In vitro and in vivo study on osteocyte-specific mechanical signaling pathways

Journal of Musculoskeletal Neuronal Interactions

Volumn 4, Issue 4, 2004, Pages 386-387

  Yang, W ^a   Kalajzic, I ^b   Lu, Y ^c   Guo, D ^c   Harris, M A ^a   Gluhak Heinrich, J ^a   Bonewald, L F ^c   Feng, J Q ^c   Rowe, D W ^b   Harris, Stephen E ^a,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

DMP1; GFP; Mechanical loading; Microarray; Osteocyte; Pathway

Indexed keywords

ACTIN; CALCIUM CHANNEL L TYPE; GREEN FLUORESCENT PROTEIN; HERMES ANTIGEN; MATRIX PROTEIN; OSTEOPONTIN; PROSTAGLANDIN RECEPTOR; SYNAPTOPHYSIN;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; BONE STRESS; CELL COMMUNICATION; CELL FUNCTION; CELL INTERACTION; CELL MIGRATION; CELL TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; DENDRITIC CELL; DNA MICROARRAY; DNA SEQUENCE; EXTRACELLULAR MATRIX; FLUID FLOW; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; NORTHERN BLOTTING; OSTEOBLAST; OSTEOCYTE; PROTEIN EXPRESSION; SHEAR STRESS; SIGNAL TRANSDUCTION;

ANIMALS; BONE AND BONES; BONE REMODELING; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; OSTEOBLASTS; OSTEOCYTES; OSTEOPONTIN; SIALOGLYCOPROTEINS; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSCRIPTION FACTORS; WEIGHT-BEARING;

EID: 19944428466     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Burger EH, Klein-Nulend J. Mechanotransduction in bone - role of the lacunocanalicular network. Faseb J 1999; 13 Suppl:S101-112.
2. Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD. Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature 2000; 405:704-706.
3. Turner CH, Robling AG, Duncan RL, Burr DB. Do bone cells behave like a neuronal network? Calcif Tissue Int 2002; 70:435-442.
4. Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ, Rosen V, Mundy GR, Harris SE. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and 32 adipocyte lineages. J Cell Biol 1998; 142:295-305.
5. Kato Y, Windle JJ, Koop BA, Mundy GR, Bonewald LF. Establishment of an osteocyte-like cell line, MLO-Y4. J Bone Miner Res 1997; 12:2014-2023.
6. Hsieh YF, Turner CH. Effects of loading frequency on mechanically induced bone formation. J Bone Miner Res 2001; 16:918-924.
7. Toyosawa S, Shintani S, Fujiwara T, Ooshima T, Sato A, Ijuhin N, Komori T. Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts. J Bone Miner Res 2001; 16:2017-2026.
8. Gluhak-Heinrich J, Ye L, Bonewald LF, Feng JQ, MacDougall M, Harris SE, Pavlin D. Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. J Bone Miner Res 2003; 18:807-817.
9. Loots G, Ovcharenko I. rVista 2.0: evolutionary analysis of transcription factor binding sites. Nucleic Acids Research 2004; 32(Web Server Issue):W217-W221.
10. Hughes DE, Salter DM, Simpson R. CD44 expression in human bone: a novel marker of osteocytic differentiation. J Bone Miner Res 1994; 9:39-44.
11. Suzuki K, Zhu B, Rittling SR, Denhardt DT, Goldberg HA, McCulloch CA, Sodek J. Co-localization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J Bone Miner Res 2002; 17:1486-1497.
12. Cheng B, Kato Y, Zhao S, Luo J, Sprague E, Bonewald LF, Jiang JX. PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. Endocrinology 2001; 142:3464-3473.
13. Narayanan K, Ramachandran A, Hao J, He G, Park KW, Cho M, George A. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J Biol Chem 2003; 278:17500-17508.
14. Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet 2002; 31:19-20.
15. Nikitin A, Egorov S, Daraselia N, Mazo I. Pathway studio - the analysis and navigation of molecular networks. Bioinformatics 2003; 19:2155-2157.