Comparative radical-scavenging activity of curcumin and tetrahydrocurcumin with thiols as measured by the induction period method

In Vivo

Volumn 21, Issue 6, 2007, Pages 979-982

  Kadoma, Yoshinori ^a   Fujisawa, Seiichiro ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

Curcumin; Induction period method; Radical scavenging activity; Tetrahydrocurcumin; Thiol

Indexed keywords

ANTIOXIDANT; BENZOYL PEROXIDE; BUTYRONITRILE; CURCUMIN; FREE RADICAL; GLUTATHIONE; METHACRYLIC ACID METHYL ESTER; TETRAHYDROCURCUMIN; THIAMAZOLE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DECOMPOSITION; DRUG POTENTIATION; HUMAN; HUMAN CELL; IN VIVO STUDY; METHODOLOGY; POLYMERIZATION; SCAVENGING SYSTEM; STOICHIOMETRY;

EID: 37349085066     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Atsumi T, Fujisawa S and Tonosaki K: Relationship between intracellular ROS production and membrane mobility in curcumin- and tetrahydrocurcumin-treated human gingival fibroblasts and human submandibular gland carcinoma cells. Oral Diseases 11: 236-242, 2005.
2. Atsumi T, Tonosaki K and Fujisawa S: Comparative cytotoxicity and ROS generation by curcumin and tetrahydrocurcumin following visible-light irradiation or treatment with horseradish peroxidase. Anticancer Res 27: 363-372, 2007.
3. Atsumi T, Murakami Y, Shibuya K, Tonosaki K and Fujisawa S: Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, α-diisoeugenol. Anticancer Res 25: 4029-4036, 2005.
4. Fujisawa S, Atsumi T, Ishihara M and Kadoma Y: Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds. Anticancer Res 24: 563-570, 2004.
5. Pari L and Amali DR: Protective tole of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity. J Pharm Pharm Sci 8: 115-123, 2005.
6. Murugan P and Pari L: Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats. Life Sci 79: 1720-1728, 2006.
7. Murugan P and Pari L: Effect of tetrahydrocurcumin on lipid peroxidation and lipids in streptozotocin-nicotinamide induced diabetic rats. Basic Clin Pharmacol Toxicol 99: 122-127, 2006.
8. Somparn P, Phisalaphong C, Nakornchai S, Unchern S and Morales NP: Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull 30: 74-78, 2007.
9. Sugiyama Y, Kawakishi S and Osawa T: Involvement of the beta-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin. Biochem Pharmacol 23: 519-525, 1996.
10. Fujisawa S and Kadoma K: Anti-and pro-oxidant effects of oxidized quercetin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period method. In Vivo 20: 39-44, 2006.
11. Burton GW and Ingold KU: β-Carotene: an unusual type of lipid antioxidant. Science 224: 569-573, 1984.
12. Szent-Gyorgy A: The living state and cancer. Physico Chem Phys 12: 99-110, 1980.
13. Boots AW, Kubben N, Haenen GR and Bast A: Oxidized quercetin reacts with thiols rather than with ascorbate: implication of quercetin supplementation. Biochem Biophys Res Commun 308: 560-565, 2003.
14. Galati G, Sabzevari O, Wilson JX and O'Brien PJ: Prooxidant activity and cellular effects of the phenoxy radicals of dietary flavonoids and other polyphenolics. Toxicology 177: 91-104, 2002.
15. Hotta H, Sakamoto H, Nakano S, Osaki T and Tsujimoto Y: Unusually large number of electrons for the oxidation of polyphenolic antioxidants. Biochem Biophys Acta 1526: 159-167, 2001.
16. Masuda T, Hidaka K, Shinohara A, Maekawa T, Takeda Y and Yamaguchi H: Chemical studies on antioxidant mechanism of curcuminoide: analysis of radical reaction products from curcumin. J Agric Food Chem 47: 71-77, 1999.
17. Masuda T, Toi Y, Bando H, Maekawa T, Takeda Y and Yamaguchi H: Structural identification of new curcumin dimmers and their contribution to the antioxidant mechanism of curcumin. J Angric Food Chem 50: 2524-2530, 2002.