Image-Guided Convection-Enhanced Delivery Platform in the Treatment of Neurological Diseases

Neurotherapeutics

Volumn 5, Issue 1, 2008, Pages 123-127

  Fiandaca, Massimo S ^a,b   Forsayeth, John R ^a   Dickinson, Peter J ^c   Bankiewicz, Krystof S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LifeBridge Health   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

brain neoplasm; CNS; Convection enhanced delivery; gene transfer; infusion cannula; liposomes; MRI; Parkinson's disease; trophic factors

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATIC CARBOXYLIC ACID; BIOPOLYMER; CARBOXYLYASE; CARMUSTINE; CONTRAST MEDIUM; DRUG CARRIER; GADOLINIUM PENTETATE; GADOTERIDOL; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; IMMUNOTOXIN; INTERLEUKIN 13 PE38QQR; IRINOTECAN; LIPOSOME; NITROSOUREA DERIVATIVE; PARVOVIRUS VECTOR; TRANSFERRIN; TRANSFERRIN CRM107; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN TUMOR; CANNULA; CATHETER; CENTRAL NERVOUS SYSTEM; CONTRAST ENHANCEMENT; CONVECTION ENHANCED DELIVERY; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG INFUSION; DRUG MEGADOSE; GENE TRANSFER; GLIOBLASTOMA; GLIOMA; HUMAN; MEDICAL TECHNOLOGY; NANOTECHNOLOGY; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PRIORITY JOURNAL; STEREOTACTIC RADIOSURGERY; THREE DIMENSIONAL IMAGING; TREATMENT PLANNING; TUMOR VOLUME; VIRAL GENE DELIVERY SYSTEM;

DRUG DELIVERY SYSTEMS; HUMANS; MAGNETIC RESONANCE IMAGING; NERVOUS SYSTEM DISEASES;

EID: 37349081554     PISSN: 19337213     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nurt.2007.10.064     Document Type: Article

References (44)

1. Oldendorf W.H. Lipid solubility and drug penetration of the blood brain barrier. Proc Soc Exp Biol Med 147 (1974) 813-815
2. Neuwelt E.A. Mechanisms of disease: the blood-brain barrier. Neurosurgery 54 (2004) 131-140 discussion 141-132
3. Motl S., Zhuang Y., Waters C.M., and Stewart C.F. Pharmacokinetic considerations in the treatment of CNS tumours. Clin Pharmacokinet 45 (2006) 871-903
4. Kroll R.A., and Neuwelt E.A. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 42 (1998) 1083-1099 discussion 1099-1100
5. Feugier P., Van Hoof A., Sebban C., et al. Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 23 (2005) 4117-4126
6. Nowakowski G.S., and Witzig T.E. Radioimmunotherapy for B-cell non-Hodgkin lymphoma. Clin Adv Hematol Oncol 4 (2006) 225-231
7. Doolittle N.D., Miner M.E., Hall W.A., et al. Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors. Cancer 88 (2000) 637-647
8. Jahnke K., Doolittle N.D., Muldoon L.L., and Neuwelt E.A. Implications of the blood-brain barrier in primary central nervous system lymphoma. Neurosurg Focus 21 (2006) E11
9. Brem H., Mahaley Jr. M.S., Vick N.A., et al. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J Neurosurg 74 (1991) 441-446
10. Mardor Y., Roth Y., Lidar Z., et al. Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging. Cancer Res 61 (2001) 4971-4973
11. Kunwar S. Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies. Acta Neurochir Suppl 88 (2003) 105-111
12. Lidar Z., Mardor Y., Jonas T., et al. Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: a phase I/II clinical study. J Neurosurg 100 (2004) 472-479
13. Gill S.S., Patel N.K., Hotton G.R., et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 9 (2003) 589-595
14. Patel N.K., Bunnage M., Plaha P., Svendsen C.N., Heywood P., and Gill S.S. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Ann Neurol 57 (2005) 298-302
15. Brem H., and Gabikian P. Biodegradable polymer implants to treat brain tumors. J Control Release 74 (2001) 63-67
16. Fleming A.B., and Saltzman W.M. Pharmacokinetics of the carmustine implant. Clin Pharmacokinet 41 (2002) 403-419
17. Gallia G.L., Brem S., and Brem H. Local treatment of malignant brain tumors using implantable chemotherapeutic polymers. J Natl Compr Canc Netw 3 (2005) 721-728
18. Bakhshi S., and North R.B. Implantable pumps for drug delivery to the brain. J Neurooncol 26 (1995) 133-139
19. Chandler W.F., Greenberg H.S., Ensminger W.D., et al. Use of implantable pump systems for intraarterial, intraventricular and intratumoral treatment of malignant brain tumors. Ann N Y Acad Sci 531 (1988) 206-212
20. Schantz E.J., and Lauffer M.A. Diffusion measurements in agar gel. Biochemistry 1 (1962) 658-663
21. Jain R.K. Transport of molecules in the tumor interstitium: a review. Cancer Res 47 (1987) 3039-3051
22. Jain R.K. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J Natl Cancer Inst 81 (1989) 570-576
23. Kroin J.S., and Penn R.D. Intracerebral chemotherapy: chronic microinfusion of cisplatin. Neurosurgery 10 (1982) 349-354
24. Sendelbeck S.L., and Urquhart J. Spatial distribution of dopamine, methotrexate and antipyrine during continuous intracerebral microperfusion. Brain Res 328 (1985) 251-258
25. Morrison P.F., and Dedrick R.L. Transport of cisplatin in rat brain following microinfusion: an analysis. J Pharm Sci 75 (1986) 120-128
26. Bobo R.H., Laske D.W., Akbasak A., Morrison P.F., Dedrick R.L., and Oldfield E.H. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A 91 (1994) 2076-2080
27. Degen J.W., Walbridge S., Vortmeyer A.O., Oldfield E.H., and Lonser R.R. Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats. J Neurosurg 99 (2003) 893-898
28. Krauze M.T., Forsayeth J., Park J.W., and Bankiewicz K.S. Real-time imaging and quantification of brain delivery of liposomes. Pharm Res 23 (2006) 2493-2504
29. Kioi M., Husain S.R., Croteau D., Kunwar S., and Puri R.K. Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy. Technol Cancer Res Treat 5 (2006) 239-250
30. Papagiannis P., Karaiskos P., Kozicki M., et al. Three-dimensional dose verification of the clinical application of gamma knife stereotactic radiosurgery using polymer gel and MRI. Phys Med Biol 50 (2005) 1979-1990
31. Sampson J.H., Raghavan R., Brady M.L., et al. Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions. Neuro Oncol 9 (2007) 343-353
32. Sampson J.H., Brady M.L., Petry N.A., et al. Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effect of target anatomy and catheter positioning. Neurosurgery 60 2 Suppl 1 (2007) 89-98
33. Lonser R.R., Warren K.E., Butman J.A., et al. Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note. J Neurosurg 107 (2007) 190-197
34. Noble C.O., Krauze M.T., Drummond D.C., et al. Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy. Cancer Res 66 (2006) 2801-2806
35. Kunwar S., Chang S.M., Prados M.D., et al. Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies. Neurosurg Focus 20 (2006) E15
36. Lang A.E., Gill S., Patel N.K., et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol 59 (2006) 459-466
37. Saito R., Krauze M.T., Bringas J.R., et al. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol 196 (2005) 381-389
38. Hadaczek P., Mirek H., Tamas L., et al. Perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther 14 (2006) 69-71
39. Hamilton J.F., Morrison P.F., Chen M.Y., et al. Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin. Exp Neurol 168 (2001) 155-161
40. Krauze M.T., Saito R., Noble C., et al. Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. J Neurosurg 103 (2005) 923-929
41. Lonser R.R., Walbridge S., Garmestani K., et al. Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion. J Neurosurg 97 (2002) 905-913
42. Morrison P.F., Chen M.Y., Chadwick R.S., Lonser R.R., and Oldfield E.H. Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics. Am J Physiol 277 (1999) 1218-1229
43. Mardor Y., Rahav O., Zauberman Y., et al. Convection-enhanced drug delivery: increased efficacy and magnetic resonance image monitoring. Cancer Res 65 (2005) 6858-6863
44. Saito R., Bringas J.R., McKnight T.R., et al. Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res 64 (2004) 2572-2579