Methotrexate inhibits integrin adhesion molecules in the mouse model of pleurisy induced by carrageenan

Brazilian Archives of Biology and Technology

Volumn 50, Issue 5, 2007, Pages 777-784

  Dalmarco, Eduardo Monguilhott ^a   Fröde, Tânia Silvia ^b  

^a REGIONAL UNIVERSITY OF BLUMENAU   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

CD11a CD18 adhesion molecules; Leukocyte migration; Methotrexate; Mice; Pleurisy

Indexed keywords

MUS;

EID: 37749044179     PISSN: 15168913     EISSN: 15168913     Source Type: Journal    
DOI: 10.1590/S1516-89132007000500005     Document Type: Article

References (38)

1. Budzik, G. P.; Colletti, L.M.; Faltynek, C. R. (2000), Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line. Life Sci., 66, 2297-2307.
2. Chao, N. J., Schmidt, G. M., Niland, J. C., Amylon, M. D., Dagis, A. C., Long, G. D., Nademanee, A. P., Negrin, R. S., O'Donnell, M. R., Parker, P. M., Smith, E. P., Snyder, D. S., Stein, A. S., Wong, R. M., Blume, K. G. and Forman, S. J. (1993), Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-vs.-host disease. N. Engl. J. Med., 329, 1225-1230.
3. Ciesielski, C. J., Mei, J.; Piccinini, L. A. (1998), Effects of cyclosporine A and methotrexate on CD 18 expression in recipients of rat cardiac allografts. Transpl Immunol., 6, 122-33.
4. Constantin, A.; Loubet-Lescoulie, P.; Lambert, N.; Yassine-Diab, B.; Abbal, M.; Mazieres, B.;De Preval, C.; Cantagrel, A. (1998), Antiinflammatory and immunoregulatoryaction of methotrexate in the treatment of rheumatoid arthritis: evidence ofincreased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain reaction. Arthritis Rheum., 41, 48-57.
5. Dahlman-Ghozlan, K.; Heilborn, J. D.; Stephansson, E. (2000), Circulating levels of soluble E-selectin, ICAM-1 and VCAM-1 in bullous pemphigoid during low-dose methotrexate therapy. A prospective study. Exp Dermatol., 9, 336-340.
6. Dalmarco, E. M.; Frode, T. S.; Medeiros, Y. S. (2002), Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy. Mediators Inflamm., 11, 299-306.
7. Dervieux, T.; Brenner, T. L.; Hon, Y. Y.; Zhou, Y.; Hancock, M. L.; Sandlund, J. T.; Rivera, G. K.; Ribeiro, R. C.; Boyett, J. M.; Pui, C. H.; Relling, M. V.; Evans, W. E. (2002), De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo. Blood., 100, 1240-1247.
8. Fairbanks, L. D.; Ruckemann, K.; Qiu, Y.; Hawrylowicz, C. M.; Richards, D. F.; Swaminathan, R.; Kirschbaum, B.; Simmonds H. A. (1999), Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis? Biochem J., 342, 143-152.
9. Farber, S., Toch, R., Sears, E. and Pinkel, D., 1956. Advances in chemotherapy of cancer in man. In: Advances in Cancer Research, Greenstein, H.A., Editor, 1956., Academic Press, New York, pp. 2-73.
10. Genestier, L.; Paillot, R.; Quemeneur, L.; Izeradjene, K.; Revillard, J. P. (2000), Mechanisms of action of methotrexate. Immunopharmacology, 47, 247-257.
11. Kraan, M. C.; De Koster, B. M.; Elferink, J. G.; Post, W. J.; Breedveld, F. C.; Tak, P. P. (2000), Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. Arthritis Rheum., 43, 1488-1495.
12. Losses, I. S.; Izbicki, G.; Or, R.; Goldstein, R. H.; Breuer, R. (2000), The effects of suramin on bleomycin-induced lung injury. Life Science., 67, 2873-2881.
13. Markovic, S.; Raab, M.; Daxecker, H.; Griesmacher, A.; Karimi, A.; Muller, M. M. (2002) In vitro effects of cyclosporin A on the expression of adhesion molecules on human umbilical vein endothelial cells. Clin Chim Acta., 316, 25-31.
14. Montesinos, M. C.; Yap, J. S.; Desai, A.; Posadas, I.; Mccrary, C. T.; Cronstein, B. N. (2002), Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. Arthritis Rheum., 43, 656-663.
15. Morabito, L.; Montesinos, M. C.; Schreibman, D. M.; Balter, L.; Thompson, L. F.; Resta, R.; Carlin, G.; Huie, M. A.; Cronstein, B. N. Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5′-nucleotidase -mediated conversion of adenine nucleotides. J Clin Invest., 101: 295-300, 1998.
16. Motohiro, A.; Furukawa, K.; Yasumoto, K.; Inokuchi, K. (1986), Mechanisms involved in acute lung edema induced in dogs by oleic acid. Eur Surg Res., 18, 50-57.
17. Nash, R. A., Pepe, M. S., Storb, R., Longton, G., Pettinger, M., Anasetti, C., Appelbaum, F. R., Bowden, R. A., Deeg, H. J., Doney, K., Martin, P. J., Sullivan, K. M., Sanders, J., Witherspoon, R. P. (1992), Acute graft-vs.-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate. Blood, 80, 1838-1845.
18. Nash, R. A.; Pineiro, L. A.; Storb, R.; Deeg, H. J.; Fitzsimmons, W. E.; Furlong, T.; Hansen, J.A.; Gooley, T.; Maher, R. M.; Martin, P.; McSweeney, P. A.; Sullivan, K. M.; Anasetti, C.; Fay, J. W. (1996), FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors. Blood. 88, 3634-3641.
19. O'callaghan, J. W.; Forrest, M. J.; Brooks, P. M. (1988), Inhibition of neutrophil chemotaxis in methotrexate-treated rheumatoid arthritis patients. Rheumatol Int., 8, 41-45.
20. Oliver, S. J.; Cheng, T. P.; Banquerigo, M. L.; Brahn, E. (1995), Suppression of collagen-induced arthritis by an angiogenesis inhibitor, AGM-1470, in combination with cyclosporin: reduction of vascular endothelial growth factor (VEGF). Cell Immunol., 166, 196-206.
21. Olsen, S. L., O'Connell, J. B., Bristow, M. R., Renlund, D.G. (1990), Methotrexate as an adjunct in the treatment of persistent mild cardiac allograft rejection. Transplantation, 50, 773-775.
22. Panetta, J. C.; Yanishevski, Y.; Pui, C. H.; Sandlund, J. T.; Rubnitz, J.; Rivera, G. K.; Ribeiro, R.; Evans, W. E.; Relling, M. V.(2002), A mathematical model of in vivo methotrexate ccumulation in acute lymphoblastic leukemia. Cancer Chemother Pharmacol., 50, 419-428.
23. Rafiee, P.; Johnson, C. P.; Li, M. S.; Ogawa, H.; Heidemann, J.; Fisher, P. J.; Lamirand, T. H.; Otterson, M. F.; Wilson, K. T.; Binion, D. G. (2002), Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. J Biol Chem., 277, 35605-35615.
24. Saleh, T. S. F.; Calixto, J. B.; Medeiros, Y. S. (1996), Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy. Br. J. Pharmacol., 118, 811-819.
25. Schnabel, A. (2001), Methotrexate: Mechanisms of action, pharmacology and toxicology. In: Immunosuppression in inflammatory bowel diseases standards, new developments, future trends. Dordrecht, Germany, pp. 113-118.
26. Seitz, M., (1999), Molecular and cellular effects of methotrexate. Curr Opin Rheumatol., 11, 226-232, 1999.
27. Seitz, M.; Dayer, J.M. (2000), Enhanced production of tissue inhibitor of metalloproteinases by peripheral blood mononuclear cells of rheumatoid arthritis patients responding to methotrexate treatment. Rheumatology, 39, 637-645.
28. Servitje, O., Bordas, X., Seron, D., Vidaller, A., Moreno, A., Curco, N., Sais, G., Peyri, J., (1996), Changes in T-cell phenotype and adhesion molecules expression in psoriatic lesions after low-dose cyclosporin therapy. J Cutan Pathol., 23: 431-436.
29. Storb, R., Deeg, H. J., Whitehead, J., Appelbaum, F., Beatty, P., Bensinger, W., Buckner, D., Clift, R., Doney, K., Farewell, V., Hansen, J., Hill, R., Lum, L., Martin, P., McGuffin, R., Sanders, J., Stewart, P., Sullivan, K., Witherspoon, R., Yee, G., Thomas, E.D., (1986), Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft-vs.-host disease after marrow transplantation for leukemia. N. Engl. J. Med., 314, 729-735.
30. Sullivan, K. M., Storb, R., Buckner, D., Ferer, A., Fisher, L., Weiden, P. L., Witherspoon, R. P., Appelbaum, F. R., Banaji, M., Hansen, J., Martin, P., Sanders, J. E., Singer, J., Thomas, D. (1989), Graft-versus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms. N. Engl. J. Med., 320, 828-834.
31. Sung, J. Y.; Hong, J. H.; Kang, H. S.; Choi, I.; Lim, S. D.; Lee, J. K.; Seok, J. H.; Lee, J H.; Hur, G. M. (2000), Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. Immunopharmacology., 47, 35-44.
32. Wakabayashi, T.; Jackson, K.; Yamada, C.; Suzuki, Y.; Suzuki, Y. (2003), [Inhibition of joint destruction by Methotrexate.] Clin Calcium. 13: 764-770.
33. Wang, Q.;Teder, P.; Judd, N. P.; Noble, P. W.; Doerschuk, C. M. (2002), Cd44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. Am J Pathol., 161, 2219-2228.
34. Weinblatt, M. E.; Maier, A. L.; Fraser, P. A.; Coblyn, J. S. (1998), Long-term prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy. J Rheumatol., 25, 238-242.
35. White, J. C. (1981), Recent concepts on the mechanism of action of methotrexate. Cancer Treat. Rep. 65, 3-12.
36. Winkelstein, A. (1975), Effects of cytotoxic immunosuppressants on tuberculin-sensitive lymphocytes in guinea pigs. J Clin Invest., 56, 1587-1596.
37. Yamasaki, E., Soma, Y., Kawa, Y., Mizoguchi, M. (2003), Methotrexate inhibits proliferation and regulation of the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by cultured human umbilical vein endothelial cells. Br J Dermatol., 149: 30-38.
38. Zhou, S. G, Xu L. P., Liao, D. F., Lei, X. Y., Yan, F. X., Zhu, B. Y. (2004), [Cyclosporin A inhibits the adhesion of neutrophil with ECV-304 induced by hypoxia/ reoxygenation via ROS-Cyclophilin A-ERK1/2 pathway] Sheng Li Xue Bao., 56: 313-320.