Estradiol alleviates acinar cell apoptosis and chronic pancreatitis in male wistar bonn/kobori rats

Nursing

Volumn 26, Issue 3, 1996, Pages

  Nakamura, Soichi ^a   Yamada, Tamaki ^a   Hashimoto, Takashi ^b   Takahashi, Satoru ^a   Ohara, Hirotaka ^a   Nakazawa, Takahiro ^a   Sano, Hitoshi ^a   Kuno, Atsushi ^a   Joh, Takashi ^a   Nomura, Tomoyuki ^a   Arakawa, Tetsuo ^c   Itoh, Makoto ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acinar cell; Apoptosis; Corticosterone; Sex hormones

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; ESTRADIOL; FLUTAMIDE; HORMONE; HYDROXYPROLINE;

ANIMAL; APOPTOSIS; ARTICLE; BLOOD; BODY WEIGHT; CELL MOTION; CHRONIC DISEASE; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; MALE; ORGAN SIZE; PANCREAS; PANCREATITIS; PATHOLOGY; RAT; RAT STRAIN; SPLEEN; T LYMPHOCYTE; WISTAR RAT;

ANDROGEN ANTAGONISTS; ANIMALS; APOPTOSIS; BODY WEIGHT; CELL MOVEMENT; CHRONIC DISEASE; ESTRADIOL; FLUTAMIDE; HORMONES; HYDROXYPROLINE; MALE; ORGAN SIZE; PANCREAS; PANCREATITIS; RATS; RATS, INBRED STRAINS; RATS, WISTAR; RECEPTORS, ANDROGEN; SPLEEN; T-LYMPHOCYTES;

EID: 1542681219     PISSN: 03604039     EISSN: 15388689     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Mori Y, Yokoyama J, Nishimura M, et al. A new diabetic strain of rat with exocrine pancreatic insufficiency. In: Tiengo A, Del Prato S, Alberti KG, et al., eds. Diabetes secondary to pancreatopathy. Amsterdam: Elsevier; 1988:107-112.
2. Ohashi K, Kim J-H, Hara H, et al. WBN/Kob rats: a new spontaneously occurring model of chronic pancreatitis. Int J Pancreatol. 1990; 6:231-247.
3. Tsuchitani M, Saegusa T, Narama I, et al. A new diabetic strain of rat (WBN/Kob). Lab Anim. 1985; 19:200-207.
4. Hashimoto T, Yamada T, Yokoi T, et al. Apoptosis of acinar cells is involved in chronic pancreatitis in WBN/Kob rats: role of glucocorticoids. Pancreas 2000; 21:296-304.
5. Yamada T, Hashimoto T, Sogawa M, et al. Involvement of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: protective effects of tacrolimus. Am J Physiol. 2001; 281:G1397-1404.
6. Cutolo M, Sulli A, Seriolo B, et al. Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol. 1995; 13:217-226.
7. Allen JB, Blatter D, Calandra GB, et al. Sex hormonal effects on the severity of streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 1983; 26:560-563.
8. Grossman C. Possible underlying mechanisms of sexual dimorphism in the immune responses, fact and hypothesis. J Steroid Biochem. 1989; 34:241-251.
9. Hawkins T, Gala RR, Dunbar JC. The effect of neonatal sex hormone manipulation on the incidence of nonobese diabetes. Proc Soc Exp Biol. 1993; 202:201-205.
10. Makino S, Kunimoto K, Muraoka Y, et al. Effect of castration on the appearance of diabetes in NOD mouse. Exp Anim 1981; 30:137-140.
11. Nakama K, Akimoto T, Shimizu M, et al. Inhibitory effect of estrogen on the development of diabetic symptoms in male WBN/Kob rats [in Japanese]. Diabetic Animal, 2, IYAKU Journal, Osaka, 1988:130-136.
12. Ohashi K, Hara H, Aso R, et al. Effects of various drugs on chronic pancreatitis-like lesions in WBN/Kob rat [in Japanese]. Jikken Dobutsu. Exp Anim. 1989; 3:169-177.
13. Yamada T, Hoshino M, Hayakawa T, et al. Dietary diosgenin attenuates subacute intestinal inflammation associated with indomethacin in rats. Am J Physiol. 1997; 273:G355-364.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992; 119:209-214.
15. Shirai T, Takahashi S, Mori T, et al. Immunohistochemically demonstrated androgen receptor expression in the rat prostate during carcinogenesis induced by 3, 2´-dimethyl-4-aminobiphenyl with and without testosterone. Urol Oncol. 1995; 1:263-268.
16. Grisham MB, Benoit JN, Granger DN. Assessment of leukocyte involvement during ischemia and perfusion of intestine. Method Enzymol. 1990; 186:729-741.
17. Blumenkrantz N, Asobe-Hansen G. A quick and specific assay for hydroxyproline. Anal Biochem. 1973; 55:288-291.
18. Ueberberg H, Laque K, Trieb G. Comparative studies on the circadian rhythm of corticosterone lipid and cholesterol levels in adrenals and blood of rats. Chronobiol Int. 1984; 1:41-49.
19. Asakawa N, Koyama M, Hashimoto Y, et al. Studies on the metabolic fate of flutamide (4); biliary secretion, enterohepatic circulation, absorption from gastro-intestinal tract, metabolism and drug-metabolizing enzymes induction in rats. Drug Metabolism (Yakubutsu Dotai). 1995; 10:470-483.
20. Jung CG, Kamiyama T, Agui T. Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats. Immunology. 1999; 98:590-594.
21. Elder ME, Maclaren NK. Identification of profound peripheral T-lymphocyte immunodeficiencies in the spontaneously diabetic BB rat. J Immunol. 1983; 130:1723-1731.
22. Rijhsinghani AG, Thompson K, Bhatia SK, et al. Estrogen blocks early T cell development in the thymus. Am J Reprod Immunol. 1996; 36:269-277.
23. Bateman A, Singh A, Kral T, et al. The immune-hypothalamic-pituitary-adrenal axis. Endocr Rev. 1989; 10:92-112.
24. Kimura K, Shimosegawa T, Sasano H, et al. Endogenous glucocorticoids decrease the acinar cell sensitivity to apoptosis during caerulein pancreatitis in rats. Gastroenterology. 1998; 114:372-381.
25. Felig P, Baxter JD, Frohman LA. Endocrinology and metabolism. In: William FG, ed. Review of medical physiology. New York: McGraw-Hill, 1981:218-270.
26. Richard RG, Ulrich W. Corticosteroid-binding globulin in the rat: studies on the sex difference. Endocrinology. 1965; 77:841-851.
27. Roubinian JR, Talal N, Greenspan JS, et al. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW1 mice. J Exp Med. 1978; 147:1568-1583.
28. Corbishley TP, Iqbal MJ, Wilkinson ML, et al. Androgen receptor in human and malignant pancreatic tissue cell lines. Cancer. 1986; 57:1992-1995.
29. Diaz-Sanchez V, Morimoto S, Morales A, et al. Androgen receptor in the rat pancreas: genetic statement and steroid regulation. Pancreas. 1995; 11:241-245.
30. Pousette Å. Demonstration of an androgen receptor in rat pancreas. Biochem J. 1976; 157:229-232.
31. Brooks JR, Berman C, Nguyen H, et al. Effect of castration, DES, flutamide, and the 5α-reductase inhibitor, MK-906, on the growth of the Dunning rat prostatic carcinoma, R-3327. Prostate. 1991; 18:215-217.
32. Aso Y, Akaza H, Kumamoto Y, et al. Phase I study of flutamide, a nonsteroidal antiandrogen, in patients with prostatic cancer. Acta Urol Jpn. 1993; 38:381-389.
33. Luster MI, Hayes HT, Korach K, et al. Estrogen immunosuppression is regulated through estrogenic responses in the thymus. J Immunol. 1984; 133:110-116.
34. Shimizu I, Mizobuchi Y, Yasuda M, et al. Inhibitory effect of estradiol on activation of rat hepatic stellate cells in vivo and in vitro. Gut. 1999; 44:127-136.
35. Yasuda M, Shimizu I, Shibata M, Ito S. Suppressive effect of estradiol on dimethylnitrosamine-induced fibrosis in rats. Hepatology. 1999; 29:719-727.