Effects of epidural administration of dexmedetomidine on the minimum alveolar concentration of isoflurane in dogs

American Journal of Veterinary Research

Volumn 68, Issue 12, 2007, Pages 1308-1318

  Campagnol, Daniela ^a   Teixeira Neto, Francisco J ^a   Giordano, Tatiana ^a   Ferreira, Tatiana H ^a   Monteiro, Eduardo R ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; DEXMEDETOMIDINE; ISOFLURANE; SODIUM CHLORIDE;

ANESTHESIA INDUCTION; ANESTHESIA LEVEL; ANIMAL EXPERIMENT; ARTICLE; BISPECTRAL INDEX; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; CORRELATION ANALYSIS; DOG; DOSE TIME EFFECT RELATION; ELECTROMYOGRAPHY; EPIDURAL ANESTHESIA; FEMALE; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NOCICEPTIVE STIMULATION; NONHUMAN;

ANALGESICS, NON-NARCOTIC; ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; ANIMALS; DEXMEDETOMIDINE; DOGS; FEMALE; INJECTIONS, EPIDURAL; ISOFLURANE; MALE; PULMONARY ALVEOLI;

CANIS FAMILIARIS;

EID: 37249089498     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.68.12.1308     Document Type: Article

References (47)

1. 2-adrenergic agonist, in halo thane-anesthetized dogs. Anesth Analg 1988;67:611-615.
2. Kuusela E, Raekallio M, Anttila M, et al. Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs. J Vet Pharmacol Ther 2000;23:15-20.
3. Bloor BC, Frankland M, Alper G, et al. Hemodynamic and sedative effects of dexmedetomidine in dog. J Pharmacol Exp Ther 1992;263:690-697.
4. Kuusela E, Raekallic, M, Vaisänen M, et al. Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol-isoflurane anesthesia. Am J Vet Res 2001;62:1073-1080.
5. Pascoe PJ, Raekallio M, Kuusela E, et al. Changes in the minimum alveolar concentration of isoflurane and some cardiopulmonary measurements during three continuous infusion rates of dexmedetomidine in dogs. Vet Anaesth Analg 2006;33:97-103.
6. Sullivan AF, Dashwood MR, Dickenson AH. Alpha 2-adrenoceptor modulation of nociception in rat spinal cord: location, effects and interaction with morphine. Eur J Pharmacol 1987;138:169-177.
7. Sullivan AF, Kalso EA, Mcquay HJ, et al. The nociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anesthetized rat. Eur J Pharmacol 1992;215:127-133.
8. 2 receptor agonist dexmedetomidine in dogs: antinociception and carbon dioxide response. Anesthesiology 1994; 80:1057-1072.
9. Eger EI II, Saidman LJ, Brandstater BM. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 1965;26:756-763.
10. Quasha AL, Eger EI II, Tinker JH. Determinations and applications of MAC. Anesthesiology 1980;53:315-334.
11. Steffey EP. Inhalation anesthetics. In: Thurmon JC, Tranquilli WJ, Benson GJ, eds. Lumb & Jones veterinary anesthesia. 2nd ed. Baltimore: The Williams & Wilkins Co, 1996;297-329.
12. Laster MJ, Liu J, Eger EI II, et al. Electrical stimulation as a substitute for the tail clamp in the determination of minimum alveolar concentration. Anesth Analg 1993;76:1310-1312.
13. Zbinden AM, Petersen-Felix S, Thomson DA, et al. Anesthetic depth using multiple noxious stimuli during isoflurane/oxygen anesthesia. II. Hemodynamic responses. Anesthesiology 1994;80:261-267.
14. March PA, Muir WW Bispectral analysis of the electroencephalogram: a review of its development and use in anesthesia. Vet Anaesth Analg 2005;32:241-255.
15. Stanski DR, Shafer SL. Measuring depth of anesthesia. In: Miller RD, ed. Miller's anesthesia. 6th ed. Philadelphia: Churchill Livingstone, 2005;1227-1264.
16. Bimar J, Bellville JW Arousal reactions during anesthesia in man. Anesthesiology 1977;47:449-454.
17. Murrell JC, Johnson CB, White KL, et al. Changes in the EEG during castration in horses and ponies anaesthetized with halothane. Vet Anaesth Analg 2003;30:138-146.
18. Otto KA, Mally P. Noxious stimulation during orthopaedic surgery results in EEG 'arousal' or 'paradoxical arousal' reaction in isoflurane-anaesthetised sheep. Res Vet Sci 2003;75:103-112.
19. Johnson CB, Wilson PR, Woodbury MR, et al. Comparison of analgesic techniques for antler removal in halothane-anaesthetized red deer ( Cervus elaphus): electroencephalographic responses. Vet Anaesth Analg 2005;32:61-71.
20. Johansen JW, Sebel PS. Development and clinical application of electroencephalographic bispectrum monitoring. Anesthesiology 2000;93:1336-1344.
21. Antognini JF, Wang XW Carstens E. Isoflurane anaesthetic depth in goats monitored using the bispectral index of the electroencephalogram. Vet Res Commun 2000;24:361-370.
22. March PA, Muir WW III. Use of the bispectral index as a monitor of anesthetic depth in cats anesthetized with isoflurane. Am J Vet Res 2003;64:1534-1541.
23. Campagnol D, Teixeira Neto FJ, Monteiro ER, et al. Use of bispectral index to monitor depth of anesthesia in isoflurane-anesthetized dogs. Am J Vet Res 2007;68:1300-1307.
24. Valverde A, Morey TE, Hernandez J, et al. Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbits. Am J Vet Res 2003;64:957-962.
25. Ewing KK, Mohammed HO, Scarlett JM, et al. Reduction of isoflurane anesthetic requirement by medetomidine and its restoration by atipamezole in dogs. Am J Vet Res 1993;54:294-299.
26. Messner M, Beese U, Romsto J, et al. The bispectral index declines during neuromuscular block in fully awake persons. Anesth Analg 2003;97:488-491.
27. Vivien B, Maria S, Ouattara A, et al. Overestimation of bispectral index in sedated intensive care unit patients revealed by administration of muscle relaxant. Anesthesiology 2003;99:9-17.
28. Liu N, Chazot T, Huybrechts I, et al. The influence of a muscle relaxant bolus on bispectral and Datex-Ohmeda entropy values during propofol-remifentanil induced loss of consciousness. Anesth Analg 2005;101:1713-1718.
29. BAR. Anesthesiology 1981;54:390-398.
30. Schmeling WT, Ganjoo P, Staunton M, et al. Pretreatment with dexmedetomidine: altered indices of anesthetic depth for halothane in the neuraxis of cats. Anesth Analg 1999;88:625-632.
31. March PA, Muir WW III. Minimum alveolar concentration measures of central nervous system activation in cats anesthetized with isoflurane. Am J Vet Res 2003;64:1528-1533.
32. Steffey EP, Howland D Jr. Isoflurane potency in the dog and cat. Am J Vet Res 1977;38:1833-1836.
33. Hellyer PW, Mama KR, Shafford HL, et al. Effects of diazepam and flumazenil on minimum alveolar concentrations for dogs anesthetized with isoflurane or a combination of isoflurane and fentanyl. Am J Vet Res 2001;62:555-560.
34. Soares JHN, Ascoli FO, Gremiao IDF, et al. Isoflurane sparing action of epidurally administered xylazine hydrochloride in anesthetized dogs. Am J Vet Res 2004;65:854-859.
35. Takano, M, Takano Y, Yaksh TL. Release of calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal polypeptide (VIP) from rat spinal cord: modulation by alpha-2 agonists. Peptides 1993;14:371-378.
36. Li X, Eisenach JC. Alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes. J Pharmacol Exp Ther 2001;299:939-944.
37. Miller RD, Way WL, Eger El II. The effects of alpha-methyldopa, reserpine, guanethidine, and iproniazid on minimum alveolar anesthetic requirement (MAC). Anesthesiology 1968;29:1153-1158.
38. Aghajanian GK, Vandermaeken CP. Alpha2-adrenoceptor mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo. Science 1982;215:1394-1396.
39. Segal IS, Vickery RG, Walton JK, et al. Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Anesthesiology 1988;69:818-823.
40. Dahaba AA, Mattweber M, Fuchs A, et al. The effect of different stages of neuromuscular block on the bispectral index and the bispectral index-XP under remifentanit/propofol anesthesia. Anesth Analg 2004;99:781-787.
41. Greif R, Greenwald S, Schweitzer E, et al. Muscle relaxation does not alter hypnotic level during propofol anesthesia. Anesth Analg 2002;94:604-608.
42. Greene SA, Benson GJ, Tranquilli WJ, et al. Relationship of canine bispectral index to multiples of sevoflurane minimal alveolar concentration, using patch or subdermal electrodes. Comp Med 2002;52:424-428.
43. Carrasco-Jiménez MS, Martín Cancho MF, Lima JR, et al. Relationships between a proprietary index, bispectral index, and hemodynamic variables as a means for evaluating depth of anesthesia in dogs anesthetized with sevoflurane. Am J Vet Res 2004; 65:1128-1135.
44. Hikasa Y, Takase K, Saito K, et al. Antagonism of the emetic action of xylazine by α-adrenoceptor blocking agents. Eur J Pharmacol 1986;130:229-235
45. Hikasa Y, Ogasawara S, Takase K. Alpha adrenoceptor subtypes involved in the emetic action in dogs. J Pharmacol Exp Ther 1992;261:746-754.
46. Duke T, Cox AM, Remedios AM, et al. The analgesic effects of administering fentanyl or medetomidine in the lumbosacral epidural space of cats. Vet Surg 1994;23:143-148.
47. Colby ED, McCarthy LE, Borison HL. Emetic action of xylazine on the chemoreceptor trigger zone for vomiting in cats. J Vet Pharmacol Ther 1981;4:93-96.