Enhanced production of docosahexaenoic acid using Schizochytrium sp. by optimization of medium components

Journal of Chemical Engineering of Japan

Volumn 40, Issue 12, 2007, Pages 1093-1100

  Zhou, Lin ^a   Lu, Yinghua ^a   Zhou, Maohong ^b   Zhao, Xiaowei ^b  

^a XIAMEN UNIVERSITY   (China)

^b WENZHOU UNIVERSITY   (China)

Author keywords

Docosahexaenoic acid (DHA); Medium; Organic nitrogen source; Response surface methodology (RSM); Schizochytrium sp.

Indexed keywords

CARBON; FRUCTOSE; GLUCOSE; NITROGEN; OPTIMIZATION; SALINE WATER; SEAWATER;

MICROBIAL DOCOSAHEXAENOIC ACID; RESPONSE SURFACE METHODOLOGY; SCHIZOCHYTRIUM SP.;

FATTY ACIDS;

CARBON; FATTY ACIDS; FRUCTOSE; GLUCOSE; NITROGEN; OPTIMIZATION; SALINE WATER; SEAWATER;

EID: 37648999855     PISSN: 00219592     EISSN: None     Source Type: Journal    
DOI: 10.1252/jcej.07WE012     Document Type: Article

References (32)

1. Alonso, D. L. and F. G. Maroto; "Plant as 'Chemical Factories' for the Production of Polyunsaturated Fatty Acids," Biotechnol. Adv., 18, 481-497 (2000)
2. Bajpai, P., P. K. Bajpai and O. P. Ward; "Production of Docosahexaenoic Acid by Thraustochytrium aureum," Appl. Microbiol. Biotechnol., 35, 706-710 (1991a)
3. Bajpai, P. K., P. Bajpai and O. P. Ward; "Optimization of Production of Docosahexaenoic Acid (DHA) by Thraustochytrium aureum ATCC 34304," J. Am. Oil Chem. Soc., 68, 509-514 (1991b)
4. Barclay, W. R.; "Process for the Heterotrophic Production of Microbial Oils with High Concentrations of Omega-3 Highly Unsaturated Fatty Acids," U.S. Patent 5,130,242 (1992)
5. Barclay, W. R.; "Process for Growing Thraustochytrium and Schizochytrium Using Non-Chloride Salts to Produce a Micro-Floral Biomass Having Omega-3 Highly Unsaturated Fatty Acids," U.S. Patent 5,340,742 (1994)
6. Bowles, R. D., A. E. Hunt, G. B. Bremer, M. G. Duchars and R. A. Eaton; "Long-Chain n-3 Polyunsaturated Fatty Acid Production by Members of the Marine Protistan Group of the Traustochytrids: Screening of Isolates and Optimisation of Docosahexaenoic Acid Production," J. Biotechnol., 70, 193-202 (1999)
7. Box, G. E. P., W. G. Hunter and 1. S. Hunter; Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Buiding, John Wiley & Sons, New York, U.S.A. (1978)
8. Carlson, S. E.; "Arachidonic Acid Status of Human Infants: Influence of Gestational Age Birth and Diets with Very Long Chain n-3 and n-6 Fatty Acid," J. Nutr., 126, 1092-1098 (1996)
9. Cook, H. C.; "Fatty Acid Desaturation and Chain Elongation in Eukaryote," Biochemistry of Lipids and Membranes, D. E. Vance and J. E. Vance eds., Benjamin/Cummings, Menlo Park, U.S.A. (1985)
10. Das, U. N.; "Long-Chain Polyunsaturated Fatty Acids in the Growth and Development of the Brain and Memory," Nutrition, 19, 62-65 (2003)
11. Fan, K. W., F. Chen, E. B. G. Jones and L. L. P. Vrijmoed; "Eicosapentaenoic and Docosahexaenoic Acids Production by and Okara-Utilizing Potential of Traustochytrids," J. Ind. Microbiol. Biotechnol., 27, 199-202 (2001)
12. Holdsworth, J. E. and C. Ratledge; "Lipids Turnover in Oleaginous Yeasts," J. Gen. Microbiol., 134, 339-346 (1988)
13. Horrocks, L. A. and Y. K. Yeo; "Health Benefits of Docosahexaenoic Acid (DHA)," Pharmacol. Res., 40, 211-225 (1999)
14. Huang, J., T. Aki, K. Hachida, T. Yokochi, S. Kawamoto, S. Shigeta, K. Ono and O. Suzuki; "Profile of Polyunsaturated Fatty Acids Produced by Thraustochytrium sp. KK17-3," J. Am. Oil Chem. Soc., 78, 605-610 (2001)
15. Iida, I., T. Nakahara, T. Yokochi, Y. Kamisaka, H. Yagi, M. Yamaoka and O. Suzuki; "Improvement of Docosahexaenoic Acid Production in a Culture of Thraustochytrium aureum by Medium Optimization," J. Ferment. Bioeng., 81, 76-78 (1996)
16. Innis, S. M.; "Essential Fatty Acid in Growth and Development," Prog. Lipid Res., 30, 39-103 (1994)
17. Kano, K., H. Kikuta, T. Komeda, H. Tsumura, K. Kondo, H. Honda and T. Kobayashi; "Efficient Production of Recombinant Bovine Cathepsin C by High Cell Density Culture of Methylotrophic Yeast Candida boidinii," J. Chem. Eng. Japan, 35, 415-420 (2002)
18. Karthikeyan, R. S., S. K. Rakshit and A. Baradarajan; "Optimization of Batch Fermentation Conditions for Dextran Production," Bioproess Biosystems Eng., 15, 247-252 (1996)
19. Kendrick, A. and C. Ratledge; "Lipids of Selected Molds Grown for the Production of n-3 and n-6 Polyunsaturated Fatty Acids," Lipids, 27, 15-20 (1992)
20. Kennedy, M. and D. Krouse; "Strategies for Improving Fermentation Medium Performance: a Review," J. Ind. Microbiol. Biotechnol., 23, 456-475 (1999)
21. Li, Z. Y. and O. P. Ward; "Production of Docosahexaenoic Acid by Thraustochytrium roseum," J. Ind. Microbiol. Biotechnol., 13, 233-241 (1994)
22. Linko, Y.-Y. and K. Hayakawa; "Docosahexaenoic Acid: A Valuable Nutraceutical?," Trends Food Sci. Technol., 7, 59-63 (1996)
23. Nettleton, J. A.; "Are n-3 Fatty Acids Essential Nutrients for Fetal and Infant Development?," J. Am. Diet. Assoc., 93, 58-64 (1993)
24. Poulos, A.; "Very Long Chain Fatty Acids in Higher Animals - A Review," Lipids, 30, 1-14 (1995)
25. Rose, D. P. and J. M. Connolly; "Omega-3 Fatty Acid as Cancer Chemopreventive Agents," Pharmacol. Therapeut., 83, 217-244 (1999)
26. Sen, R. and T. Swaminathan; "Application of Response-Surface Methodology to Evaluate the Optimum Environmental Conditions for the Enhanced Production of Surfactin," Appl. Microbiol. Biolechnol., 47, 358-363 (1997)
27. Senzaki, H., S. Iwamoto, E. Ogura, Y. Kiyozuka, S. Arita, J. Kurebayashi, H. Takada, K. Hioki and A. Tsubura; "Dietary Effects of Fatty Acids on Growth and Metastasis of KPL-1 Human Breast Cancer Cells in vivo and in vitro," Anticancer Res., 18, 1621-1627 (1998)
28. Shi, F., Z. Xu and P. Cen; "Optimization of γ-Polyglutamic Acid Production by Bacillus subtilis ZJU-7 Using a Surface-Response Methodology," Biotechnol. Bioprocess Eng., 11, 251-257 (2006)
29. Yaguchi, T., S. Tanaka, T. Yokochi, T. Nakahara and T. Higashihara; "Production of High Yields of Docosahexaenoic Acid by Schizochytrium sp. Strain SR21," J. Am. Oil Chem. Soc., 74, 1431-1434 (1997)
30. Yokochi, T., D. Honda, T. Higashihara and T. Nakahara; "Optimization of Docosahexaenoic Acid Production by Schizochytrium limacinum SR21," Appl. Microbiol. Biotechnol., 49, 72-76 (1998)
31. Yongmanitchai, W. and O. P. Ward; "Omega-3 Fatty Acids: Alternative Sources of Production," Proc. Biochem., 24, 117-125 (1989)
32. Zhang, X., T. Ito, K. Kondo, T. Kobayashi and H. Honda; "Production of Single Chain Recombinant Monellin by High Cell Density Culture of Genetically Engineered Candida utilis Using Limited Feeding of Sodium Ions," J. Chem. Eng. Japan, 35, 654-659 (2002)