Altered mammary gland development in the p53+/m mouse, a model of accelerated aging

Developmental Biology

Volumn 313, Issue 1, 2008, Pages 130-141

  Gatza, Catherine E ^a   Dumble, Melissa ^a   Kittrell, Frances ^a   Edwards, David G ^a   Dearth, Robert K ^a   Lee, Adrian V ^a   Xu, Jianming ^a   Medina, Daniel ^a   Donehower, Lawrence A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Ductal morphogenesis; IGF 1; Mammary gland; Mouse; p53

Indexed keywords

ESTROGEN; PROGESTERONE; PROTEIN P53; SOMATOMEDIN C;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST DEVELOPMENT; BREAST EPITHELIUM; CONTROLLED STUDY; DISEASE RESISTANCE; FEMALE; GENE DOSAGE; GRAFT RECIPIENT; GROWTH RATE; HORMONAL REGULATION; HORMONE BLOOD LEVEL; LONGEVITY; MORPHOGENESIS; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL; STROMA; TISSUE TRANSPLANTATION; WILD TYPE;

MUS;

EID: 37349047198     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2007.10.004     Document Type: Article

References (45)

1. Akashi M., and Koeffler H.P. Li-Fraumeni syndrome and the role of the p53 tumor suppressor gene in cancer susceptibility. Clin. Obstet. Gynecol. 41 (1998) 172-199
2. Becker K.A., Lu S., Dickinson E.S., Dunphy K.A., Mathews L., Schneider S.S., and Jerry D.J. Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-[beta]-dependent pathways. Oncogene 24 (2005) 6345-6353
3. Bendall S.C., Stewart M.H., Menendez P., George D., Vijayaragavan K., Werbowetski-Ogilvie T., Ramos-Mejia V., Rouleau A., Yang J., Bosse M., Lajoie G., and Bhatia M. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nat. Adv. Online Publ. (2007)
4. Bonnette S.G., and Hadsell D.L. Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds. Endocrinology 142 (2001) 4937-4945
5. Bourdon J.C., Fernandes K., Murray-Zmijewski F., Liu G., Diot A., Xirodimas D.P., Saville M.K., and Lane D.P. p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19 (2005) 2122-2137
6. Buckbinder L., Talbott R., Velasco-Miguel S., Takenaka I., Faha B., Seizinger B., and Kley N. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377 (1995) 646-649
7. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., and Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282 (1998) 1497-1501
8. Chao C., Saito S., Anderson C.W., Appella E., and Xu Y. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc. Natl. Acad Sci. U. S. A. 97 (2000) 11936-11941
9. Coles C., Condie A., Chetty U., Michael Steel C., John Evans H., and Prosser J. p53 mutations in breast cancer. Cancer Res. 52 (1992) 5291-5298
10. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A., Butel J.S., and Allan B. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992) 215-221
11. Dumble M., Moore L., Chambers S.M., Geiger H., Van Zant G., Goodell M.A., and Donehower L.A. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109 (2007) 1736-1742
12. Gatza C., Moore L., Dumble M., and Donehower L.A. Tumor suppressor dosage regulates stem cell dynamics during aging. Cell Cycle 6 (2007) 52-55
13. Hankinson S.E., Willett W.C., Colditz G.A., Hunter D.J., Michaud D.S., Deroo B., Rosner B., Speizer F.E., and Pollak M. Circulating concentrations of insulin-like growth factor I and risk of breast cancer. Lancet 351 (1998) 1393-1396
14. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P.C., Cervera P., and Le Bouc Y. IGF-1 receptor regulates life span and resistance to oxidative stress in mice. Nature 421 (2003) 182-187
15. Jacks T., Remington L., Williams B.O., Schmitt E.M., Halachmi S., Bronson R.T., and Weinberg R.A. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4 (1994) 1-7
16. Jerry D.J., Kuperwasser C., Downing S.R., Pinkas J., He C., Dickinson E., Marconi S., and Naber S.P. Delayed involution of the mammary epithelium in BALB/c-p53null mice. Oncogene 17 (1998) 2305-2312
17. Kuperwasser C., Pinkas J., Hurlbut G.D., Naber S.P., and Jerry D.J. Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment. Cancer Res 60 (2000) 2723-2729
18. Liao L., Dearth R.K., Zhou S., Britton O.L., Lee A.V., and Xu J. Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency. Endocrinology 147 (2006) 3877-3888
19. Liu J.L., and LeRoith D. Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Endocrinology 140 (1999) 5178-5184
20. Lozano G., and Elledge S.J. p53 sends nucleotides to repair DNA. Nature 404 (2000) 24-25
21. Maier B., Gluba W., Bernier B., Turner T., Mohammad K., Guise T., Sutherland A., Thorner M., and Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18 (2004) 306-319
22. Medina D., and Kittrell F.S. p53 function is required for hormone-mediated protection of mouse mammary tumorigenesis. Cancer Res. 63 (2003) 6140-6143
23. Medina D., Kittrell F.S., Shephard A., Stephens L.C., Jiang C., Allred D.C., McCarthy M., and Ullrich R.L. Biological and genetic properties of the p53 null preneoplastic mammary epithelium. FASEB J. 16 (2002) 881-883
24. Minter L.M., Dickinson E.S., Naber S.P., and Jerry D.J. Epithelial cell cycling predicts p53 responsiveness to {gamma}-irradiation during post-natal mammary gland development. Development 129 (2002) 2997-3008
25. Moll U.M., Riou G., and Levine A.J. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc. Natl. Acad Sci. U. S. A. 89 (1992) 7262-7266
26. Moore, L., Lu, X., Ghebranious, N., Tyner, S., Donehower, L.A., in press. Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity. Mech. Aging Dev.
27. Musaro A., Giacinti C., Borsellino G., Dobrowolny G., Pelosi L., Cairns L., Ottolenghi S., Cossu G., Bernardi G., Battistini L., Molinaro M., and Rosenthal N. Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. PNAS 101 (2004) 1206-1210
28. Niedernhofer L.J., Garinis G.A., Raams A., Lalai A.S., Robinson A.R., Appeldoorn E., Odijk H., Oostendorp R., Ahmad A., van Leeuwen W., Theil A.F., Vermeulen W., van der Horst G.T.J., Meinecke P., Kleijer W.J., Vijg J., Jaspers N.G.J., and Hoeijmakers J.H.J. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444 (2006) 1038-1043
29. Purdie C.A., Harrison D.J., Peter A., Dobbie L., White S., Howie S.E., Salter D.M., Bird C.C., Wyllie A.H., and Hooper M.L. Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 9 (1994) 603-609
30. Richards R.G., Klotz D.M., Walker M.P., and DiAugustine R.P. Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology 145 (2004) 3106-3110
31. Richert M.M., Schwertfeger K.L., Ryder J.W., and Anderson S.M. An atlas of mouse mammary gland development. J. Mammary Gland Biol. Neoplasia 5 (2000) 227-241
32. Ruan W., and Kleinberg D.L. Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology 140 (1999) 5075-5081
33. Ruan W., Monaco M.E., and Kleinberg D.L. Progesterone stimulates mammary gland ductal morphogenesis by synergizing with and enhancing insulin-like growth factor-I action. Endocrinology 146 (2005) 1170-1178
34. Shackleton M., Vaillant F., Simpson K.J., Stingl J., Smyth G.K., Asselin-Labat M.L., Wu L., Lindeman G.J., and Visvader J.E. Generation of a functional mammary gland from a single stem cell. Nature 439 (2006) 84-88
35. Shukla V., Coumoul X., Cao L., Wang R.H., Xiao C., Xu X., Ando S., Yakar S., LeRoith D., and Deng C. Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Res. 66 (2006) 7151-7157
36. Stambolic V., MacPherson D., Sas D., Lin Y., Snow B., Jang Y., Benchimol S., and Mak T.W. Regulation of PTEN Transcription by p53. Mol. Cell 8 (2001) 317-325
37. Sternlicht M.D., Kouros-Mehr H., Lu P., and Werb Z. Hormonal and local control of mammary branching morphogenesis. Differentiation 74 (2006) 365-381
38. Stingl J., Eirew P., Ricketson I., Shackleton M., Vaillant F., Choi D., Li H.I., and Eaves C.J. Purification and unique properties of mammary epithelial stem cells. Nature 439 (2006) 993-997
39. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X.B., Soron G., Cooper B., Brayton C., Park S.H., Thompson T., Karsenty G., Bradley A., and Donehower L.A. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
40. van der Pluijm I., Garinis G.A., Brandt R.M., Gorgels T.G., Wijnhoven S.W., Diderich K.E., deWit J., Mitchell J.R., vanOostrom C., Beems R., Niedernhofer L.J., Velasco S., Friedberg E.C., Tanaka K., van Steeg H., Hoeijmakers J.H., and van der Horst G.T. Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 5 (2006) e2
41. Vogelstein B., Lane D., and Levine A.J. Surfing the p53 network. Nature 408 (2000) 307-310
42. Walden P.D., Ruan W., Feldman M., and Kleinberg D.L. Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development. Endocrinology 139 (1998) 659-662
43. Werner H., Karnieli E., Rauscher III F.J., and LeRoith D. Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptorágene. PNAS 93 (1996) 8318-8323
44. Woodward W.A., Chen M.S., Behbod F., and Rosen J.M. On mammary stem cells. J. Cell Sci. 118 (2005) 3585-3594
45. Xu X., Qiao W., Linke S.P., Cao L., Li W.M., Furth P.A., Harris C.C., and Deng C.X. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat. Genet. 28 (2001) 266-271