Unlocking the molecular basis of obesity

Future Lipidology

Volumn 2, Issue 6, 2007, Pages 577-581

  Gómez Ambrosi, Javier ^a   Frühbeck, Gema ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN; CAVEOLIN; CHEMERIN; GHRELIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; NESFATIN; NEUROPEPTIDE; OMENTIN; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 1; PROTEIN; RETINOL BINDING PROTEIN 4; TRANSCRIPTION FACTOR CLOCK; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOGENESIS; ADIPOSE TISSUE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CENTRAL NERVOUS SYSTEM; CIRCADIAN RHYTHM; COMORBIDITY; EDITORIAL; ENERGY BALANCE; ENERGY EXPENDITURE; ENVIRONMENTAL FACTOR; EPIDEMIC; FOOD INTAKE; GENE FUNCTION; GENE IDENTIFICATION; HEREDITY; HUMAN; HYPOTHALAMUS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM; RISK FACTOR; SIGNAL TRANSDUCTION; SLEEP PATTERN; THERMODYNAMICS; THERMOGENESIS; TISSUE DISTRIBUTION; WAIST CIRCUMFERENCE;

EID: 37549043929     PISSN: 17460875     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460875.2.6.577     Document Type: Editorial

References (37)

1. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW: Central nervous system control of food intake and body weight. Nature 443, 289-295 (2006).
2. Frühbeck G, Gómez-Ambrosi J: Control of body weight: a physiologic and transgenic perspective. Diabetologia 46, 143-172 (2003).
3. Bell CG, Walley AJ, Froguel P: The genetics of human obesity. Nat. Rev. Genet. 6, 221-234 (2005).
4. Frühbeck G: Hunting for new pieces to the complex puzzle of obesity. Proc. Nutr. Soc. 65, 329-347 (2006).
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
6. Farooqi IS, O'Rahilly S: Genetics of obesity in humans. Endocr. Rev. 27, 710-718 (2006).
7. Cummings DE, Schwartz MW: Genetics and pathophysiology of human obesity. Annu. Rev. Med. 54, 453-471 (2003).
8. Bouret SG, Draper SJ, Simerly RB: Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108-110 (2004).
9. Kokoeva MV, Yin H, Flier JS: Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 310, 679-683 (2005).
10. Fulton S, Pissios P, Manchon RP et al.: Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51, 811-822 (2006).
11. Wiedmer P, Nogueiras R, Broglio F, D'Alessio D, Tschöp MH: Ghrelin, obesity and diabetes. Nat. Clin. Pract. Endocrinol. Metab. 3, 705-712 (2007).
12. Oh IS, Shimizu H, Satoh T et al.: Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443, 709-712 (2006).
13. Bray MS, Young ME: Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte. Obes. Rev. 8, 169-181 (2007).
14. Turek FW, Joshu C, Kohsaka A et al.: Obesity and metabolic syndrome in circadian clock mutant mice. Science 308, 1043-1045 (2005).
15. Rosen ED, MacDougald OA: Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7, 885-896 (2006).
16. Wright WS, Longo KA, Dolinsky VW et al.: Wnt10b inhibits obesity in ob/ob and agouti mice. Diabetes 56, 295-303 (2007).
17. Seale P, Kajimura S, Yang W et al.: Transcriptional control of brown fat determination by PRDM16. Cell Metab. 6, 38-54 (2007).
18. Choi CS, Savage DB, Abu-Elheiga L et al.: Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc. Natl Acad. Sci. USA 104, 16480-16485 (2007).
19. Frühbeck G, Gómez-Ambrosi J, Muruzábal FJ, Burrell MA: The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am. J. Physiol. Endocrinol. Metab. 280, E827-E847 (2001).
20. Wood IS, Trayhurn P: Adipokines and the signaling role of adipose tissue in inflammation and obesity. Future Lipidol. 1, 81-89 (2006).
21. de Souza Batista CM, Yang RZ, Lee MJ et al.: Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56, 1655-1661 (2007).
22. Yang Q, Graham TE, Mody N et al.: Serum retinol binding protein 4 contributes to insulin resistance in obesity and Type 2 diabetes. Nature 436, 356-362 (2005).
23. Klöting N, Graham TE, Berndt J et al.: Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab. 6, 79-87 (2007).
24. Janke J, Engeli S, Boschmann M et al.: Retinol-binding protein 4 in human obesity. Diabetes 55, 2805-2810 (2006).
25. Bozaoglu K, Bolton K, McMillan J et al.: Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 148, 4687-4694 (2007).
26. Frühbeck G, Catalán V, Gómez-Ambrosi J, Rodríguez A: Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways. Trends Pharmacol. Sci. 27, 345-347 (2006).
27. Frühbeck G: Obesity: aquaporin enters the picture. Nature 438, 436-437 (2005).
28. Ceperuelo-Mallafré V, Miranda M, Chacón MR et al.: Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in Type 2 diabetes. J. Clin. Endocrinol. Metab. 92, 3640-3645 (2007).
29. Frühbeck G, López M, Diéguez C: Role of caveolins in body weight and insulin resistance regulation. Trends Endocrinol. Metab. 18, 177-182 (2007).
30. Catalán V, Gómez-Ambrosi J, Rodríguez A et al.: Expression of caveolin-1 in human adipose tissue is up-regulated in obesity and obesity-associated Type 2 diabetes mellitus and related to inflammation. Clin. Endocrinol. DOI: 10.1111/ j.1365-2265.2007.03021.x (2007) (Epub ahead of print).
31. Lee NK, Sowa H, Hinoi E et al.: Endocrine regulation of energy metabolism by the skeleton. Cell 130, 456-469 (2007).
32. Gómez-Ambrosi J, Catalán V, Ramírez B et al.: Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J. Clin. Endocrinol. Metab. 92, 3719-3727 (2007).
33. Nomiyama T, Perez-Tilve D, Ogawa D et al.: Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J. Clin. Invest. 117, 2877-2888 (2007).
34. Matsuzaka T, Shimano H, Yahagi N et al.: Crucial role of a long-chain fatty acid elongase, Elov16, in obesity-induced insulin resistance. Nat. Med. 13, 1193-1202 (2007).
35. Gómez-Ambrosi J, Catalán V, Diez-Caballero A et al.: Gene expression profile of omental adipose tissue in human obesity. FASEB J. 18, 215-217 (2004).
36. Frayling TM, Timpson NJ, Weedon MN et al.: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007).
37. Pietiläinen KH, Sysi-Aho M, Rissanen A et al.: Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects - a monozygotic twin study. PLoS ONE 2, e218 (2007).