Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Leprfa) rat

Biochemical and Biophysical Research Communications

Volumn 366, Issue 2, 2008, Pages 556-562

  Akimoto, Toshio ^a   Nakama, Kazumasa ^b   Katsuta, Yasumi ^a   Zhang, Xue Jun ^a   Ohsuga, Masaru ^a   Ishizaki, Masamichi ^a   Sawai, Nobuhiko ^a   Ozawa, Hitoshi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Shizuoka Laboratory Animal Center   (Japan)

Author keywords

Congenic strain; Diabetes; Fatty; Leptin receptor; Obesity; Pancreatitis; WBN Kob rat

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CHRONIC PANCREATITIS; CONGENIC STRAIN; DIABETES MELLITUS; DIABETIC FATTY RAT; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GENE MUTATION; INFLAMMATION; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS; PRIORITY JOURNAL;

ANIMALS; ANIMALS, CONGENIC; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; LEPTIN; OBESITY; PANCREATITIS; RATS; RECEPTORS, LEPTIN;

ANIMALIA; RATTUS;

EID: 37449011255     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.003     Document Type: Article

References (26)

1. Tsuchitani M., Saegusa T., Narama I., Nishikawa T., and Gonda T. A new diabetic strain of rat (WBN/Kob). Lab. Anim. 19 (1985) 200-207
2. Mori Y., Yokoyama J., Nishimura M., Kurata H., Miura J., and Ikeda Y. Diabetic strain (WBN/Kob) of rat characterized by endocrine-exocrine pancreatic impairment due to distinct fibrosis. Pancreas 5 (1990) 452-459
3. Nakama K., Shichinohe K., Kobayashi K., Naito K., Uchida O., Yasuhara K., and Tobe M. Spontaneous diabetes-like syndrome in WBN/KOB rats. Acta Diabetol. Lat. 22 (1985) 335-342
4. Tsuji A., Nishikawa T., Mori M., Suda K., Nishimori I., and Nishimura M. Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. Genomics 74 (2001) 365-369
5. Zucker L.M. Hereditary obesity in the rat associated with hyperlipemia. Ann. N. Y. Acad. Sci. 131 (1965) 447-458
6. Chua Jr. S.C., White D.W., Wu-Peng X.S., Liu S.M., Okada N., Kershaw E.E., Chung W.K., Power-Kehoe L., Chua M., Tartaglia L.A., and Leibel R.L. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45 (1996) 1141-1143
7. Leonard B.L., Watson R.N., Loomes K.M., Phillips A.R., and Cooper G.J. Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes. Acta Diabetol. 42 (2005) 162-170
8. Ikeda H., Shino A., Matsuo T., Iwatsuka H., and Suzuoki Z. A new genetically obese-hyperglycemic rat (Wistar fatty). Diabetes 30 (1981) 1045-1050
9. Friedman J.E., Vente de J.E., Peterson R.G., and Dohm G.L. Altered expression of muscle glucose transporter GLUT-4 in diabetic fatty Zucker rats (ZDF/Drt-fa). Am. J. Physiol. 261 (1991) E782-E788
10. Michaelis O.E., Ellwood K.C., Judge J.M., Schoene N.W., and Hansen C.T. Effect of dietary sucrose on the SHR/Ncorpulent rat: a new model for insulin-independent diabetes. Am. J. Clin. Nutr. 39 (1984) 612-618
11. Masuyama T., Katsuda Y., and Shinohara M. A novel model of obesity-related diabetes: introgression of the Lepr(fa) allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats. Exp. Anim. 54 (2005) 13-20
12. Chen C.C., Wang S.S., Lee F.Y., Chang F.Y., and Lee S.D. Proinflammatory cytokines in early assessment of the prognosis of acute pancreatitis. Am. J. Gastroenterol. 94 (1999) 213-218
13. Gukovskaya A.S., Gukovsky I., Zaninovic V., Song M., Sandoval D., Gukovsky S., and Pandol S.J. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. J. Clin. Invest. 100 (1997) 1853-1862
14. Steer M.L. The early intraacinar cell events which occur during acute pancreatitis. Pancreas 17 (1998) 31-37
15. Konturek P.C., Jaworek J., Maniatoglou A., Bonior J., Meixner H., Konturek S.J., and Hahn E.G. Leptin modulates the inflammatory response in acute pancreatitis. Digestion 65 (2002) 149-160
16. Jaworek J., Bonior J., Pierzchalski P., Tomaszewska R., Stachura J., Sendur R., Leja A., Jachimczak B., Konturek P.C., Bielański W., Pawlik W., and Konturek S.J. Leptin protects the pancreas from damage induced by caerulein overstimulation by modulating cytokine production. Pancreatology 2 (2002) 89-99
17. Cameron J.L., Capuzzi D.M., Zuidema G.D., and Margolis S. Acute pancreatitis with hyperlipemia: the incidence of lipid abnormalities in acute pancreatitis. Ann. Surg. 177 (1973) 483-489
18. Nordstoga K., Christophersen B., Ytrehus B., Espenes A., Osmundsen H., Landsverk T., Olivecrona T., and Olivecrona G. Pancreatitis associated with hyperlipoproteinaemia type I in mink (Mustela vison): earliest detectable changes occur in mitochondria of exocrine cells. J. Comp. Pathol. 134 (2006) 308-320
19. Yan M.X., Li Y.Q., Meng M., Ren H.B., and Kou Y. Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia. Biochem. Biophys. Res. Commun. 347 (2006) 192-199
20. Martinez J., Sanchez-Paya J., Palazon J.M., Aparicio J.R., Pico A., and Perez-Mateo M. Obesity: a prognostic factor of severity in acute pancreatitis. Pancreas 19 (1999) 15-20
21. Funnell I.C., Bornman P.C., Weakley S.P., Terblanche J., and Marks I.N. Obesity: an important prognostic factor in acute pancreatitis. Br. J. Surg. 80 (1993) 484-486
22. Mery C.M., Rubio V., Duarte-Rojo A., Suazo-Barahona J., Pelaez-Luna M., Milke P., and Robles-Diaz G. Android fat distribution as predictor of severity in acute pancreatitis. Pancreatology 2 (2002) 543-549
23. Segersvard R., Sylvan M., Herrington M., Larsson J., and Permert J. Obesity increases the severity of acute experimental pancreatitis in the rat. Scand. J. Gastroenterol. 36 (2001) 658-663
24. Hashimoto T., Yamada T., Yokoi T., Sano H., Ando H., Nakazawa T., Ohara H., Nomura T., Joh T., and Itoh M. Apoptosis of acinar cells is involved in chronic pancreatitis in Wbn/Kob rats: role of glucocorticoids. Pancreas 21 (2000) 296-304
25. Nakamura S., Yamada T., Hashimoto T., Takahashi S., Sogawa M., Ohara H., Nakazawa T., Sano H., Kuno A., Joh T., Nomura T., and Arakawa T. Estradiol alleviates acinar cell apoptosis and chronic pancreatitis in male Wistar Bonn/Kobori rats. Pancreas 26 (2003) e59-e66
26. Garris D.R. Diabetes-associated alterations in uterine structure in the C57BL/KsJ mouse: relationship to changes in estradiol accumulation, circulating ovarian steroid levels, and age. Anat. Rec. 211 (1985) 414-419