Designing chitosan-dextran sulfate nanoparticles using charge ratios

AAPS PharmSciTech

Volumn 8, Issue 4, 2007, Pages

  Chen, Yan ^a   Mohanraj, Vellore J ^a   Wang, Fang ^a   Benson, Heather A E ^a  

^a CURTIN UNIVERSITY   (Australia)

Author keywords

Charge ratio; Chitosan; Dextran sulfate; Nanoparticles; Protein delivery; Sustained release

Indexed keywords

BOVINE SERUM ALBUMIN; CHITOSAN; DEXTRAN SULFATE; NANOPARTICLE; RHODAMINE 6G; DRUG CARRIER; PROTEIN; RHODAMINE;

ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; IN VITRO STUDY; ION EXCHANGE; PARTICLE SIZE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCESS OPTIMIZATION; PROTEIN SECRETION; PROTEIN STABILITY; SURFACE PROPERTY; ZETA POTENTIAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG FORMULATION; METHODOLOGY; PHARMACEUTICS; SOLUBILITY; TIME;

CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DEXTRAN SULFATE; DRUG CARRIERS; DRUG COMPOUNDING; ION EXCHANGE; NANOPARTICLES; PARTICLE SIZE; PROTEINS; RHODAMINES; SERUM ALBUMIN, BOVINE; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 37249075464     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0804098     Document Type: Article

References (17)

1. Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release. 2004;100:5-28.
2. Illum L, Jabbal-Gill I, Hinchcliffe M, Fisher AN, Davis SS. Chitosan as a novel nasal delivery system for vaccines. Adv Drug Deliv Rev. 2001;51:81-96.
3. Tang ESK, Huang M, Lim LY. Ultrasonication. of chitosan and chitosan nanoparticles. Int J Pharm. 2003;265:103-114.
4. Sinha VR, Singla. AY, Wadhawan S, et al. Chitosan microspheres as a potential carrier for drugs. Int J Pharm. 2004;274:1-33.
5. Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci. 1997;63:125-132.
6. De S, Robinson D. Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres. J Control Release. 2003;89:101-112.
7. Fernandez-Urrusuno R, Calvo P, Renuman-Lopez C, Vila-Jato JL, Alonso MJ. Enhancement of nasal absorption of insulin using chitosan nanoparticles. Pharm Res. 1999;16:1576-1581.
8. Xu Y, Du Y. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int J Pharm. 2003; 1250:215-226.
9. Chen Y, Mohanraj V, Parkin J. Chitosan-dextran sulfate nanoparticles for delivery of an anti-angiogenesis peptide. Int J Pept Res Ther. 2003; 10:621-629.
10. Pan Y, Li Y-j, Zhao H-y, et al. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption and of insulin in vivo. Int J Pharm. 2002;249:139-147.
11. Wang F. Micro and Nanoparticles for Site-Specific Drug Delivery in the Skin [master's thesis]. [thesis]. Perth, Australia: School of Pharmacy, Curtin University of Technology; 2005.
12. Tiyaboonchai W, Woiszwillo J, Middaugh CR. Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles. Eur J Pharm Sci. 2003;19:191-202.
13. Tiyaboonchai W, Woiszwillo J, Sims RC, Middaugh CR. Insulin containing polyethylenimine-dextran sulfate nanoparticles. Int J Pharm. 2003;255:139-151.
14. Ma Z, Yeoh HH, Lim LY. Formulation pH modulates the interaction of insulin with chitosan nanoparticles. J Pharm Sci. 2002;91:1396-1404.
15. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
16. Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso W. Chitosan and chitosan/ ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res. 1997;14:1431-1436.
17. Peng J, Xing X, Wang K, Tan W, He X, Huang S. Influence of anions on the formation and properties of chitosan-DNA nanoparticles. J Nanosci Nanotechnol. 2005;5:713-717.