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37649010763
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Chapleo, C. B.; Myers, P. L. Eur. Pat. Appl. EP 0071368, 1983.
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2
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0021326394
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Chapleo C.B., Myers P.L., Butler R.C.M., Davis J.A., Doxey J.C., Higgins S.D., Myers M., Roach A.G., Smith C.F.C., Stillings M.R., and Welbourn A.P. J. Med. Chem. 27 (1984) 570
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Chapleo, C.B.1
Myers, P.L.2
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Doxey, J.C.5
Higgins, S.D.6
Myers, M.7
Roach, A.G.8
Smith, C.F.C.9
Stillings, M.R.10
Welbourn, A.P.11
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5
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0344289189
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For the determination of the absolute stereochemistry of (R)-(+)-efaroxan, see:
-
For the determination of the absolute stereochemistry of (R)-(+)-efaroxan, see:. Belin C., Chauvet A., Leloup J.M., Ribet J.P., and Maurel J.L. Acta Crystallogr., Sect. C 51 (1995) 2439
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Acta Crystallogr., Sect. C
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Belin, C.1
Chauvet, A.2
Leloup, J.M.3
Ribet, J.P.4
Maurel, J.L.5
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6
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37649018468
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Chapleo, C. B.; Doxey, J. C.; Stillings, M. R. PCT Int. Appl. WO 92/05171, 1992.
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7
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2342667989
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2-adrenoceptor antagonists, see:
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2-adrenoceptor antagonists, see:. Mayer P., and Imbert T. IDrugs 4 (2001) 662
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(2001)
IDrugs
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Mayer, P.1
Imbert, T.2
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8
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37649024545
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Colpaert, F.; Briley, M.; Imbert, T. PCT Int. Appl. WO 95/00145, 1995.
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9
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37648999263
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Colpaert, F.; Briley, M.; Imbert, T. PCT Int. Appl. WO 95/01791, 1995.
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10
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0028987304
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For a study on the effect of (+)-efaroxan on acetylcholine release in the rat cortex, see:
-
For a study on the effect of (+)-efaroxan on acetylcholine release in the rat cortex, see:. Tellez S., Colpaert F., and Marien M. Eur. J. Pharmacol. 277 (1995) 113
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(1995)
Eur. J. Pharmacol.
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Tellez, S.1
Colpaert, F.2
Marien, M.3
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12
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0031692835
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Eglen R.M., Hudson A.L., Kendall D.A., Nutt D.J., Morgan N.G., Wilson V.G., and Dillon M.P. Trends Pharmacol. Sci. 19 (1998) 381
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(1998)
Trends Pharmacol. Sci.
, vol.19
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Eglen, R.M.1
Hudson, A.L.2
Kendall, D.A.3
Nutt, D.J.4
Morgan, N.G.5
Wilson, V.G.6
Dillon, M.P.7
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14
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37649025313
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See Ref. 3a.
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15
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0032799426
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3 receptor:
-
3 receptor:. Morgan N.G., Chan S.L.F., Mourtada M., Monks L., and Ramsden C.A. Ann. NY Acad. Sci. 881 (1999) 217
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(1999)
Ann. NY Acad. Sci.
, vol.881
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Morgan, N.G.1
Chan, S.L.F.2
Mourtada, M.3
Monks, L.4
Ramsden, C.A.5
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18
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0031713515
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-
The interest of 5-amino efaroxan derivative for the isolation of imidazoline binding proteins was outlined in the literature:
-
The interest of 5-amino efaroxan derivative for the isolation of imidazoline binding proteins was outlined in the literature:. Chan S.L.F., Pallett A.L., Clews J., Ramsden C.A., Chapman J.C., Kane C., Dunne M.J., and Morgan N.G. Eur. J. Pharmacol. 355 (1998) 67
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(1998)
Eur. J. Pharmacol.
, vol.355
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Chan, S.L.F.1
Pallett, A.L.2
Clews, J.3
Ramsden, C.A.4
Chapman, J.C.5
Kane, C.6
Dunne, M.J.7
Morgan, N.G.8
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19
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0032973340
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Monks L.K., Cosgrove K.E., Dunne M.J., Ramsden C.A., Morgan N.G., and Chan S.L.F. FEBS Lett. 447 (1999) 61
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(1999)
FEBS Lett.
, vol.447
, pp. 61
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Monks, L.K.1
Cosgrove, K.E.2
Dunne, M.J.3
Ramsden, C.A.4
Morgan, N.G.5
Chan, S.L.F.6
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20
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37649018326
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note
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3, in toluene: see Ref. 1d.
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-
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21
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37649000440
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For the synthesis of racemic 2-ethyl-2,3-dihydrobenzofuran-2-carboxylic acid, see: Ref. 1a-d.
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23
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37649005642
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Mayer, P.; Imbert, T.; Couture, K.; Gouverneur, V.; Mioskowski, C. PCT Int. Appl. WO 00/02836, 2000.
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24
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37649004794
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For the preparation of this acid in an enantioenriched form by resolution of the racemate: (d) Imbert, T.; Mayer, P. PCT Int. Appl. WO 96/35682, 1996.
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25
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37649000604
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For enantioselective syntheses of this acid, see: Ref. 11c.
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27
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37649021313
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For a synthesis of (±)-efaroxan involving nitrile 3, obtained from an ester, see: Mioskowski, C.; Gouverneur, V.; Couture, K.; Lesimple, P.; Autret, J.-M. PCT Int. Appl. WO 00/15624.
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28
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0029045726
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For several references on synthetic applications of arylsulfonylated quinone monoimides, see:
-
For several references on synthetic applications of arylsulfonylated quinone monoimides, see:. Engler T.A., Chai W., and Lynch K.O. Tetrahedron Lett. 36 (1995) 7003
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(1995)
Tetrahedron Lett.
, vol.36
, pp. 7003
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Engler, T.A.1
Chai, W.2
Lynch, K.O.3
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30
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0030272214
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Engler T.A., LaTessa K.O., Iyengar R., Chai W., and Agrios K. Bioorg. Med. Chem. 4 (1996) 1755
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(1996)
Bioorg. Med. Chem.
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Engler, T.A.1
LaTessa, K.O.2
Iyengar, R.3
Chai, W.4
Agrios, K.5
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37
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0034889714
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For a reference on the interest of resin-bound phenyl sulfonyl chloride for solid-supported synthesis:
-
For a reference on the interest of resin-bound phenyl sulfonyl chloride for solid-supported synthesis:. ten Holte P., van Esseveldt B.C.J., Thijs L., and Zwanenburg B. Eur. J. Org. Chem. (2001) 2965
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(2001)
Eur. J. Org. Chem.
, pp. 2965
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ten Holte, P.1
van Esseveldt, B.C.J.2
Thijs, L.3
Zwanenburg, B.4
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38
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0030599260
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The deprotection of phenyl sulfonamide into an amine was described in the literature: first protection of the sulfonamide with a tert-butoxycarbonyl group, then cleavage of the phenyl sulfonyl group using sodium/anthracene and finally deprotection of the BOC group with an acidic hydrolysis:
-
The deprotection of phenyl sulfonamide into an amine was described in the literature: first protection of the sulfonamide with a tert-butoxycarbonyl group, then cleavage of the phenyl sulfonyl group using sodium/anthracene and finally deprotection of the BOC group with an acidic hydrolysis:. Engler T.A., and Chai W. Tetrahedron Lett. 37 (1996) 6969
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(1996)
Tetrahedron Lett.
, vol.37
, pp. 6969
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Engler, T.A.1
Chai, W.2
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39
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33745698682
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For an excellent review on the preparation and synthetic uses of SES amides:
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For an excellent review on the preparation and synthetic uses of SES amides:. Ribière P., Declerck V., Martinez J., and Lamaty F. Chem. Rev. 106 (2006) 2249
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(2006)
Chem. Rev.
, vol.106
, pp. 2249
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Ribière, P.1
Declerck, V.2
Martinez, J.3
Lamaty, F.4
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43
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0037191612
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-
note
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+]; found: 272.0778.
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45
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33748676656
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Benzazepines:
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Benzazepines:. Ribière P., Declerck V., Nédellec Y., Yadav-Bhatnagar N., Martinez J., and Lamaty F. Tetrahedron 62 (2006) 10456
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(2006)
Tetrahedron
, vol.62
, pp. 10456
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Ribière, P.1
Declerck, V.2
Nédellec, Y.3
Yadav-Bhatnagar, N.4
Martinez, J.5
Lamaty, F.6
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46
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4143143021
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β-Aminoesters:
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β-Aminoesters:. Ribière P., Enjalbal C., Aubagnac J.-L., Yadav-Bhatnagar N., Martinez J., and Lamaty F. J. Comb. Chem. 6 (2004) 464
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(2004)
J. Comb. Chem.
, vol.6
, pp. 464
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Ribière, P.1
Enjalbal, C.2
Aubagnac, J.-L.3
Yadav-Bhatnagar, N.4
Martinez, J.5
Lamaty, F.6
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47
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0034104711
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For an excellent review on the transformation of N,N-dialkylhydrazones into various functional groups, including cyano group, see:
-
For an excellent review on the transformation of N,N-dialkylhydrazones into various functional groups, including cyano group, see:. Enders D., Wortmann L., and Peters R. Acc. Chem. Res. 33 (2000) 157
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(2000)
Acc. Chem. Res.
, vol.33
, pp. 157
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Enders, D.1
Wortmann, L.2
Peters, R.3
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48
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37649005061
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note
-
After a 48 h reaction time at 95 °C, the aniline was obtained in a 45% isolated yield, together with the unreacted SES-protected dihydrobenzofuran 7b (52% isolated yield).
-
-
-
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50
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37649023228
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-
note
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2), a complex mixture was obtained among which traces of the deaminated compound 3 were observed.
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-
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-
51
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37649010214
-
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note
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+]; found: 462.1853.
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