Immunogenicity of Helicobacter pylori urease B protein and DNA vaccines in a mouse model

Journal of Pediatric Gastroenterology and Nutrition

Volumn 45, Issue 4, 2007, Pages 493-496

  Bégué, Rodolfo E ^a,b,c   Cruz, Alma R ^b   Ramgoolam, Andres ^a   Breslin, Mary B ^a,b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The Research Institute for Children at Children's Hospital New Orleans   (United States)

^c CHILDREN S HOSPITAL   (United States)

Author keywords

DNA vaccine; Helicobacter pylori; Prime boost approach

Indexed keywords

BACTERIUM ANTIBODY; DNA FOLLOWING PROTEIN; DNA PRECEDING PROTEIN; DNA VACCINE; FREUND ADJUVANT; HELICOBACTER PYLORI VACCINE; PROTEIN; UNCLASSIFIED DRUG; UREASE B PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNOGENICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL VACCINES; DISEASE MODELS, ANIMAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; UREASE; VACCINATION; VACCINES, DNA;

HELICOBACTER PYLORI; MUS;

EID: 37349024298     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e31806c7bf8     Document Type: Article

References (18)

1. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-86.
2. Eaton KA, Brooks CL, Morgan DR, et al. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 1991;59:2470-5.
3. Michetti P, Corthésy-Theulaz I, Davin C, et al. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology 1994;107:1002-11.
4. Ferrero RL, Thiberge JM, Huerre M, et al. Recombinant antigens prepared from the urease subunits of Helicobacter spp: evidence of protection in a mouse model of gastric infection. Infect Immun 1994;62:4981-9.
5. Zavala-Spinetti L, Breslin MB, Correa H, et al. Construction and evaluation of a Helicobacter pylori urease B DNA vaccine. Helicobacter 2006;11:517-22.
6. Anttila M, Eskola J, Åhman H, et al. Avidity of IgGfor Streptococcus pneumoniae type 6B and 23F polysaccharides in infants primed with pneumococcal conjugates and boosted with polysaccharide or conjugate vaccines. J Infect Dis 1998;177:1614-21.
7. Hirota K, Nagata K, Norose Y, et al. Identification of an antigenic epitope in Helicobacter pylori urease that induces neutralizing antibody production. Infect Immun 2001;69:6597-603.
8. Blanchard TG, Czinn SJ. Immunology of Helicobacter pylori and prospects for vaccine. Gastroenterol Clin N Am 2000;29:671-85.
9. Ermak TH, Giannasca PJ, Nichols R, et al. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHCclass II-restricted responses. J Exp Med 1998;188:2277-88.
10. Guy B, Hessler C, Fourage S, et al. Systemic immunization with urease protects mice against Helicobacter pylori infection. Vaccine 1998;16:850-6.
11. Lee CK, Weltzin R, Thomas WD Jr, et al. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J Infect Dis 1995;172:161-72.
12. Weltzin R, Guy B, Thomas WD, et al. Parenteral adjuvant activities of Escherichia coli heat-labile toxin and its B subunit for immunization of mice against gastric Helicobacter pylori infection. Infect Immun 2000;68:2775-82.
13. Hatzifoti C, Bajaj-Elliot M, Dorrell N, et al. A plasmid immunization construct encoding urease B of Helicobacter pylori induces an antigen-specific antibody response and upregulates the expression of beta-defensins and IL-10 in the stomach of immunized mice. Vaccine 2004;22:2651-9.
14. Dzwonek A, Mikula M, Woszczynski M, et al. Protective effect of vaccination with DNA of the H. pylori genomic library in experimentally infected mice. Cell Mol Biol Lett 2004;9:483-95.
15. Miyashita M, Joh T, Watanabe K, et al. Immune responses in mice to intranasal and intracutaneous administration of a DNA vaccine encoding Helicobacter pylori-catalase. Vaccine 2002;20:2336-42.
16. Todoriko I, Joh T, Watanabe K, et al. Suppressive effects of DNA vaccines encoding heat shock protein on Helicobacter pylori-induced gastritis in mice. Biochem Biophys Res Commun 2000;277:159-63.
17. Qiu JT, Chang TC, Lin CT. Novel codon-optimized GM-CSF gene as an adjuvant to enhance the immunity of a DNA vaccine against HIV-1 Gag. Vaccine 2007;25:253-63.
18. Li J, Ye ZX, Li KN, et al. HSP70 gene fused with Hantavirus S segment DNA significantly enhances the DNA vaccine potency against hantaviral nucleocapsid protein in vivo. Vaccine 2007;25:239-52.