The nose may help the brain: Intranasal drug delivery for treating neurological diseases

Future Neurology

Volumn 3, Issue 1, 2008, Pages 1-4

  Ying, Weihai ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; BETA INTERFERON; DRUG CARRIER; ERYTHROPOIETIN; FIBROBLAST GROWTH FACTOR 2; GLYCOSIDASE INHIBITOR; INSULIN; LEPTIN; MACROGOL; NANOPARTICLE; NERVE GROWTH FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; NOBOTANIN B; OXYTOCIN; POLYLACTIC ACID; SOMATOMEDIN C; TANNIN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ HORSERADISH PEROXIDASE;

ALZHEIMER DISEASE; AMNESIA; ANTIOXIDANT ACTIVITY; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG TRANSPORT; EDITORIAL; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; NOSE; OLFACTORY BULB; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; TRIGEMINAL NERVE;

EID: 37649010510     PISSN: 14796708     EISSN: None     Source Type: Journal    
DOI: 10.2217/14796708.3.1.1     Document Type: Editorial

References (20)

1. Pardridge WM: The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2, 3-14 (2005).
2. Ilum L: Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 11, 1-18 (2000).
3. Thorne RG, Emory CR, Ala TA, Frey WH 2nd: Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res. 692, 278-282 (1995).
4. Ma YP, Ma MM, Ge S et al.: Intranasally delivered TGF-β1 enters brain and regulates gene expressions of its receptors in rats. Brain Res. Bull. 74, 271-277 (2007).
5. Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd: Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127, 481-496 (2004).
6. Reger MA, Watson GS, Frey WH 2nd et al.: Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol. Aging 27, 451-458 (2006).
7. Pulliam L, Sun B, Rempel H et al.: Intranasal Tat alters gene expression in the mouse brain. J. Neuroimmune Pharmacol. 2, 87-92 (2007).
8. Yu YP, Xu QQ, Zhang Q et al.: Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia. Neurosci. Lett. 387, 5-10 (2005).
9. Jin K, Yie L, Childs J et al.: Cerebral neurogenesis is induced by intranasal administration of growth factors. Ann. Neurol. 53, 405-409 (2003).
10. De Rosa R, Garcia AA, Braschi C et al.: Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc. Natl Acad. Sci. USA 102, 3811-3816 (2005).
11. Liu XF, Fawcett JR, Thorne RG, Frey WH 2nd: Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion. Neurosci. Lett. 308, 91-94 (2001).
12. Ying W, Sevigny MB, Chen Y, Swanson RA: Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proc. Natl Acad. Sci USA 98, 12227-12232 (2001).
13. Wei G, Wang D, Lu H et al.: Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury. Front. Biosci. 12, 4986-4996 (2007).
14. + repletion prevents PARP-1- induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem. Biophys. Res. Commun. 308, 809-813 (2003).
15. + profoundly decreases brain injury in a rat model of transient focal ischemia. Front. Biosci. 12, 2728-2734 (2007).
16. + for treating neurological diseases. Future Neurol. 2, 129-132 (2007).
17. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E: Oxytocin increases trust in humans. Nature 435, 673-676 (2005).
18. Benedict C, Hallschmid M, Schultes B, Born J, Kern W: Intranasal insulin to improve memory function in humans. Neuroendocrinology 86, 136-142 (2007).
19. Dhanda D, Frey WH 2nd, Leopold D, Kompella UB: Nose-to-brain delivery: approaches for drug deposition in the human olfactory epithelium. Drug Delivery Technol. 5(4), 64-72 (2005).
20. Zhang QZ, Zha LS, Zhang Y et al.: The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in rats. J. Drug Target 14, 281-290 (2006).