Leptin stimulates parathyroid hormone related peptide expression in the endochondral growth plate

Journal of Pediatric Endocrinology and Metabolism

Volumn 20, Issue 11, 2007, Pages 1215-1222

  Gat Yablonski, G ^a,b   Shtaif, B ^a,b   Phillip, Moshe ^a,b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Growth plate; Ihh; Leptin; PTHrP

Indexed keywords

LEPTIN; PARATHYROID HORMONE RELATED PROTEIN; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; FEEDBACK SYSTEM; GROWTH PLATE; HORMONE ACTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VIVO STUDY; MALE; MANDIBLE CONDYLE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TISSUE CULTURE;

EID: 37349010660     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2007.20.11.1215     Document Type: Article

References (31)

1. Trayhurn P, Hoggard N, Mercer JG, Rayner DV. Leptin: fundamental aspects. Int J Obes 1999; 23: 22-28.
2. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68: 437-446.
3. Ryan AS, Elahi D. The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity and age in women. J Clin Endocrinol Metab 1996; 81: 4433-4438.
4. Wauters M, Considine RV, Van Gaal LF. Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 2000; 143:293-311.
5. Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science 1998; 281: 1683-1686.
6. Marikovsky M, Rosenblum CI, Faltin Z, Friedman-Einat M. Appearance of leptin in wound fluid as a response to injury. Wound Repair Regen 2002; 10: 302-307.
7. Campfield LA, Smith FJ, Burn P. Ob protein: a hormonal controller of central neural networks mediating behavioral, metabolic and neuroendocrine responses. Endocrinol Metab 1997; 4: 81-102.
8. Ahima RS, Saper CB, Flier JS, Elmquist JK. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 2000; 21: 263-307.
9. Tannenbaum GS, Gurd W, Lapointe M. Leptin is a potent stimulator of spontaneous pulsatile growth hormone secretion and the growth hormone response to growth hormone releasing hormone. Endocrinology 1998; 139: 3871-3875.
10. Pombo M, Pombo CM, Garcia A, Caminos E, Gualillo O, Alvarez CV, Casanueva FF, Dieguez C. Hormonal control of growth hormone secretion. Horm Res 2001; 55: 11-16.
11. Steppan CM, Crawford DT, Chidsey-Frink KL, Ke H, Swick AG. Leptin is a potent stimulator of bone growth in ob/ob mice. Regul Pept 2000; 92: 73-78.
12. Pasco JA, Henry MJ, Kotowicz MA, Collier GR, Ball MJ, Ugoni AM, Nicholson GC. Serum leptin levels are associated with bone mass in nonobese women. Clin Endocrinol Metab 2001; 86: 1884-1887.
13. Cornish J, Callon KE, Bava U, Lin C, Naot D, Hill BL, Grey AB, Broom N, Myers DE, Nicholson GC, Reid IR. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol 2002; 175: 405-415.
14. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G. Leptin inhibits bone formation through a hypothalamic relay; a central control of bone mass. Cell 2000; 100: 197-207.
15. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002; 111: 305-317.
16. Gat-Yablonski G, Ben-Ari T, Shtaif B, Potievsky O, Moran O, Eshet R, Maor G, Segev Y, Phillip M. Leptin reverses the inhibitory effect of caloric restriction on growth. Endocrinology 2004; 145: 343-350.
17. Maor G, Rochwerger M, Segev Y, Phillip M. Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. J Bone Miner Res 2002; 17: 1034-1043.
18. Juppner H. Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development. Pediatr Nephrol 2000; 14: 606-611.
19. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, Philbrick WM, Broadus AE, Baron R. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Clin Endocrinol Metab 2001; 86: 1884-1887.
20. Gertler A, Simmons J, Keisler DH. Large-scale preparation of biologically active recombinant ovine obese protein (leptin). FEBS Lett 1998; 422: 137-140.
21. Wilsman NJ, Farnum CE, Leiferman EM, Fry M, Barreto C. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. J Orthop Res 1996; 6: 927-936.
22. Tang GH, Rabie ABM, Hagg U. Indian hedgehog: a mechanotransduction mediator in condylar cartilage. J Dent Res 2004; 83: 434-438.
23. Suda N, Shibata S, Yamazaki K, Kuroda T, Senior PV, Beck F, Hammond VE. Parathyroid hormone-related protein regulates proliferation of condylar hypertrophic chondrocytes. J Bone Miner Res 1999; 14: 1838-1847.
24. van der Eerden BC, Karperien M, Gevers EF, Lowik CW, Wit JM. Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: evidence for a locally acting growth restraining feedback loop after birth. J Bone Miner Res 2000; 15: 1045-1055.
25. Schipani E, Kruse K, Juppner H. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 1995; 268: 98-100.
26. Jobert AS, Zhang P, Couvineau A, Bonaventure J, Roume J, Le Merrer M, Silve C. Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia, J Clin lnvest 1998; 102: 34-40.
27. St Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 1999; 13: 2027-2086.
28. Long F, Zhang XM, Karp S, Yang Y, McMahon AP. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 2001; 128: 5099-5108.
29. de Miguel F, Fiaschi-Taesch N, Lopez-Talavera JC, Takane KK, Massfelder T, Helwig JJ, Stewart AF. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology 2001; 142: 4096-4105.
30. Kishida Y, Hirao M, Tamai N, Nampei A, Fujimoto T, Nakase T, Shimizu N, Yoshikawa H, Myoui A. Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Bone 2005; 37: 607-622.
31. Kindblom JM, Nilsson O, Hurme T, Ohlsson C, Savendahl L. Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. J Endocrinol 2002; 174: RI-R6.