hMLH1, hMSH2 and cyclooxygenase-2 (Cox-2) in sporadic colorectal polyps

Anticancer Research

Volumn 27, Issue 6 C, 2007, Pages 4465-4471

  Balbinotti, Raul Angelo ^a,c   Ribeiro Jr , Ulysses ^b   Sakai, Paulo ^b   Safatle Ribeiro, Adriana Vaz ^b   Balbinotti, Silvana Sartori ^a   Scapulatempo, Cristovam ^b   Alves, Venancio Avancini Ferreira ^b   Corbett, Carlos Eduardo Pereira ^b   Carrilho, Flair José ^b  

^a UNIVERSITY OF CAXIAS DO SUL   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c NONE   (Brazil)

Author keywords

Adenomas; Colorectal cancer; Cox 2; hMLH1; hMSH2; Immunohistochemistry; Polyps

Indexed keywords

CYCLOOXYGENASE 2; PROTEIN MLH1; PROTEIN MSH2;

ADULT; AGED; ARTICLE; COLON POLYP; COLONOSCOPY; COLORECTAL ADENOMA; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM POLYP;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COLONIC POLYPS; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PRECANCEROUS CONDITIONS; RECTUM;

EID: 37549039407     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. INCA - Ministério da Saúde: Estimativa da incidência e mortalidade por cancer no Brasil - 2006. http://www.inca.gov.br/ epidemiologia.
2. Grizzle WE, Shibata D, Manne U, Myers RB, Frost AR, Srivastava S, Henson DE, Gazdar A (eds.). Molecular Pathology of Early Cancer, Washington DC, IOS Press, pp. 135-170, 1999.
3. Chung CC: The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. Gastroenterology 119: 854-865, 2000.
4. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN and Srivastava S: National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58: 5248-5257, 1998.
5. Baron JA and Sandler RS: Nonsteroidal anti-inflammatory drugs and cancer prevention. Ann Rev Med 51: 511-523, 2000.
6. Srivastava S, Verma M and Henson DE: Biomarkers for early detection of colon cancer. Clin Cancer Research 7: 1118-1126, 2000.
7. Lynch PM, Wargovich MJ, Lynch HT, Palmer C, Lanspa S, Drouhard T and Lynch J: A follow-up study of colonic epithelial proliferation as a biomarker in a Native American family with hereditary nonpolyposis colon cancer. J Natl Cancer Inst (Bethesda) 83: 951-954, 1991.
8. Lynch HT, Lemon SJ, Karr B, Franklin B, Lynch JF, Watson P, Tinley S, Lerman C and Carter C: Etiology, natural history, management and molecular genetics of hereditary nonpolyposis colorectal cancer (Lynch syndromes): genetic counseling implications. Cancer Epidemiol Biomark Prev 6: 987-991, 1997.
9. Marnett LJ and Dubois RN: Cox-2: a target for colon cancer prevention. Ann Rev Pharmacol Toxicol 42: 55-80, 2002.
10. Hsu SM, Hsu PL and Nayak RN: Warthin's tumor: an immunohistochemical study of its lymphoid stroma. Hum Pathol 12(3): 251-257, 1981.
11. Hsu SM and Raine L: Protein A, avidin, and biotin in immunohistochemistry. J Histochem Cytochem 29(11): 1349-1353, 1981.
12. Shi SR, Key ME and Kalra KL: Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 39(6): 741-748, 1991.
13. Ribeiro U Jr, Safatle-Ribeiro AV, Posner MC, Rosendale B, Bakker A, Swalsky PA, Kim R, Reynolds JC and Finkelstein SD: Comparative p53 mutational analysis of multiple primary cancers of the upper aerodigestive tract. Surg 120(1): 45-53, 1996.
14. Safatle-Ribeiro AV, Ribeiro U Jr, Reynolds JC, Gama-Rodrigues JJ, Iriya K, Kim R, Bakker A, Swalsky PA, Pinotti HW and Finkelstein SD: Morphologic, histologic, and molecular similarities between adenocarcinomas arising in the gastric stump and the intact stomach. Cancer 78(11): 2288-2299, 1996.
15. Safatle-Ribeiro AV, Ribeiro U Jr and Reynolds JC: Gastric stump cancer: what is the risk? Dig Dis 16(3): 159-168, 1998.
16. Ribeiro U Jr., Alves VA, Souza PMSB, Safatle-Ribeiro AV, Rawet V, Nonogaki S, Gama-Rodrigues JJ and Habr-Gama A: Correlaçao das proteinas p53 e Ki-67 com o prognostico de pacientes com adenocarcinoma de reto distal. Rev Bras Coloproct 20(4): 248-256, 2000.
17. Winawer SJ, Fletcher RH, Miller L, Godlee F, Stolar MH, Mulrow CD, Woolf SH, Glick SN, Ganiats TG, Bond JH, Rosen L, Zapka JG, Olsen SJ, Giardiello FM, Sisk JE, Van Antwerp R, Brown-Davis C, Marciniak DA and Mayer RJ: Colorectal cancer screening: clinical guidelines and rationale. Gastroenterol 112: 594-642, 1997.
18. Winawer SJ, Zauber AG, Ho MN, O'Brien MJ, Gottlieb LS, Sternberg SS, Waye JD, Schapiro M, Bond JH, Panish JF, Ackroyd F, Shike M, Kurtz RC, Hornsby-Lewis L, Gerdes H, Stewart ET and The National Polyp Study Workgroup: Prevention of colorectal cancer by colonoscopic polypectomy. N Engl J Med 329: 977-981, 1993.
19. Crawford JM: In: The Gastrointestinal Tract. Cotran RS, Kumar V, Collins T (eds.). Pathologic Basis of Disease. WB Saunders Company, Philadelphia, pp. 802-838, 1999.
20. Lynch HT and Lynch JF: Hereditary nonpolyposis colorectal cancer. Seminars in Surgical Oncology 18: 305-313, 2000.
21. Fearon ER and Volgestein B: A genetic model for colorectal tumorigenisis. Cell 61: 759-767, 1990.
22. Hawkins NJ and Ward RL: Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 93: 1307-1313, 2001.
23. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA and Baylin SB: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95(12): 6870-6875, 1998.
24. Williams CS, Luongo C, Radhika A, Zhang T, Lamps LW, Nanney LB, Beauchamp RD and DuBois RN: Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterol 111: 1134-1140, 1996.
25. Δ716 knockout mice by inhibition of cyclooxygenase-2 (Cox-2). Cell 87: 803-809, 1996.
26. Chulada PC, Thompson MB, Mahler JF, Doyle CM, Gaul BW, Lee C, Tiano HF, Morham SG, Smithies O and Langenbach R: Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res 60: 4705-4708, 2000.
27. Shattuck-Brandt RL, Varilek GW, Radhika A, Yang F, Washington MK and DuBois RN: Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. Gastroenterol 118: 337-345, 2000.
28. Sinicrope FA, Lemoine M, Xi L, Lynch PM, Cleary KR, Shen Y and Frazier ML: Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. Gastroenterol 117: 350-358, 1999.
29. Khan KN, Masferrer JL, Woerner BM, Soslow R and Koki AT: Enhanced cyclooxygenase-2 expression in sporadic and familial adenomatous polyposis of the human colon. Scand J Gastroenterol 36: 865-869, 2001.
30. Keller JJ, Offerhaus GJ, Drillenburg P, Caspers E, Musler A, Ristimäki A and Giardiello FM: Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. Clin Cancer Res 7: 4000-4007, 2001.
31. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S and DuBois RN: Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterol 107: 1183-1188, 1994.
32. Hao X, Bishop AE, Wallace M, Wang H, Willcocks TC, Maclouf J, Polak JM, Knight S and Talbot IC: Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. J Pathol 187: 295-301, 1999.
33. Arao J, Sano Y, Fujii T, Kato S, Fu KI, Yoshino T, Ochiai A, Fujimori T and Yoshida S: Cyclooxygenase-2 is over expressed in serrated adenoma of the colorectum. Dis Colon Rectum 44: 1319-1323, 2001.
34. Bamba H, Ota S, Kato A, Adachi A, Itoyama S and Matsuzaki F: High expression of cyclooxygenase-2 in macrophages of human colonic adenoma. Int J Cancer 83: 470-475, 1999.
35. Chapple KS, Cartwright EJ, Hawcroft G, Tisbury A, Bonifer CScott N, Windsor AC, Guillou PJ, Markham AF, Coletta PL and Hull MA: Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. Am J Pathol 156: 545-553, 2000.
36. Maekawa M, Sugano K, Sano H, Miyazaki S, Ushiama M, Fujita S, Gotoda T, Yokota T, Ohkura H, Kakizoe T and Sekiya T: Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. Jpn J Clin Oncol 28(7): 421-426, 1998.