Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert

Neuroscience Letters

Volumn 356, Issue 3, 2004, Pages 199-202

  Rispoli, Vincenzo ^a   Rotiroti, Domenicantonio ^a   Carelli, Vincenzo ^b   Liberatore, Felice ^b   Scipione, Luigi ^b   Marra, Rosario ^c   Giorgioni, Gianfabio ^d   Di Stefano, Antonio ^d  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

^d UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Cholinergic neurotransmission; Learning and memory impairment; Lesioned nucleus basalis magnocellularis; Scopolamine

Indexed keywords

CHOLINE DERIVATIVE; SCOPOLAMINE; TACRINE; UNCLASSIFIED DRUG; [2 (2,2 DIMETHYLPROPIONYLOXY)ETHYL]TRIMETHYLAMMONIUM 2,2 DIMETHYLPROPIONATE; [2 (2,2 DIMETHYLPROPIONYLOXY)ETHYL]TRIMETHYLAMMONIUM IODIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CHOLINERGIC TRANSMISSION; COGNITIVE DEFECT; CONTROLLED STUDY; DISCRIMINATION LEARNING; DRUG EFFECT; GIANT CELL; MALE; MAZE TEST; MEMORY DISORDER; MEYNERT BASAL NUCLEUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; TASK PERFORMANCE;

EID: 0442292146     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.11.054     Document Type: Article

References (15)

1. Alcaro S., Scipione L., Ortuso F., Posca S., Rispoli V., Rotiroti D. Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase. Bioorg. Med. Chem. Lett. 12:2002;2899-2905.
2. Bartolini L., Casamenti F., Pepeu G. Aniracetam restores object recognition impaired by age, scopolamine and nucleus basalis lesion. Pharmacol. Biochem. Behav. 53:1996;277-283.
3. Beatty W.W., Buters N., Janowsky D.S. Patterns of memory failure after scopolamine treatment implications for cholinergic hypothesis of dementia. Behav. Neural. Biol. 45:1986;196-211.
4. V. Carelli, F. Liberatore, L. Scipione, D. Rotiroti, V. Rispoli, M. Cardellini, Choline derivatives for the treatment of Alzheimer's disease, patent IT MI2000A000898-21-4-2000, EP 01925883.9-10-4-2001. C.A. 135 (2001) 344212M.
5. Durkin T.P. Spatial working memory over long retention intervals: dependence on sustained cholinergic activation in the septohippocampal or nucleus basalis magnocellularis-cortical pathway? Neuroscience. 62:(3):1994;681-693.
6. Ennaceur A., Delacour J. A new one trial test for neurobiological studies of memory in rats. I: behavioural data. Behav. Brain Res. 31:1988;47.
7. Everitt B.J., Robbins T.W. Central cholinergic system and cognition. Ann. Rev. Psychol. 48:1997;649-684.
8. Lo Conte G., Casamenti F., Bigl V., Milaneschi E., Pepeu G. Effect of magnocellular forebrain nuclei lesions on acetylcholine output from the cerebral cortex, electrocorticogram and behaviour. Arch. Ital. Biol. 120:1982;176-188.
9. Morris R.G.M. Development of a water maze procedure for studying spatial learning in the rat. J. Neurosci. Methods. 11:1984;47-60.
10. Muir J.L., Page K.J., Sirinathsinghji D.J.S., Robbins T.W., Everitt B.J. Excitotoxic lesion of basal forebrain cholinergic neurons: effects on learning, memory and attention. Behav. Brain Res. 57:1993;123-131.
11. Paxinos G., Watson C. The Rat Brain in the Stereotaxic Coordinates. 1980;Academic Press, New York.
12. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron. 6:1991;487-498.
13. Steven R. Scopolamine impairs spatial maze performance in rats. Physiol. Behav. 27:1981;385-386.
14. Thaney-Wyss P., Waser P. Interaction of quaternary ammonium compounds with acetylcholinesterase: characterization of the active site. Eur. J. Pharmacol. Mol. Pharmacol. Section. 172:(2):1989;165-173.
15. Yoshida S., Suzuki N. Antiamnesic and cholinomimetic side effects of the cholinesterase inhibitors, physostgmine, taurine and NIK-247 in rats. Eur. J. Pharmacol. 150:1993;117-124.