Synthesis and biological evaluation of 2-amino-3-(3′, 4′, 5′-trimethoxyphenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents

Medicinal Chemistry

Volumn 3, Issue 6, 2007, Pages 507-512

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Remusat, Vincent ^a   Carrion, Maria Dora ^a   Cara, Carlota Lopez ^a   Cruz Lopez, Olga ^a   Preti, Delia ^a   Fruttarolo, Francesca ^a   Tabrizi, Mojgan Aghazadeh ^a   Balzarini, Jan ^b   Hamel, Ernest ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c Developmental Therapeutics Program   (United States)

Author keywords

2 aminothiophene; Bioisoster; Combretastatin A 4; Microtubule

Indexed keywords

(3,4,5 TRIMETHOXYBENZENESULFONYL)ACETONITRILE; (3,4,5 TRIMETHOXYPHENYLSULFANYL)ACETONITRILE; 2 AMINO 3 (3',4',5' TRIMETHOXYPHENYLSULFONYL) 5 ARYLTHIOPHENE DERIVATIVE; 2 AMINO 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHENE; 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YLAMINE; 5 (4 FLUOROPHENYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YLAMINE; 5 (4 METHOXYPHENYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YLAMINE; 5 (4 TOLYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YLAMINE; 5 (4 TRIFLUOROMETHYLPHENYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YLAMINE; 5 PHENYL 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YLAMINE; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; N [3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YL]ACETAMIDE; N [5 (4 FLUOROPHENYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YL]ACETAMIDE; N [5 (4 METHOXYPHENYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YL]ACETAMIDE; N [5 (4 TOLYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YL]ACETAMIDE; N [5 (4 TRIFLUOROMETHYLPHENYL) 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YL]ACETAMIDE; N [5 BROMO 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YL]ACETAMIDE; N [5 PHENYL 3 (3,4,5 TRIMETHOXYBENZENESULFONYL)THIOPHEN 2 YL]ACETAMIDE; SULFONE DERIVATIVE; SULFONYL DERIVATIVE; THIOPHENE DERIVATIVE; TUBULIN MODULATOR; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BROMINATION; CANCER INHIBITION; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; DRUG DESIGN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THIOPHENES; TUBULIN MODULATORS;

EID: 37349000579     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607782360380     Document Type: Article

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