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Volumn 18, Issue 1, 2008, Pages 309-312

4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity

Author keywords

4 Aminopyridine derivatives; Acetylcholinesterase; Antiamnesic effects; Butyrylcholinesterase

Indexed keywords

4 AMINOPYRIDINE DERIVATIVE; CARBAMIC ACID DERIVATIVE; CHOLINERGIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE;

EID: 37549036692     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.077     Document Type: Article
Times cited : (14)

References (24)
  • 6
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    • Olin, J.; Schneider, L. Cochrane database of systematic reviews 2001, 4, CD001747.
  • 7
    • 42749100518 scopus 로고    scopus 로고
    • Birks, J. Cochrane Database of Systematic Reviews 2006, 1, CD005593.
  • 8
    • 37549035575 scopus 로고    scopus 로고
    • Carelli, V.; Liberatore, F.; Scipione, L.; Rotiroti, D.; Rispoli, V.; Cardellini M, Patent IT MI 2000 A000898 (2000), EP 1925883.(2001).
  • 18
    • 37549033634 scopus 로고    scopus 로고
    • note
    • Passive avoidance performance test was carried out according to the step-through method described by Giovannini (Behaviour Brain Research 1999, 104: 147-155). The time elapsed between the rat was placed in the light and it entered the dark compartment is recorded as Training Trial latency time (TT). Amnesia was induced in rats with scopolamine (0.5 mg/kg) given subcutaneously 1 h before Training Trial. Rats received intraperitoneally the compounds under study (4-AP, 3a, 4a, 4d) or vehicle (saline) 30 min after scopolamine treatment. Compound 1 was given 15 min before Training Trial. In a second set of experiments 1 was combined with 4-AP following the same experimental protocol. Retention trial was performed 24 h later, following a similar procedure, except that the electric shock was not given. The latency time to enter the dark compartment was measured up to a cut off time of 180 s and indicated as Retention Trial latency time (RT). Experiments were done in compliance with the recommendations of the EEC 886/609/CEE and in accordance with the national laws (DL 116/92).
  • 20
    • 37549042573 scopus 로고    scopus 로고
    • note
    • 13C NMR and analytical data are reported in supplementary material.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.