALONDIALDEHYDE; NEUROPEPTIDE Y; OXIDATIVE STRESS; PLACEBOS; VITAMIN E; WEIGHT LOSS;

EID: 37849001854     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1080/10284150701722299     Document Type: Article

References (57)

1. Bailey, DM and Davies, B. (2001) Acute mountain sickness; Prophylactic benefits of antioxidant vitamin supplementation at high altitude. High Alt Med Biol, 2, pp. 21-29.
2. Bailey, DM, Davies, B., Milledge, JS, Richards, M., Williams, SRP, Jordinson, M. and Calam, J. (2000) Elevated plasma cholecystokinin at high altitude: Metabolic implications for the anorexia of acute mountain sickness. High Alt Med Biol, 1, pp. 9-23.
3. Bailey, DM, Ainslie, PN, Jackson, SK, Richardson, RS and Ghatei, M. (2004) Evidence against redox regulation of energy homoeostasis in human at high altitude. Clin Sci (Lond), 107, pp. 589-600.
4. Balasubramaniyan, V., Sailaja, J Kalaivani and Nalini, N. (2003) Role of leptin on alcohol-induced oxidative stress in Swiss mice. Pharmacol Res, 47, pp. 211-216.
5. Beltowski, J., Wojcicka, G., Marciniak, A. and Jamroz, A. (2004) Oxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension. Life Sci, 74, pp. 2987-3000.
6. Boyer, SJ and Blume, FD (1984) Weight loss and changes in body composition at high altitude. J Appl Physiol, 57, pp. 1580-1585.
7. Brahmachari, HD, Malhotra, MS, Ramachandran, K. and Radhakrishnan, U. (1973) Progressive changes in plasma cortisol, antidiuretic hormone and urinary volume of normal lowlanders during short stay at altitude. Indian J Exp Biol, 11, pp. 454-455.
8. Butterfield, GE (1996) Maintenance of body weight at altitude: In search of 500 kcal/day. Nutritional needs in cold and in high altitude environments, pp. 357-378. National Academy Press, Washington DC
9. Butterfield, GE, Gates, J., Fleming, S., Brooks, GA, Sutton, JR and Reeves, JT (1992) Increased energy intake minimizes weight loss in men at high altitude. J Appl Physiol, 72, pp. 1741-1748.
10. de Leon, A Cabrera, Gonzalez, DA, Mendez, LI Perez, Aguirre-Jaime, A., Perez, M del Cristo Rodriguez, Coello, SD and Trujillo, IC (2004) Leptin and altitude in the cardiovascular diseases. Obes Res, 12, pp. 1492-1498.
11. Chang, JL and Mantzoros, CS (2005) Role of leptin in energy-deprivation state: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet, 366, pp. 74-85.
12. Frankish, HM, Dryden, S., Hopkins, D., Wang, Q. and Williams, G. (1995) Neuropeptide Y, the hypothalamus, and diabetes: Insights into the central control of metabolism. Peptides, 16, pp. 757-771.
13. Frederich, RC, Lollmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, BB, Lowell, BB and Flier, JS (1995) Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest, 96, pp. 1658-1663.
14. Guilland, JC and Klepping, J. (1985) Nutritional alterations at high altitude in man. Eur J Appl Physiol Occup Physiol, 54, pp. 517-523.
15. Halaas, JL, Gajiwala, KS, Maffei, M., Cohen, SL, Chait, BT, Rabinowitz, D., Lallone, RL, Burley, SK and Friedman, JM (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 269, pp. 543-546.
16. Hansen, MJ, Jovanovska, V. and Morris, MJ (2004) Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J Neurochem, 88, pp. 909-916.
17. Hance, AJ, Robin, ED, Simon, LM, Alexander, S., Herzenberg, LA and Theodore, J. (1980) Regulation of glycolytic enzyme activity during chronic hypoxia by changes in rate-limiting enzyme content. Use of monoclonal antibodies to quantitate changes in pyruvate kinase content. J Clin Invest, 66, pp. 1258-1264.
18. Hardie, LJ, Rayner, DV, Holmes, S. and Trayhurn, P. (1996) Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun, 223, pp. 660-665.
19. Heinrichs, SC, Menzaghi, F. and Koob, GF (1998) Neuropeptide Y-induced feeding and its control. Vitam Horm, 54, pp. 51-66.
20. Heymsfield, SB, Greenberg, AS, Fujioka, K., Dixon, RM, Kushner, R., Hunt, T., Lubina, JA, Patane, J., Self, B., Hunt, P. and McCamish, M. (1999) Recombinant leptin for weight loss in obese and lean adults. JAMA, 282, pp. 1568-1575.
21. Ilavazhagan, G., Bansal, A., Prasad, D., Thomas, P., Sharma, SK, Kain, AK, Kumar, D. and Selvamurthy, W. (2001) Effect of vitamin E supplementation on hypoxia-induced oxidative damage in male albino rats. Aviat Space Environ Med, 72, pp. 899-903.
22. Jain, SC, Bardhan, J., Swamy, Y., Krishna, B. and Nayar, H. (1980) Body fluid compartments in humans during acute high-altitude exposure. Aviat Space Environ Med, 51, pp. 234-236.
23. Jefferson, JA, Simoni, J., Escudero, E., Hurtado, ME, Swenson, ER, Wesson, DE, Schreiner, GF, Schoene, RB, Johnson, RJ and Hurtado, A. (2004) Increased oxidative stress following acute and chronic high altitude exposure. High Alt Med Biol, 5, pp. 61-69.
24. Joanny, P., Steinberg, J., Robach, P., Richalet, JP, Gortan, C., Gardette, B. and Jammes, Y. (2001) Operation Everest III (Comex'97): The effect of simulated severe hypobaric hypoxia on lipid peroxidation and antioxidant defence systems in human blood at rest and after maximal exercise. Resuscitation, 49, pp. 307-314.
25. Kalra, SP (1997) Appetite and body weight regulation: Is it all in the brain?. Neuron, 19, pp. 227-230.
26. Kayser, B., Acheson, K., Decombaz, J., Fern, E. and Cerretelli, P. (1992) Protein absorption and energy digestibility at high altitude. J Appl Physiol, 73, pp. 2425-2431.
27. Kayser, B., Narici, M., Binzoni, T., Grassi, B. and Cerretelli, P. (1994) Fatigue and exhaustion in chronic hypobaric hypoxia: Influence of exercising muscle mass. J Appl Physiol, 76, pp. 634-640.
28. Lee, GH, Proenca, R., Montez, JM, Carroll, KM, Darvishzadeh, JG, Lee, JI and Friedman, JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379, pp. 632-635.
29. MacDougald, OA, Hwang, CS, Fan, H. and Lane, MD (1995) Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA, 92, pp. 9034-9037.
30. Maffei, M., Halaas, J., Ravussin, E., Pratley, RE, Lee, GH, Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., Kern, PA and Friedman, JM (1995) Leptin levels in human and rodents: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med l, pp. 1155-1161.
31. Magalhaes, J., Ascensao, A., Viscor, G., Scares, J., Oliveira, J., Marques, F. and Duarte, J. (2004) Oxidative stress in humans during and after 4 hours of hypoxia at a simulated altitude of 5500 m. Aviat Space Environ Med, 75, pp. 16-22.
32. Norese, MF, Lezon, CE, Alippi, RM, Martinez, MP, Conti, MI and Bozzini, CE (2002) Failure of polycythemia-induced increase in arterial oxygen content to suppress the anorexic effect of simulated high altitude in the adult rat. High Alt Med Biol, 3, pp. 49-57.
33. Pelleymounter, MA, Cullen, MJ, Baker, MB, Hecht, R., Winters, D., Boone, T. and Collins, F. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269, pp. 540-543.
34. Plata-Salaman, CR (1998) Cytokines and feeding. News Physiol Sci, 13, pp. 298-304.
35. Radak, Z., Lee, K., Choi, W., Sunoo, S., Kizaki, T., Oh-ishi, S., Suzuki, K., Taniguchi, N., Ohno, H. and Asano, K. (1994) Oxidative stress induced by intermittent exposure at a simulated altitude of 4000 m decreases mitochondrial superoxide dismutase content in soleus muscle of rats. Eur J Appl Physiol Occup Physiol, 69, pp. 392-395.
36. Raposinho, P., Pierroz, DD, Broqua, P., White, RB, Pedrazzini, T. and Aubert, ML (2001) Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism. Mol Cell Endocrinol, 185, pp. 195-204.
37. Rose, MS, Houston, CS, Fulco, CS, Coates, G., Sutton, JR and Cymerman, A. (1988) Operation Everest II: Nutrition and body composition. J Appl Physiol, 65, pp. 2545-2551.
38. Sawhney, RC, Malhotra, AS, Singh, T., Rai, RM and Sinha, KC (1986) Insulin secretion at high altitude in man. Int J Biometeorol, 30, pp. 231-238.
39. Sawhney, RC, Malhotra, AS and Singh, T. (1991) Glucoregulatory hormones in man at high altitude. Eur J Appl Physiol Occup Physiol, 62, pp. 286-291.
40. Schmidt, MC, Askew, EW, Roberts, DE, Prior, RL, Ensign Jr, WY and Hesslink, RE (2002) Oxidative stress in humans training in a cold, moderate altitude environment and their response to a phytochemical antioxidant supplement. Wilderness Environ Med, 13, pp. 94-105.
41. Singh, M., Rawal, S. and Tyagi, A. (1990) Body fluid status on induction, reinduction and prolonged stay at high altitude of human volunteers. Int J Biometeorol, 34, pp. 93-97.
42. Singh, SB, Sharma, A., Sharma, KN and Selvamurthy, W. (1996) Effect of high-altitude hypoxia on feeding responses and hedonic matrix in rats. J Appl Physiol, 80, pp. 1133-1137.
43. Srivastava, KK, Kumria, MML, Graver, SK, Sridharan, K. and Malhotra, MS (1975) Glucose tolerance of lowlanders during prolonged stay at high altitude and among high altitude natives. Aviat Space Environ Med, 46, pp. 144-146.
44. Tartaglia, LA, Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, GJ, Campfield, LA, Clark, FT, Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, KJ, Smutko, JS, Mays, GG, Wool, EA, Monroe, CA and Tepper, RI (1995) Identification and expression cloning of a leptin receptor OB-R. Cell, 83, pp. 1263-1271.
45. Trayhurn, P., Duncan, JS and Rayner, DV (1995) Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system. Biochem J, 311, pp. 729-733.
46. Tschop, M., Strasburger, CJ, Hartmann, G., Biollaz, J. and Bartsch, P. (1998) Raised leptin concentrations at high altitude associated with loss of appetite. Lancet, 352, pp. 1119-1120.
47. Utley, HG, Bernheim, F. and Hochstein, P. (1967) Effect of sulfhydryl reagents on peroxidation of microsomes. Arch Biochem Biophy, 118, pp. 29-32.
48. Vats, P., Mukherjee, AK, Kumria, MML, Singh, SN, Patil, SKB, Ranganathan, S. and Sridharan, K. (1999) Changes in the activity levels of glutamine synthetase, glutaminase and glycogen synthetase in rat subjected to hypoxic stress. Int J Biometeorol, 42, pp. 205-209.
49. Vats, P., Singh, SN, Shyam, R., Singh, VK, Singh, SB, Banerjee, PK and Selwamurthy, W. (2004) Leptin may not be responsible for high altitude anorexia. High Alt Med Biol, 5, pp. 90-92.
50. Vettor, R., Zarjevski, N., Cusin, I., Rohner-Jeanrenaud and Jeanrenaud, B. (1994) Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia, 37, pp. 1202-1208.
51. Westerterp, KR, Kayser, B., Brouns, F., Herry, JP and Saris, WH (1992) Energy expenditure climbing Mt. Everest. J Appl Physiol, 73, pp. 1815-1819.
52. Westerterp-Plantenga, MS (1999) Effects of extreme environments on food intake in human subjects. Proc Nutr Soc, 58, pp. 791-798.
53. Westerterp-Plantenga, MS, Westerterp, KR, Rubbens, M., Verwegen, CR, Richelet, JP and Gardette, B. (1999) Appetite at "high altitude" [Operation Everest III (Comex-'97)]: A simulated ascent to Mount Everest. J Appl Physiol, 87, pp. 391-399.
54. Woods, SC, Seeley, RJ, Porte Jr., D. and Schwartz, MW (1998) Signals that regulate food intake and energy homeostasis. Science, 280, pp. 1378-1383.
55. Woolcott, OO, Castillo, OA, Torres, J., Damas, L. and Florentini, E. (2002) Serum leptin levels in dwellers from high altitude lands. High Alt Med Biol, 3, pp. 245-246.
56. Zaccaria, M., Ermolao, A., Bonvicini, P., Travain, G. and Varnier, M. (2004) Decreased serum leptin levels during prolonged high altitude exposure. Eur J Appl Physiol, 92, pp. 249-253.
57. Zachariah, T., Rawal, SB, Pramanik, SN, Singh, MV, Kishnani, S., Bhardwaj, H. and Rai, RM (1987) Variation in skinfold thickness during de-acclimatization and re-acclimatization to high altitude: Relation to body fat content. Eur J Appl Physiol Occup Physiol, 56, pp. 570-576.