An intermediary role of proHB-EGF sheadding in growth factor-induced c-Myc gene expression

Journal of Cellular Physiology

Volumn 214, Issue 2, 2008, Pages 465-473

  Nanba, Daisuke ^a,c   Inoue, Hirofumi ^a   Shigemi, Yuka ^a   Shirakata, Yuji ^a   Hashimoto, Koji ^a   Higashiyama, Shigeki ^a,b  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; METALLOPROTEINASE INHIBITOR; MUTANT PROTEIN;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; FIBROBLAST CULTURE; GENE EXPRESSION; GENE INDUCTION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

ADENOVIRIDAE; ALKALINE PHOSPHATASE; ANIMALS; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL LINE, TUMOR; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; EPIDERMAL GROWTH FACTOR; EPIGENESIS, GENETIC; FIBROBLAST GROWTH FACTOR 2; FIBROBLASTS; FIBROSARCOMA; GENE EXPRESSION; GENES, MYC; HEPARIN; HUMANS; KERATINOCYTES; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MUTATION; PROMOTER REGIONS (GENETICS); RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 37349014115     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21233     Document Type: Article

References (40)

1. Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, Ohmoto H, Node K. Yoshino K, Ishiguro H, Asanuma H, Sanada S, Matsumura Y, Takeda H, Beppu S, Tada M, Hori M, Higashiyama S. 2002. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy. Nat Med 8:35-40.
2. Barna M, Hawe N, Niswander L, Pandolfi PP. 2000. Plzf regulates limb and axial skeletal patterning. Nat Genet 25:166-172.
3. Barone MV, Courtneidge SA. 1995. Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature 378:509-512.
4. Blobel CP. 2005. ADAMs: Key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6:32-43.
5. Bouchard C, Thieke K, Maier A, Saffrich R, Hanley-Hyde J, Ansorge W, Reed S, Sicinski P, Bartek J, Eilers M. 1999. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J 18:5321-5333.
6. Cheung P, Tanner KG, Cheung WL, Sassone-Corsi P, Denu JM, Allis CD. 2000. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell 5:905-915.
7. Chiariello M, Marinissen MJ, Gutkind JS. 2001. Regulation of c-myc expression by PDGF through Rho GTPases. Nat Cell Biol 3:580-586.
8. Dang CV. 1999. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19:1-11.
9. Galaktionov K, Chen X, Beach D. 1996. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382:511-517.
10. Gechtman Z, Alonso JL, Raab G, Ingber DE, Klagsbrun M. 1999. The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading. J Biol Chem 274:28828-28835.
11. Goishi K, Higashiyama S, Klagsbrun M, Nakano N, Umata T, Ishikawa M, Mekada E, Taniguchi N. 1995. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: Conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell 6:967-980.
12. Hashimoto K, Higashiyama S, Asada H, Hashimura E, Kobayashi T, Sudo K, Nakagawa T, Damm D, Yoshikawa K, Taniguchi N. 1994. Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem 269:20060-20066.
13. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. 1998. Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512.
14. Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, Dang CV, Sedivy JM, Eick D, Vogelstein B, Kinzler KW. 2000. Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci USA 97:2229-2234.
15. Higashiyama S, Nanba D. 2005. ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta 1751:110-117.
16. Huntley S, Baggott DM, Hamilton AT, Tran-Gyamfi M, Yang S, Kim J, Gordon L, Branscomb E, Stubbs L. 2006. A comprehensive catalog of human KRAB-associated zinc finger genes: Insights into the evolutionary history of a large family of transcriptional repressors. Genome Res 16:669-677.
17. Iwamoto R, Yamazaki S, Asakura M, Takashima S, Hasuwa H, Miyado K, Adachi S, Kitakaze M, Hashimoto K, Raab G, Nanba D, Higashiyama S, Hori M, Klagsbrun M, Mekada E. 2003. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci USA 100:3221-3226.
18. Kanegae Y, Lee G, Sato Y, Tanaka M, Nakai M, Sakaki T, Sugano S, Saito I. 1995. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res 23:3816-3821.
19. Kerkhoff E, Houben R, Loffler S, Troppmair J, Lee JE, Rapp UR. 1998. Regulation of c-myc expression by Ras/Raf signalling. Oncogene 16:211-216.
20. Kinugasa Y, Hieda M, Hori M, Higashiyama S. 2007. The carboxyl-terminal fragment of Pro-HB-EGF reverses Bcl6-mediated gene repression. J Biol Chem 282:14797-14806.
21. Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. 1997. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387:422-426.
22. Mateyak MK, Obaya AJ, Adachi S, Sedivy JM. 1997. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 8:1039-1048.
23. McConnell MJ, Chevallier N, Berkofsky-Fessler W, Giltnane JM, Malani RB, Staudt LM, Licht JD. 2003. Growth suppression by acute promyelocyte leukemia-associated protein PLZF is mediated by repression of c-myc expression. Mol Cell Biol 23:9375-9388.
24. Miyagawa J, Higashiyama S, Kawata S, Inui Y, Tamura S, Yamamoto K, Nishida M, Nakamura T, Yamashita S, Matsuzawa Y, Taniguchi N. 1995. Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques. J Clin Invest 95:404-411.
25. Murphy MJ, Wilson A, Trumpp A. 2005. More than just proliferation: Myc function in stem cells. Trends Cell Biol 15:128-137.
26. Nanba D, Mammoto A, Hashimoto K, Higashiyama S. 2003. Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. J Cell Biol 163:489-502.
27. Niwa H, Yamamura K, Miyazaki J. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-199.
28. Numoto M, Niwa O, Kaplan J, Wong KK, Merrell K, Kamiya K, Yanagihara K, Calame K. 1993. Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins. Nucleic Acids Res 21:3767-3775.
29. Obaya AJ, Mateyak MK, Sedivy JM. 1999. Mysterious liaisons: The relationship between c-Myc and the cell cycle. Oncogene 18:2934-2941.
30. Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P. 2005. ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. EMBO J 24:742-752.
31. Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP. 2004. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164:769-779.
32. Shirakata Y, Kimura R, Nanba D, Iwamoto R, Tokumaru S, Morimoto C, Yokota K, Nakamura M, Sayama K, Mekada E, Higashiyama S, Hashimoto K. 2005. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. J Cell Sci 118:2363-2370.
33. Tachibana K, Takayama N, Matsuo K, Kato S, Yamamoto K, Ohyama K, Umezawa A, Takano T. 1993. Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc. Gene 124:231-237.
34. Takenobu H, Yamazaki A, Hirata M, Umata T, Mekada E. 2003. The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades. J Biol Chem 278:17255-17262.
35. Tokumaru S, Higashiyama S, Endo T, Nakagawa T, Miyagawa JI, Yamamori K, Hanakawa Y, Ohmoto H, Yoshino K, Shirakata Y, Matsuzawa Y, Hashimoto K, Taniguchi N. 2000. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J Cell Biol 151:209-220.
36. Umata T, Hirata M, Takahashi T, Ryu F, Shida S, Takahashi Y, Tsuneoka M, Miura Y, Masuda M, Horiguchi Y, Mekada E. 2001. A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. J Biol Chem 276:30475-30482.
37. Wang YN, Chen YJ, Chang WC. 2006. Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression. Mol Pharmacol 69:85-98.
38. Yeyati PL, Shaknovich R, Boterashvili S, Li J, Ball HJ, Waxman S, Nason-Burchenal K, Dmitrovsky E, Zelent A, Licht JD. 1999. Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene 18:925-934.
39. Yu BW, Ichinose I, Bonham MA, Zajac-Kaye M. 1993. Somatic mutations in c-myc intron 1 cluster in discrete domains that define protein binding sequences. J Biol Chem 268:19586-19592.
40. Zajac-Kaye M, Levens D. 1990. Phosphorylation-dependent binding of a 138-kDa myc intron factor to a regulatory element in the first intron of the c-myc gene. J Biol Chem 265:4547-4551.