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Volumn 7, Issue 11, 2007, Pages 1643-1650

Biological agents in head and neck cancer

Author keywords

Biological agents; Clinical trials; Head and neck cancer; Molecular basis

Indexed keywords

ANTINEOPLASTIC AGENT; AXITINIB; B RAF KINASE; BEVACIZUMAB; BORTEZOMIB; CAPECITABINE; CARBOPLATIN; CELECOXIB; CETUXIMAB; CISPLATIN; DACARBAZINE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; FLUOROURACIL; GEFITINIB; IMATINIB; LAPATINIB; METHOTREXATE; N (3,3 DIMETHYL 6 INDOLINYL) 2 (4 PYRIDINYLMETHYLAMINO)NICOTINAMIDE; PACLITAXEL; PLACEBO; PROTEIN P53; PROTEIN RET; SORAFENIB; TRASTUZUMAB; UNINDEXED DRUG; VANDETANIB; VIRUS DNA;

EID: 37349077937     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.7.11.1643     Document Type: Review
Times cited : (6)

References (94)
  • 1
    • 0033969549 scopus 로고    scopus 로고
    • p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck
    • Temam S, Flahault A, Perie S et al. p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck. J. Clin. Oncol. 18, 385-394 (2000).
    • (2000) J. Clin. Oncol , vol.18 , pp. 385-394
    • Temam, S.1    Flahault, A.2    Perie, S.3
  • 2
    • 0034086197 scopus 로고    scopus 로고
    • p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: A prospective series
    • Cabelguenne A, Blons H, de Waziers I et al. p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series. J. Clin. Oncol. 18, 1465-1473 (2000).
    • (2000) J. Clin. Oncol , vol.18 , pp. 1465-1473
    • Cabelguenne, A.1    Blons, H.2    de Waziers, I.3
  • 3
    • 0031059355 scopus 로고    scopus 로고
    • Markers of radioresistance in squamous cell carcinomas of the head and neck: A clinicopathologic and immunohistochemical study
    • Raybaud-Diogene H, Fortin A, Morency R et al. Markers of radioresistance in squamous cell carcinomas of the head and neck: a clinicopathologic and immunohistochemical study. J. Clin. Oncol. 15, 1038 (1997).
    • (1997) J. Clin. Oncol , vol.15 , pp. 1038
    • Raybaud-Diogene, H.1    Fortin, A.2    Morency, R.3
  • 4
    • 0036468788 scopus 로고    scopus 로고
    • p53 and Ki-67 as markers of radioresistance in head and neck carcinoma
    • Couture C, Raybaud-Diogene H, Tetu B et al. p53 and Ki-67 as markers of radioresistance in head and neck carcinoma. Cancer 94, 713-722 (2002).
    • (2002) Cancer , vol.94 , pp. 713-722
    • Couture, C.1    Raybaud-Diogene, H.2    Tetu, B.3
  • 5
    • 0346645692 scopus 로고    scopus 로고
    • The role of epidermal growth factor receptor in head and neck squamous cell carcinoma
    • Pomerantz RG, Grandis JR. The role of epidermal growth factor receptor in head and neck squamous cell carcinoma. Curr. Oncol. Rep. 5, 140-146 (2003).
    • (2003) Curr. Oncol. Rep , vol.5 , pp. 140-146
    • Pomerantz, R.G.1    Grandis, J.R.2
  • 6
    • 1842471336 scopus 로고    scopus 로고
    • Signaling through the epidermal growth factor receptor during the development of malignancy
    • Grandis JR, Sok JC. Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol. Ther. 102, 37-46 (2004).
    • (2004) Pharmacol. Ther , vol.102 , pp. 37-46
    • Grandis, J.R.1    Sok, J.C.2
  • 7
    • 0032478998 scopus 로고    scopus 로고
    • Levels of TGF-α and EGFR protein in head and neck squamous cell carcinoma and patient survival
    • Grandis JR, Melhem MF, Gooding WE et al. Levels of TGF-α and EGFR protein in head and neck squamous cell carcinoma and patient survival. J. Natl Cancer Inst. 90, 824-832 (1998).
    • (1998) J. Natl Cancer Inst , vol.90 , pp. 824-832
    • Grandis, J.R.1    Melhem, M.F.2    Gooding, W.E.3
  • 8
    • 0037115674 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    • Ang KK, Berkey BA, Tu X et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res. 62, 7350-7356 (2002).
    • (2002) Cancer Res , vol.62 , pp. 7350-7356
    • Ang, K.K.1    Berkey, B.A.2    Tu, X.3
  • 9
    • 0942300638 scopus 로고    scopus 로고
    • The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck
    • Eriksen JG, Steiniche T, Askaa J, Alsner J, Overgaard J. The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 58, 561-566 (2004).
    • (2004) Int. J. Radiat. Oncol. Biol. Phys , vol.58 , pp. 561-566
    • Eriksen, J.G.1    Steiniche, T.2    Askaa, J.3    Alsner, J.4    Overgaard, J.5
  • 10
    • 24944479590 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial
    • Bentzen SM, Atasoy BM, Daley FM et al. Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial. J. Clin. Oncol. 23, 5560-5567 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 5560-5567
    • Bentzen, S.M.1    Atasoy, B.M.2    Daley, F.M.3
  • 11
    • 20244389231 scopus 로고    scopus 로고
    • Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck
    • Lee JW, Soung YH, Kim SY et al. Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin. Cancer Res. 11, 2879-2882 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 2879-2882
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 12
    • 0037444269 scopus 로고    scopus 로고
    • Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma
    • Freier K, Joos S, Flechtenmacher C et al. Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res. 63, 1179-1182 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1179-1182
    • Freier, K.1    Joos, S.2    Flechtenmacher, C.3
  • 13
    • 23044482678 scopus 로고    scopus 로고
    • Epidermal growth factor receptor - its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas
    • Mrhalova M, Plzak J, Betka J, Kodet R. Epidermal growth factor receptor - its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas. Neoplasma 52, 338-343 (2005).
    • (2005) Neoplasma , vol.52 , pp. 338-343
    • Mrhalova, M.1    Plzak, J.2    Betka, J.3    Kodet, R.4
  • 14
    • 10944250660 scopus 로고    scopus 로고
    • Genomic gain of the epidermal growth factor receptor harboring band 7p12 is part of a complex pattern of genomic imbalances in oral squamous cell carcinomas
    • Gebhart E, Ries J, Wiltfang J, Liehr T, Efferth T. Genomic gain of the epidermal growth factor receptor harboring band 7p12 is part of a complex pattern of genomic imbalances in oral squamous cell carcinomas. Arch. Med. Res. 35, 385-394 (2004).
    • (2004) Arch. Med. Res , vol.35 , pp. 385-394
    • Gebhart, E.1    Ries, J.2    Wiltfang, J.3    Liehr, T.4    Efferth, T.5
  • 15
    • 33748653109 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
    • Chung CH, Ely K, McGavran L et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J. Clin. Oncol. 24, 4170-4176 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 4170-4176
    • Chung, C.H.1    Ely, K.2    McGavran, L.3
  • 16
    • 33846260178 scopus 로고    scopus 로고
    • Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma
    • Thomas SM, Bhola NE, Zhang Q et al. Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. Cancer Res. 66, 11831-11839 (2006).
    • (2006) Cancer Res , vol.66 , pp. 11831-11839
    • Thomas, S.M.1    Bhola, N.E.2    Zhang, Q.3
  • 17
    • 33846696437 scopus 로고    scopus 로고
    • A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo
    • Rajput A, Koterba AP, Kreisberg JI et al. A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. Cancer Res. 67, 665-673 (2007).
    • (2007) Cancer Res , vol.67 , pp. 665-673
    • Rajput, A.1    Koterba, A.P.2    Kreisberg, J.I.3
  • 18
    • 0035097541 scopus 로고    scopus 로고
    • Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis
    • Gallo O, Franchi A, Magnelli L et al. Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. Neoplasia 3, 53-61 (2001).
    • (2001) Neoplasia , vol.3 , pp. 53-61
    • Gallo, O.1    Franchi, A.2    Magnelli, L.3
  • 19
    • 33645499486 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms
    • Pore N, Jiang Z, Gupta A et al. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Res. 66, 3197-3204 (2006).
    • (2006) Cancer Res , vol.66 , pp. 3197-3204
    • Pore, N.1    Jiang, Z.2    Gupta, A.3
  • 20
    • 0033816699 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinomas
    • Mineta H, Miura K, Ogino T et al. Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinomas. Br. J. Cancer 83, 775-781 (2000).
    • (2000) Br. J. Cancer , vol.83 , pp. 775-781
    • Mineta, H.1    Miura, K.2    Ogino, T.3
  • 21
    • 33644849887 scopus 로고    scopus 로고
    • Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 α and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
    • Koukourakis MI, Bentzen SM, Giatromanolaki A et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 α and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J. Clin. Oncol. 24, 727-735 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 727-735
    • Koukourakis, M.I.1    Bentzen, S.M.2    Giatromanolaki, A.3
  • 22
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • Sridhar SS, Hedley D. Siu LL. Raf kinase as a target for anticancer therapeutics. Mol. Cancer Ther. 4, 677-685 (2005).
    • (2005) Mol. Cancer Ther , vol.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 23
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 354, 567-578 (2006).
    • (2006) N. Engl. J. Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 24
    • 33749639526 scopus 로고    scopus 로고
    • EGFR expression and clinical outcome in head and neck patients treated with radiotherapy with or without cetuximab
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Bonner JA, Harari PM, Giralt J et al. EGFR expression and clinical outcome in head and neck patients treated with radiotherapy with or without cetuximab. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 25
    • 33644971314 scopus 로고    scopus 로고
    • Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: A pilot Phase II study of a new combined-modality paradigm
    • Pfister DG, Su YB, Kraus DH et al. Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: a pilot Phase II study of a new combined-modality paradigm. J. Clin. Oncol. 24, 1072-1078 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 1072-1078
    • Pfister, D.G.1    Su, Y.B.2    Kraus, D.H.3
  • 26
    • 47349101706 scopus 로고    scopus 로고
    • Cetuximab (C-mab) and chemo-radiation (CT-RT) for loco-regional advanced squamous cell carcinoma of the head and neck (HNC): A Phase II study
    • Presented at:, Chicago, IL, USA, June 1-5
    • Merlano M, Numico G, Russi EG et al. Cetuximab (C-mab) and chemo-radiation (CT-RT) for loco-regional advanced squamous cell carcinoma of the head and neck (HNC): a Phase II study. Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Merlano, M.1    Numico, G.2    Russi, E.G.3
  • 27
    • 34147140250 scopus 로고    scopus 로고
    • Induction chemotherapy (CT) with weekly paclitaxel, carboplatin, and cetuximab for squamous cell carcinoma of the head and neck (HN)
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Kies MS, Garden AS, Holsinger C et al. Induction chemotherapy (CT) with weekly paclitaxel, carboplatin, and cetuximab for squamous cell carcinoma of the head and neck (HN). Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Kies, M.S.1    Garden, A.S.2    Holsinger, C.3
  • 28
    • 33747867158 scopus 로고    scopus 로고
    • Induction chemotherapy + gefitinib followed by concurrent chemotherapy/radiation therapy/ gefitinib for patients (pts) with locally advanced squamous carcinoma of the head and neck: A Phase I/II trial of the Minnie Pearl Cancer Research Network
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Doss HH, Greco FA, Meluch AA et al. Induction chemotherapy + gefitinib followed by concurrent chemotherapy/radiation therapy/ gefitinib for patients (pts) with locally advanced squamous carcinoma of the head and neck: a Phase I/II trial of the Minnie Pearl Cancer Research Network. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Doss, H.H.1    Greco, F.A.2    Meluch, A.A.3
  • 29
    • 33846841515 scopus 로고    scopus 로고
    • Phase I study of the EGFR tyrosine kinase inhibitor erlotinib in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN)
    • Presented at:, Atlanta, CA, USA, June 2-6
    • Savvides P, Agarwala SS, Greskovich J et al. Phase I study of the EGFR tyrosine kinase inhibitor erlotinib in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN). Presented at: 42nd ASCO Annual Meeting. Atlanta, CA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Savvides, P.1    Agarwala, S.S.2    Greskovich, J.3
  • 30
    • 37349058867 scopus 로고    scopus 로고
    • Phase II study of erlotinib combined with cisplatin and radiotherapy for locally advanced squamous cell carcinoma of the head and neck (SCCHN)
    • Presented at:, Chicago, IL, USA, June 1-5
    • Herchenhorn D, Dias FL, Pineda RM et al. Phase II study of erlotinib combined with cisplatin and radiotherapy for locally advanced squamous cell carcinoma of the head and neck (SCCHN). Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Herchenhorn, D.1    Dias, F.L.2    Pineda, R.M.3
  • 31
    • 37348998501 scopus 로고    scopus 로고
    • Updated results of a Phase II trial integrating gefitinib (G) into concurrent chemoradiation (CRT) followed by G adjuvant therapy for locally advanced head and neck cancer (HNC)
    • Presented at:, Chicago, IL, USA, June 1-5
    • Ahmed SM, Cohen EE, Haraf DJ et al. Updated results of a Phase II trial integrating gefitinib (G) into concurrent chemoradiation (CRT) followed by G adjuvant therapy for locally advanced head and neck cancer (HNC). Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Ahmed, S.M.1    Cohen, E.E.2    Haraf, D.J.3
  • 32
    • 34147155082 scopus 로고    scopus 로고
    • A Phase I, open-label study (EGF100262) of lapatinib plus chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN)
    • Bourhis J, Harrington K, Rosine D et al. A Phase I, open-label study (EGF100262) of lapatinib plus chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). Ann. Oncol. 17(Suppl. 9) (2006).
    • (2006) Ann. Oncol , vol.17 , Issue.SUPPL. 9
    • Bourhis, J.1    Harrington, K.2    Rosine, D.3
  • 33
    • 37349080161 scopus 로고    scopus 로고
    • Gefitinib plus concomitant boost accelerated radiation (AFX-CB) and concurrent weekly cisplatin for locally advanced unresectable squamous cell head and neck carcinomas (SCCHN): A Phase II study
    • Presented at:, Chicago, IL, USA, June 1-5
    • Rueda A, Medina JA, Mesia R et al. Gefitinib plus concomitant boost accelerated radiation (AFX-CB) and concurrent weekly cisplatin for locally advanced unresectable squamous cell head and neck carcinomas (SCCHN): a Phase II study. Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Rueda, A.1    Medina, J.A.2    Mesia, R.3
  • 34
    • 37349006137 scopus 로고    scopus 로고
    • Radiosensitization with a COX2 inhibitor with chemoradiation for head and neck cancer
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Prellop P, Peters G, Carroll W et al. Radiosensitization with a COX2 inhibitor with chemoradiation for head and neck cancer. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Prellop, P.1    Peters, G.2    Carroll, W.3
  • 35
    • 33748643451 scopus 로고    scopus 로고
    • A Phase I study of bevacizumab (B) with fluorouracil (F) and hydroxyurea (H) with concomitant radiotherapy (X) (B-FHX) for poor prognosis head and neck cancer (HNC)
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Seiwert TY, Haraf DJ, Cohen EE et al. A Phase I study of bevacizumab (B) with fluorouracil (F) and hydroxyurea (H) with concomitant radiotherapy (X) (B-FHX) for poor prognosis head and neck cancer (HNC). Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Seiwert, T.Y.1    Haraf, D.J.2    Cohen, E.E.3
  • 36
    • 37349037831 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN)
    • Presented at:, Chicago, IL, USA, June 1-5
    • Savvides P, Greskovich J, Bokar J et al. Phase II study of bevacizumab in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN). Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Savvides, P.1    Greskovich, J.2    Bokar, J.3
  • 37
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
    • Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J. Clin. Oncol. 23, 8646-8654 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 38
    • 36048934209 scopus 로고    scopus 로고
    • Cetuximab extends survival of patients with recurrent or metastatic SCCHN when added to first line platinum based therapy - Results of a randomized Phase III (Extreme) study
    • Presented at:, Chicago, IL, USA, June 1-5
    • Vermorken J, Mesia R, Vega V et al. Cetuximab extends survival of patients with recurrent or metastatic SCCHN when added to first line platinum based therapy - Results of a randomized Phase III (Extreme) study Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Vermorken, J.1    Mesia, R.2    Vega, V.3
  • 39
    • 41949121745 scopus 로고    scopus 로고
    • Phase II study of combination cetuximab and weekly paclitaxel in patients with metastatic/ recurrent squamous cell carcinoma of head and neck (SCCHN): Spanish Head and Neck Cancer Group (TTCC)
    • Presented at:, Chicago, IL, USA, June 1-5
    • Hitt R, Irigoyen A, Nuñez J et al. Phase II study of combination cetuximab and weekly paclitaxel in patients with metastatic/ recurrent squamous cell carcinoma of head and neck (SCCHN): Spanish Head and Neck Cancer Group (TTCC). Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Hitt, R.1    Irigoyen, A.2    Nuñez, J.3
  • 40
    • 23844523253 scopus 로고    scopus 로고
    • Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck
    • Baselga J, Trigo JM, Bourhis J et al. Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck. J. Clin. Oncol. 23, 5568-5577 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 5568-5577
    • Baselga, J.1    Trigo, J.M.2    Bourhis, J.3
  • 41
    • 24944490558 scopus 로고    scopus 로고
    • Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck
    • Herbst RS, Arquette M, Shin DM et al. Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck. J. Clin. Oncol. 23, 5578-5587 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 5578-5587
    • Herbst, R.S.1    Arquette, M.2    Shin, D.M.3
  • 42
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter Phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • Vermorken JB, Trigo J, Hitt R et al. Open-label, uncontrolled, multicenter Phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J. Clin. Oncol. 25, 2171-2177 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3
  • 43
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Rosen F, Stadler WM et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J. Clin. Oncol. 21, 1980-1987 (2003).
    • (2003) J. Clin. Oncol , vol.21 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3
  • 44
    • 34250844262 scopus 로고    scopus 로고
    • Phase II study of gefitinib in patients with metastatic/recurrent squamous cell carcinoma of the skin
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Glisson B, Kim ES, Kies MS et al. Phase II study of gefitinib in patients with metastatic/recurrent squamous cell carcinoma of the skin. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Glisson, B.1    Kim, E.S.2    Kies, M.S.3
  • 45
    • 28544432807 scopus 로고    scopus 로고
    • Phase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Kane MA, List MA et al. Phase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Clin. Cancer Res. 11, 8418-8424 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 8418-8424
    • Cohen, E.E.1    Kane, M.A.2    List, M.A.3
  • 46
    • 34347395051 scopus 로고    scopus 로고
    • A Phase III randomized parallel-group study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck
    • Presented at:, Los Angeles, CA, USA, April 14-18
    • Stewart JS, Cohen EE, Licitra L et al. A Phase III randomized parallel-group study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck. Presented at: AACR Annual Meeting. Los Angeles, CA, USA, April 14-18 2007.
    • (2007) AACR Annual Meeting
    • Stewart, J.S.1    Cohen, E.E.2    Licitra, L.3
  • 47
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE et al. Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J. Clin. Oncol. 22, 77-85 (2004).
    • (2004) J. Clin. Oncol , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3
  • 48
    • 34250208469 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: A Princess Margaret Hospital Phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study
    • Siu LL, Soulieres D, Chen EX et al. Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Princess Margaret Hospital Phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study. J. Clin. Oncol. 25, 2178-2183 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 2178-2183
    • Siu, L.L.1    Soulieres, D.2    Chen, E.X.3
  • 49
    • 41949113428 scopus 로고    scopus 로고
    • Final results of a Phase II study of erlotinib, docetaxel and cisplatin in patients with recurrent/ metastatic head and neck cancer
    • Presented at:, Chicago, IL, USA, June 1-5
    • Kim ES, Kies MS, Glisson BS et al. Final results of a Phase II study of erlotinib, docetaxel and cisplatin in patients with recurrent/ metastatic head and neck cancer. Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Kim, E.S.1    Kies, M.S.2    Glisson, B.S.3
  • 50
    • 37349075386 scopus 로고    scopus 로고
    • Preliminary results of a Phase II study to evaluate gefitinib combined with docetaxel and cisplatin in patients with recurrent and/or metastatic squamous-cell carcinoma of the head and neck
    • Presented at:, Orlando, FL, USA, May 13-17
    • Belón J, Irigoyen A, Rodríguez I et al. Preliminary results of a Phase II study to evaluate gefitinib combined with docetaxel and cisplatin in patients with recurrent and/or metastatic squamous-cell carcinoma of the head and neck. Presented at: 41st ASCO Annual Meeting. Orlando, FL, USA, May 13-17 2005.
    • (2005) 41st ASCO Annual Meeting
    • Belón, J.1    Irigoyen, A.2    Rodríguez, I.3
  • 51
    • 27244432279 scopus 로고    scopus 로고
    • Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Wirth LJ, Haddad RI, Lindeman NI et al. Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck. J. Clin. Oncol. 23, 6976-6981 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 6976-6981
    • Wirth, L.J.1    Haddad, R.I.2    Lindeman, N.I.3
  • 52
    • 37349105632 scopus 로고    scopus 로고
    • A Phase I study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck (HNC)
    • Presented at:, Orlando, FL, USA, May 13-17
    • Vokes EE, Cohen EE, Mauer AM et al. A Phase I study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck (HNC). Presented at: 41st ASCO Annual Meeting. Orlando, FL, USA, May 13-17 2005.
    • (2005) 41st ASCO Annual Meeting
    • Vokes, E.E.1    Cohen, E.E.2    Mauer, A.M.3
  • 53
    • 36048978575 scopus 로고    scopus 로고
    • A Phase II trial of BAY 43-9006 in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC): A Southwest Oncology Group (SWOG) trial
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Williamson SK, Moon J, Huang CH et al. A Phase II trial of BAY 43-9006 in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC): a Southwest Oncology Group (SWOG) trial. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Williamson, S.K.1    Moon, J.2    Huang, C.H.3
  • 54
    • 37349129214 scopus 로고    scopus 로고
    • Phase II study of lapatinib (GW572016) in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN)
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Abidoye OO, Cohen EE, Wong SJ et al. Phase II study of lapatinib (GW572016) in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Abidoye, O.O.1    Cohen, E.E.2    Wong, S.J.3
  • 55
    • 33846144441 scopus 로고    scopus 로고
    • Microenvironmental genomic alterations and clinicopathological behavior in head and neck squamous cell carcinoma
    • Weber F, Xu Y, Zhang L et al. Microenvironmental genomic alterations and clinicopathological behavior in head and neck squamous cell carcinoma. JAMA 297, 187-195 (2007).
    • (2007) JAMA , vol.297 , pp. 187-195
    • Weber, F.1    Xu, Y.2    Zhang, L.3
  • 56
    • 33750338001 scopus 로고    scopus 로고
    • Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer
    • Yip KW, Shi W, Pintilie M et al. Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer. Clin. Cancer Res. 12, 5726-5732 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 5726-5732
    • Yip, K.W.1    Shi, W.2    Pintilie, M.3
  • 57
    • 10744230953 scopus 로고    scopus 로고
    • Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma - a prospective study
    • Ma BB, Poon TC, To KF et al. Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma - a prospective study. Head Neck 25, 864-872 (2003).
    • (2003) Head Neck , vol.25 , pp. 864-872
    • Ma, B.B.1    Poon, T.C.2    To, K.F.3
  • 58
    • 4644345181 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy
    • Chua DT, Nicholls JM, Sham JS, Au GK. Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 59, 11-20 (2004).
    • (2004) Int. J. Radiat. Oncol. Biol. Phys , vol.59 , pp. 11-20
    • Chua, D.T.1    Nicholls, J.M.2    Sham, J.S.3    Au, G.K.4
  • 59
    • 6944243898 scopus 로고    scopus 로고
    • p53 overexpression in nasopharyngeal carcinoma
    • Agaoglu PY, Dizdar Y, Dogan O et al. p53 overexpression in nasopharyngeal carcinoma. In Vivo 18, 555-560 (2004).
    • (2004) In Vivo , vol.18 , pp. 555-560
    • Agaoglu, P.Y.1    Dizdar, Y.2    Dogan, O.3
  • 60
    • 20644435370 scopus 로고    scopus 로고
    • Multicenter, Phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma
    • Chan AT, Hsu MM, Goh BC et al. Multicenter, Phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma. J. Clin. Oncol. 23, 3568-3576 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 3568-3576
    • Chan, A.T.1    Hsu, M.M.2    Goh, B.C.3
  • 61
    • 20144365643 scopus 로고    scopus 로고
    • Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes
    • Straathof KC, Bollard CM, Popat U et al. Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes. Blood 105, 1898-1904 (2005).
    • (2005) Blood , vol.105 , pp. 1898-1904
    • Straathof, K.C.1    Bollard, C.M.2    Popat, U.3
  • 62
    • 33644788176 scopus 로고    scopus 로고
    • Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    • Comoli P, Pedrazzoli P, Maccario R et al. Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes. J. Clin. Oncol. 23, 8942-8949 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 8942-8949
    • Comoli, P.1    Pedrazzoli, P.2    Maccario, R.3
  • 63
    • 0032873349 scopus 로고    scopus 로고
    • KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma
    • Holst VA, Marshall CE, Moskaluk CA, Frierson HF Jr. KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod. Pathol. 12, 956-960 (1999).
    • (1999) Mod. Pathol , vol.12 , pp. 956-960
    • Holst, V.A.1    Marshall, C.E.2    Moskaluk, C.A.3    Frierson Jr., H.F.4
  • 64
    • 0034213697 scopus 로고    scopus 로고
    • Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma
    • Jeng YM, Lin CY, Hsu HC. Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma. Cancer Lett. 154, 107-111 (2000).
    • (2000) Cancer Lett , vol.154 , pp. 107-111
    • Jeng, Y.M.1    Lin, C.Y.2    Hsu, H.C.3
  • 65
    • 37349104897 scopus 로고    scopus 로고
    • Treatment relevant immunophenotyping of 139 salivary gland carcinomas (SGCs)
    • In Press
    • Locati LD, Perrone F, Losa M et al. Treatment relevant immunophenotyping of 139 salivary gland carcinomas (SGCs). Ann. Oncol. (2007) (In Press).
    • (2007) Ann. Oncol
    • Locati, L.D.1    Perrone, F.2    Losa, M.3
  • 66
    • 20044384866 scopus 로고    scopus 로고
    • Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: A Princess Margaret Hospital Phase II consortium study
    • Hotte SJ, Winquist EW, Lamont E et al. Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital Phase II consortium study. J. Clin. Oncol. 23, 585-590 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 585-590
    • Hotte, S.J.1    Winquist, E.W.2    Lamont, E.3
  • 67
    • 33846557908 scopus 로고    scopus 로고
    • A Phase II study of imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands
    • Pfeffer MR, Talmi Y, Catane R et al. A Phase II study of imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands. Oral Oncol. 43, 33-36 (2007).
    • (2007) Oral Oncol , vol.43 , pp. 33-36
    • Pfeffer, M.R.1    Talmi, Y.2    Catane, R.3
  • 68
    • 4344564244 scopus 로고    scopus 로고
    • Imatinib mesylate as treatment for adenoid cystic carcinoma of the salivary glands: Report of two successfully treated cases
    • Alcedo JC, Fabrega JM, Arosemena JR, Urrutia A. Imatinib mesylate as treatment for adenoid cystic carcinoma of the salivary glands: report of two successfully treated cases. Head Neck 26, 829-831 (2004).
    • (2004) Head Neck , vol.26 , pp. 829-831
    • Alcedo, J.C.1    Fabrega, J.M.2    Arosemena, J.R.3    Urrutia, A.4
  • 69
    • 24944587262 scopus 로고    scopus 로고
    • Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands
    • Faivre S, Raymond E, Casiraghi O, Temam S, Berthaud P. Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands. J. Clin. Oncol. 23, 6271-6273 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 6271-6273
    • Faivre, S.1    Raymond, E.2    Casiraghi, O.3    Temam, S.4    Berthaud, P.5
  • 70
    • 10744227930 scopus 로고    scopus 로고
    • HER2 expression in salivary gland carcinomas: Dependence on histological subtype
    • Glisson B, Colevas AD, Haddad R et al. HER2 expression in salivary gland carcinomas: dependence on histological subtype. Clin. Cancer Res. 10, 944-946 (2004).
    • (2004) Clin. Cancer Res , vol.10 , pp. 944-946
    • Glisson, B.1    Colevas, A.D.2    Haddad, R.3
  • 71
    • 0042703590 scopus 로고    scopus 로고
    • Herceptin in patients with advanced or metastatic salivary gland carcinomas. A Phase II study
    • Haddad R, Colevas AD, Krane JF et al. Herceptin in patients with advanced or metastatic salivary gland carcinomas. A Phase II study. Oral Oncol. 39, 724-727 (2003).
    • (2003) Oral Oncol , vol.39 , pp. 724-727
    • Haddad, R.1    Colevas, A.D.2    Krane, J.F.3
  • 72
    • 33646704640 scopus 로고    scopus 로고
    • Phase II trial of gefitinib in patients with incurable salivary gland cancer
    • Presented at:, Orlando, FL, USA, May 13-17
    • Glisson BS, Blumenschein G, Francisco M et al. Phase II trial of gefitinib in patients with incurable salivary gland cancer. Presented at: 41st ASCO Annual Meeting. Orlando, FL, USA, May 13-17 2005.
    • (2005) 41st ASCO Annual Meeting
    • Glisson, B.S.1    Blumenschein, G.2    Francisco, M.3
  • 73
    • 33846662788 scopus 로고    scopus 로고
    • Cetuximab (C225) in recurrent and/or metastatic salivary gland carcinomas (RMSGCs): A monoinstitutional Phase II study
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Licitra L, Locati LD, Potepan P et al. Cetuximab (C225) in recurrent and/or metastatic salivary gland carcinomas (RMSGCs): A monoinstitutional Phase II study. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Licitra, L.1    Locati, L.D.2    Potepan, P.3
  • 74
    • 33846699635 scopus 로고    scopus 로고
    • A multicenter Phase II study of lapatinib in recurrent or metastatic adenoid cystic (ACC) and non-ACC malignant tumors of the salivary glands (MSGT)
    • Agulnik M, Cohen EE, Cohen RB et al. A multicenter Phase II study of lapatinib in recurrent or metastatic adenoid cystic (ACC) and non-ACC malignant tumors of the salivary glands (MSGT). Ann. Oncol. 17(Suppl. 9), ix179 (2006).
    • (2006) Ann. Oncol , vol.17 , Issue.SUPPL. 9
    • Agulnik, M.1    Cohen, E.E.2    Cohen, R.B.3
  • 75
    • 0041508613 scopus 로고    scopus 로고
    • A complete remission with androgen-deprivation therapy in a recurrent androgen receptor-expressing adenocarcinoma of the parotid gland
    • Locati LD, Quattrone P, Bossi P et al. A complete remission with androgen-deprivation therapy in a recurrent androgen receptor-expressing adenocarcinoma of the parotid gland. Ann. Oncol. 14, 1327-1328 (2003).
    • (2003) Ann. Oncol , vol.14 , pp. 1327-1328
    • Locati, L.D.1    Quattrone, P.2    Bossi, P.3
  • 76
  • 77
    • 9444277283 scopus 로고    scopus 로고
    • How thyroid tumors start and why it matters: Kinase mutants as targets for solid cancer pharmacotherapy
    • Fagin JA. How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy. J. Endocrinol. 183, 249-256 (2004).
    • (2004) J. Endocrinol , vol.183 , pp. 249-256
    • Fagin, J.A.1
  • 79
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M. BRAF mutation in thyroid cancer. Endocr. Relat. Cancer 12, 245-262 2005).
    • (2005) Endocr. Relat. Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 80
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan PT, Garnett MJ, Roe SM et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116, 855-867 (2004).
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3
  • 81
    • 10744222003 scopus 로고    scopus 로고
    • BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
    • Nikiforova MN, Kimura ET, Gandhi M et al. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J. Clin. Endocrinol. Metab. 88, 5399-5404 (2003).
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , pp. 5399-5404
    • Nikiforova, M.N.1    Kimura, E.T.2    Gandhi, M.3
  • 82
    • 28744442816 scopus 로고    scopus 로고
    • BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
    • Xing M, Westra WH, Tufano RP et al. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J. Clin. Endocrinol. Metab. 90, 6373-6379 (2005).
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 6373-6379
    • Xing, M.1    Westra, W.H.2    Tufano, R.P.3
  • 83
    • 20144387455 scopus 로고    scopus 로고
    • The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    • Melillo RM, Castellone MD, Guarino V et al. The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. J. Clin. Invest. 115, 1068-1081 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 1068-1081
    • Melillo, R.M.1    Castellone, M.D.2    Guarino, V.3
  • 84
    • 9844249675 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid
    • Soh EY, Duh QY, Sobhi SA et al. Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid. J. Clin. Endocrinol. Metabol. 82, 3741-3747 (1997).
    • (1997) J. Clin. Endocrinol. Metabol , vol.82 , pp. 3741-3747
    • Soh, E.Y.1    Duh, Q.Y.2    Sobhi, S.A.3
  • 85
    • 33846647957 scopus 로고    scopus 로고
    • Anaplastic thyroid carcinoma: Expression profile of targets for therapy offers new insights for disease treatment
    • Wiseman SM, Masoudi H, Niblock P et al. Anaplastic thyroid carcinoma: expression profile of targets for therapy offers new insights for disease treatment. Ann. Surg. Oncol. 14, 719-729 (2007).
    • (2007) Ann. Surg. Oncol , vol.14 , pp. 719-729
    • Wiseman, S.M.1    Masoudi, H.2    Niblock, P.3
  • 86
    • 34547776916 scopus 로고    scopus 로고
    • Epidermal growth factor receptor status in anaplastic thyroid carcinoma
    • Lee DH, Lee GK, Kong SY et al. Epidermal growth factor receptor status in anaplastic thyroid carcinoma. J. Clin. Pathol. 60, 881-884 (2007).
    • (2007) J. Clin. Pathol , vol.60 , pp. 881-884
    • Lee, D.H.1    Lee, G.K.2    Kong, S.Y.3
  • 87
    • 37349054645 scopus 로고    scopus 로고
    • A Phase II trial of PS-341 (bortezomib) followed by the addition of doxorubicin at progression in incurable adenoid cystic carcinoma of the head and neck: An Eastern Cooperative Oncology Group study
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Argiris A, Goldwasser MA, Burtness B et al. A Phase II trial of PS-341 (bortezomib) followed by the addition of doxorubicin at progression in incurable adenoid cystic carcinoma of the head and neck: an Eastern Cooperative Oncology Group study. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Argiris, A.1    Goldwasser, M.A.2    Burtness, B.3
  • 88
    • 37349058866 scopus 로고    scopus 로고
    • Phase-2 study of imatinib in metastasized medullary thyroid carcinoma
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Zonnenberg BA, Links T, Quarles van Uffort P et al. Phase-2 study of imatinib in metastasized medullary thyroid carcinoma. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Zonnenberg, B.A.1    Links, T.2    Quarles van Uffort, P.3
  • 89
    • 37349087449 scopus 로고    scopus 로고
    • Phase I/II trial of capecitabine (C), dacarbazine (D) and imatinib (I) (CDI) for patients (pts) metastatic medullary thyroid cancer (MTC)
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Hoff PM, Hoff AO, Phan A et al. Phase I/II trial of capecitabine (C), dacarbazine (D) and imatinib (I) (CDI) for patients (pts) metastatic medullary thyroid cancer (MTC). Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Hoff, P.M.1    Hoff, A.O.2    Phan, A.3
  • 90
    • 37349029664 scopus 로고    scopus 로고
    • Initial results from a Phase II trial of motesanib diphosphate (AMG 706) in patients with differentiated thyroid cancer (DTC)
    • Presented at:, Chicago, IL, USA, June 1-5
    • Sherman SI, Schlumberger MJ, Droz J et al. Initial results from a Phase II trial of motesanib diphosphate (AMG 706) in patients with differentiated thyroid cancer (DTC). Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Sherman, S.I.1    Schlumberger, M.J.2    Droz, J.3
  • 91
    • 33749259546 scopus 로고    scopus 로고
    • Significant clinical and biologic activity of RAF/VEGF-R kinase inhibitor BAY 43-9006 in patients with metastatic papillary thyroid carcinoma (PTC): Updated results of a Phase II study
    • Presented at:, Atlanta, GA, USA, June 2-6
    • Kloos R, Ringel M, Knopp M et al. Significant clinical and biologic activity of RAF/VEGF-R kinase inhibitor BAY 43-9006 in patients with metastatic papillary thyroid carcinoma (PTC): updated results of a Phase II study. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA, June 2-6 2006.
    • (2006) 42nd ASCO Annual Meeting
    • Kloos, R.1    Ringel, M.2    Knopp, M.3
  • 92
    • 40849118632 scopus 로고    scopus 로고
    • Vandetanib in metastatic hereditary medullary thyroid cancer: Follow-up results of an open-label Phase II trial
    • Presented at:, Chicago, IL, USA, June 1-5
    • Wells SA, Gosnell JE, Gagei RF et al. Vandetanib in metastatic hereditary medullary thyroid cancer: follow-up results of an open-label Phase II trial. Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Wells, S.A.1    Gosnell, J.E.2    Gagei, R.F.3
  • 93
    • 79251487431 scopus 로고    scopus 로고
    • A Phase II study of gefitinib in patients with advanced thyroid cancer
    • Presented at:, Chicago, IL, USA, June 1-5
    • Pennell NA, Daniels GH, Haddad RI et al. A Phase II study of gefitinib in patients with advanced thyroid cancer. Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Pennell, N.A.1    Daniels, G.H.2    Haddad, R.I.3
  • 94
    • 84858504354 scopus 로고    scopus 로고
    • A Phase II study of axitinib (AG-013736 [AG]) in patients (pts) with advanced thyroid cancers
    • Presented at:, Chicago, IL, USA, June 1-5
    • Cohen EE, Vokes EE, Rosen LS et al. A Phase II study of axitinib (AG-013736 [AG]) in patients (pts) with advanced thyroid cancers. Presented at: 43rd ASCO Annual Meeting. Chicago, IL, USA, June 1-5 2007.
    • (2007) 43rd ASCO Annual Meeting
    • Cohen, E.E.1    Vokes, E.E.2    Rosen, L.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.